EIF2S3

EIF2S3
식별자
에일리어스	EIF2S3, EIF2, EIF2G, EIF2gamma, eIF-2gA, 진핵생물 번역 개시인자 2 서브유닛 감마, MRXSBRK, MEHMO
외부 ID	OMIM: 300161 MGI: 1349431 HomoloGene: 9088 GeneCard: EIF2S3
유전자 위치(인간)
크르.	X염색체(인간)
끝.	24,078,810 bp
유전자 위치(마우스)
크르.	X염색체(쥐)
끝.	93,256,468 bp
RNA발현패턴
	상단 표시 위치:
	생식 상피; ; 두정 흉막; ; 내장 흉막; ; 경골; ; 단구; ; 안검결막; ; 자궁내막; ; 림프절; ; 췌장체; ; 정강이뼈전근;
	상단 표시 위치:
	어금니; ; 상악 융기; ; 손; ; 발; ; 내측 신경절 융기; ; 아트리움; ; 복벽; ; 신장 소체; ; 노른자낭; ; 소마이트;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	뉴클레오티드 결합; GTP 바인딩; 번역인자활성, RNA결합; 단백질 결합; 번역 개시 인자 활성; GTPase 활성; 카드헤린 결합;
셀룰러 컴포넌트	세포질; 세포; 세포외 엑소좀; 핵; 진핵생물번역개시인자2복합체;
생물학적 과정	번역 개시; 막 통과 수송; 단백질생합성; 번역 개시 복합체 형성;
	출처:아미고 / QuickGO
맞춤법
	1968
	26905
	ENSG00000130741
	ENSMUSG000035150
	P41091
	Q9Z0N1
	NM_001415
	NM_012010
	NP_001406
	NP_036140
	위키데이터
인간 보기/편집	마우스 표시/편집

진핵생물번역개시인자2서브유닛3(eIF2))는 EIF2S3유전자에 ^[5]^[6]^[7]의해 인체 내에서 암호화되는 단백질이다.

기능.

진핵생물번역개시인자2(eIF2)는 GTP 및 이니시에이터 tRNA와 3원복합체를 형성하고 40S 리보솜 서브유닛에 결합함으로써 단백질 합성의 초기 단계에서 기능한다.eIF2는 알파(α), 베타(β), 감마(γ, 본 기사)의 3개의 서브유닛으로 구성되며, 이 유전자에 의해 인코딩된 단백질은 감마 ^[7]서브유닛을 나타낸다.

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eIF2

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000130741 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000035150 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gaspar NJ, Kinzy TG, Scherer BJ, Humbelin M, Hershey JW, Merrick WC (Mar 1994). "Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit". J Biol Chem. 269 (5): 3415–22. doi:10.1016/S0021-9258(17)41878-3. PMID 8106381.
^ Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM (Dec 1998). "Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution". Hum Mol Genet. 7 (11): 1725–37. doi:10.1093/hmg/7.11.1725. PMID 9736774.
^ ^a ^b "Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa".

추가 정보

Ray MK, Chakraborty A, Datta B, et al. (1993). "Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide". Biochemistry. 32 (19): 5151–9. doi:10.1021/bi00070a026. PMID 8098621.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Brand SR, Kobayashi R, Mathews MB (1997). "The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR". J. Biol. Chem. 272 (13): 8388–95. doi:10.1074/jbc.272.13.8388. PMID 9079663.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Cai R, Carpick B, Chun RF, et al. (2000). "HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms". Arch. Biochem. Biophys. 373 (2): 361–7. doi:10.1006/abbi.1999.1583. PMID 10620360.
Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R (2000). "Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2". Nucleic Acids Res. 28 (4): 1011–8. doi:10.1093/nar/28.4.1011. PMC 102579. PMID 10648795.
Kruger M, Beger C, Li QX, et al. (2000). "Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8566–71. doi:10.1073/pnas.97.15.8566. PMC 26988. PMID 10900014.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Filippova GN, Cheng MK, Moore JM, et al. (2005). "Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development". Dev. Cell. 8 (1): 31–42. doi:10.1016/j.devcel.2004.10.018. PMID 15669143.
Marques AC, Dupanloup I, Vinckenbosch N, et al. (2006). "Emergence of young human genes after a burst of retroposition in primates". PLOS Biol. 3 (11): e357. doi:10.1371/journal.pbio.0030357. PMC 1251493. PMID 16201836.
Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV (2006). "Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases". Biochem. Biophys. Res. Commun. 338 (4): 1766–72. doi:10.1016/j.bbrc.2005.10.150. PMID 16288713.
Mikami S, Masutani M, Sonenberg N, et al. (2006). "An efficient mammalian cell-free translation system supplemented with translation factors". Protein Expr. Purif. 46 (2): 348–57. doi:10.1016/j.pep.2005.09.021. PMID 16289705.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell. Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

인간 X 염색체 및/또는 그와 관련된 단백질의 유전자에 대한 이 기사는 스텁이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000130741 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000035150 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8106381-5] Gaspar NJ, Kinzy TG, Scherer BJ, Humbelin M, Hershey JW, Merrick WC (Mar 1994). "Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit". J Biol Chem. 269 (5): 3415–22. doi:10.1016/S0021-9258(17)41878-3. PMID 8106381.

[pmid9736774-6] Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM (Dec 1998). "Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution". Hum Mol Genet. 7 (11): 1725–37. doi:10.1093/hmg/7.11.1725. PMID 9736774.

[entrez-7] "Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa".

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[3]

[4]

[5]

[6]

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