EEF1D

EEF1D
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2MVM, 2MVN, 2N51
식별자
에일리어스	EEF1D, EF-1D, EF1D, FP1047, 진핵 번역 신장 인자 1 델타
외부 ID	OMIM : 130592 MGI : 1913906 HomoloGene : 23404 GenCard : EEF1D
유전자 위치(인간)
크르.	8번 염색체(인간)
끝.	143,599,541 bp
유전자 위치(마우스)
크르.	15번 염색체(쥐)
끝.	75,781,405 bp
RNA발현패턴
	상단 표시 위치:
	아킬레스건; ; 췌장체; ; 갑상선 우엽; ; 전립선; ; 자궁경관; ; 갑상선 좌엽; ; 안저; ; 위체; ; 복부 피부; ; 근막;
	상단 표시 위치:
	원시적 특징; ; 콘딜; ; 밧세루; ; 내경동맥; ; 소마이트; ; 대동맥 판막; ; 상행 대동맥; ; 외경동맥; ; 모낭; ; 심내막 쿠션;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; 열충격단백질결합; 번역인자활성, RNA결합; 신호 변환기 활성; 번역 신장 인자 활성; 단백질 결합; 카드헤린 결합;
셀룰러 컴포넌트	세포질; 소포체; 핵; 진핵생물번역연장인자1복합체; 섬유 중심; 세포;
생물학적 과정	전사조절, DNA템플릿화; 세포사 조절; 병진 신장; mRNA 전사; 전사, DNA 템플릿; 이온화 방사선에 대한 세포 반응; I-kappaB인산화효소/NF-kappaB신호의 양성조절; 신호 변환; 단백질생합성;
	출처:아미고 / QuickGO
맞춤법
	1936
	66656
	ENSG00000104529; ENSG00000273594
	ENSMUSG000055762
	P29692
	P57776
NM_001130053; NM_001130054; NM_001130055; NM_001130056; NM_001130057;
	NM_001195203; NM_001289950; NM_001960; NM_032378; NM_001317743; NM_001330646
NM_001285429; NM_001285430; NM_001285431; NM_001285432; NM_001285433;
	NM_001285434; NM_023240; NM_029663
NP_001123525; NP_001123527; NP_001123528; NP_001123529; NP_001182132;
	NP_00127679; NP_001304672; NP_001317575; NP_001951; NP_115754
NP_001272358; NP_001272359; NP_001272360; NP_001272361; NP_001272362;
	NP_001272363; NP_075729; NP_083939
	위키데이터
인간 보기/편집	마우스 표시/편집

신장인자 1-델타는 EEF1D ^[5]유전자에 의해 인체 내에서 부호화되는 단백질이다.

기능.

이 유전자는 리보솜에 아미노아실 tRNA를 효소적으로 전달하는 역할을 하는 신장인자-1 복합체의 서브유닛을 코드한다.이 서브유닛은 구아닌 뉴클레오티드 교환인자로 기능합니다.이 서브유닛은 HIV-1 Tat과 상호작용하기 때문에 HIV-1 mRNA가 아닌 숙주세포의 번역을 억제하는 것으로 알려졌다.이 유전자에 대해 몇 가지 대체적으로 스플라이스된 전사 변형이 발견되었지만, 두 변종만의 전체 길이 특성이 결정되었다.^[6]

상호 작용

EEF1D는 글리실-tRNA 합성효소,^[7] EEF1G^[8]^[9] 및 KTN1과 ^[10]상호작용하는 것으로 나타났으며, TMEM63A와 ^[11]상호작용할 것으로 예상된다.

레퍼런스

^ ^a ^b ^c ENSG00000273594 GRCh38: 앙상블 릴리즈 89: ENSG00000104529, ENSG00000273594: Ensembl, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000055762 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sanders J, Raggiaschi R, Morales J, Möller W (Jul 1993). "The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1174 (1): 87–90. doi:10.1016/0167-4781(93)90097-W. PMID 8334168.
^ "Entrez Gene: EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)".
^ Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
^ Ong LL, Er CP, Ho A, Aung MT, Yu H (Aug 2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". The Journal of Biological Chemistry. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547.
^ "String Database". Retrieved 16 May 2014.

추가 정보

Venema RC, Peters HI, Traugh JA (Jul 1991). "Phosphorylation of elongation factor 1 (EF-1) and valyl-tRNA synthetase by protein kinase C and stimulation of EF-1 activity". The Journal of Biological Chemistry. 266 (19): 12574–80. PMID 2061327.
van Damme HT, Amons R, Karssies R, Timmers CJ, Janssen GM, Möller W (Aug 1990). "Elongation factor 1 beta of artemia: localization of functional sites and homology to elongation factor 1 delta". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1050 (1–3): 241–7. doi:10.1016/0167-4781(90)90174-z. PMID 2207149.
Bec G, Kerjan P, Zha XD, Waller JP (Dec 1989). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry. 264 (35): 21131–7. PMID 2556394.
Wolfson AD, Orlovsky AF, Gladilin KL (Oct 1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters. 238 (2): 262–4. doi:10.1016/0014-5793(88)80492-7. PMID 3169261. S2CID 45934458.
Mulner-Lorillon O, Minella O, Cormier P, Capony JP, Cavadore JC, Morales J, Poulhe R, Bellé R (Aug 1994). "Elongation factor EF-1 delta, a new target for maturation-promoting factor in Xenopus oocytes". The Journal of Biological Chemistry. 269 (31): 20201–7. PMID 8051108.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bec G, Kerjan P, Waller JP (Jan 1994). "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation". The Journal of Biological Chemistry. 269 (3): 2086–92. PMID 8294461.
Sanders J, Brandsma M, Janssen GM, Dijk J, Möller W (May 1996). "Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum". Journal of Cell Science. 109 (5): 1113–7. PMID 8743958.
Chang YW, Traugh JA (Nov 1997). "Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation". The Journal of Biological Chemistry. 272 (45): 28252–7. doi:10.1074/jbc.272.45.28252. PMID 9353277.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sheu GT, Traugh JA (Dec 1997). "Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII". The Journal of Biological Chemistry. 272 (52): 33290–7. doi:10.1074/jbc.272.52.33290. PMID 9407120.
Xiao H, Neuveut C, Benkirane M, Jeang KT (Mar 1998). "Interaction of the second coding exon of Tat with human EF-1 delta delineates a mechanism for HIV-1-mediated shut-off of host mRNA translation". Biochemical and Biophysical Research Communications. 244 (2): 384–9. doi:10.1006/bbrc.1998.8274. PMID 9514931.
Kolettas E, Lymboura M, Khazaie K, Luqmani Y (1998). "Modulation of elongation factor-1 delta (EF-1 delta) expression by oncogenes in human epithelial cells". Anticancer Research. 18 (1A): 385–92. PMID 9568107.
Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
Chacko G, Ling Q, Hajjar KA (Jul 1998). "Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta". The Journal of Biological Chemistry. 273 (31): 19840–6. doi:10.1074/jbc.273.31.19840. PMID 9677419.
Sheu GT, Traugh JA (Jan 1999). "A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII". Molecular and Cellular Biochemistry. 191 (1–2): 181–6. doi:10.1023/A:1006802125856. PMID 10094407. S2CID 775166.
Furusawa T, Moribe H, Kondoh H, Higashi Y (Dec 1999). "Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1". Molecular and Cellular Biology. 19 (12): 8581–90. doi:10.1128/mcb.19.12.8581. PMC 84984. PMID 10567582.
Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
Lei YX, Chen JK, Wu ZL (2002). "Blocking the translation elongation factor-1 delta with its antisense mRNA results in a significant reversal of its oncogenic potential". Teratogenesis, Carcinogenesis, and Mutagenesis. 22 (5): 377–83. doi:10.1002/tcm.10034. PMID 12210501.

인간 염색체 8번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] ENSG00000273594 GRCh38: 앙상블 릴리즈 89: ENSG00000104529, ENSG00000273594: Ensembl, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000055762 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8334168-5] Sanders J, Raggiaschi R, Morales J, Möller W (Jul 1993). "The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1174 (1): 87–90. doi:10.1016/0167-4781(93)90097-W. PMID 8334168.

[entrez-6] "Entrez Gene: EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)".

[pmid11829477-7] Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.

[pmid16189514-8] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid16169070-9] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

[pmid12773547-10] Ong LL, Er CP, Ho A, Aung MT, Yu H (Aug 2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". The Journal of Biological Chemistry. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547.

[String-11] "String Database". Retrieved 16 May 2014.

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EEF1D

네임스페이스

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목차

기능.

상호 작용

레퍼런스

추가 정보