진핵생물 번역 개시 인자 4 감마 2(p97 , NAT1 , DAP-5 라고도 함)는 EIF4G2 [5] [6] 유전자 에 의해 인간에서 암호화되는 단백질 이다.
기능. 번역개시는 eIF4A, eIF4E 및 eIF4G의 3개의 서브유닛으로 이루어진 캡결합단백질복합체인 진핵생물번역개시인자 4F(eIF4F)에 의한 캡구조의 특이인식에 의해 매개된다. eIF4G2 유전자에 의해 코드된 단백질은 eIF4A 및 eIF3 에 대한 결합 부위를 포함하는 eIF4G1의 C 말단 영역과 유사성을 공유하며, eIF4G2는 N 말단에서 eIF4E에 대한 결합 부위를 추가로 포함한다. 캡의존적이고 독립적인 번역을 지원하는 eIF4G1과 달리 eIF4G2 유전자 생성물은 번역 불활성 복합체를 형성함으로써 번역의 일반적인 억제제로서 기능한다. 체외 및 체내 연구에 따르면 이 mRNA의 번역은 비 AUG(GUG) 코돈에서만 시작된다. 이 유전자의 다른 아이소폼을 코드하는 대체적으로 스플라이스된 전사 변이가 설명되었다.[7]
상호 작용 EIF4G2는 EIF3A 와 [8] [9] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000110321 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000005610 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yamanaka S, Poksay KS, Arnold KS, Innerarity TL (March 1997). "A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme" . Genes Dev . 11 (3): 321–33. doi :10.1101/gad.11.3.321 PMID 9030685 . ^ Levy-Strumpf N, Deiss LP, Berissi H, Kimchi A (March 1997). "DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death" . Mol. Cell. Biol . 17 (3): 1615–25. doi :10.1128/mcb.17.3.1615 . 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