EIF5A2

EIF5A2
식별자
에일리어스	EIF5A2, EIF-5A2, eIF5모두, 진핵생물 번역 개시 인자 5A2
외부 ID	OMIM : 605782 MGI : 1933735 HomoloGene : 1490 GenCard : EIF5A2
유전자 위치(인간)
크르.	3번 염색체(인간)
끝.	170,908,644 bp
유전자 위치(마우스)
크르.	3번 염색체(마우스)
끝.	28,852,995 bp
RNA발현패턴
	상단 표시 위치:
	내피 세포; ; 브로드만 23구역; ; 자궁내막간질세포; ; 랑게르한스 섬; ; 핀; ; 전전두피질; ; 중측두회; ; 우관상 동맥; ; 아킬레스건; ; 흉부 대동맥;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	리보솜 결합; 번역 신장 인자 활성; GO:0001948, GO:0016582 단백질 결합; RNA결합;
셀룰러 컴포넌트	세포질; 세포; 소포체막; 세포막내소기관; 막; 핵공; 소포체; 핵;
생물학적 과정	mRNA 트랜스포트; 단백질생합성; 병진 신장 양의 조절; 병진 신장; 폴리아민 항상성; 정자 형성; 세포군 증식의 양성 조절; 단백질 수송; 변환 프레임 시프트; 번역 종료의 정의 조절;
	출처:아미고 / QuickGO
맞춤법
	56648
	208691
	ENSG00000163577
	ENSMUSG000050192
	Q9GZV4
	Q8BGY2
	NM_020390
	NM_177586
	NP_065123
	NP_808254
	위키데이터
인간 보기/편집	마우스 표시/편집

진핵생물번역개시인자 5A-2는 EIF5A2 유전자에 ^[5]의해 인체 내에서 암호화되는 단백질이다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000163577 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000050192 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EIF5A2 eukaryotic translation initiation factor 5A2".

추가 정보

Jenkins ZA, Hååg PG, Johansson HE (2001). "Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression". Genomics. 71 (1): 101–9. doi:10.1006/geno.2000.6418. PMID 11161802.
Guan XY, Sham JS, Tang TC, et al. (2001). "Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer". Cancer Research. 61 (9): 3806–9. PMID 11325856.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clement PM, Henderson CA, Jenkins ZA, Smit-McBride Z, Wolff EC, Hershey JW, Park MH, Johansson HE (2003). "Identification and characterization of eukaryotic initiation factor 5A-2". European Journal of Biochemistry. 270 (21): 4254–63. doi:10.1046/j.1432-1033.2003.03806.x. PMID 14622290.
Guan XY, Fung JM, Ma NF, et al. (2004). "Oncogenic role of eIF-5A2 in the development of ovarian cancer". Cancer Res. 64 (12): 4197–200. doi:10.1158/0008-5472.CAN-03-3747. PMID 15205331.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Christensen GL, Ivanov IP, Atkins JF, et al. (2005). "Screening the SPO11 and EIF5A2 genes in a population of infertile men". Fertility and Sterility. 84 (3): 758–60. doi:10.1016/j.fertnstert.2005.03.053. PMID 16169419.
Clement PM, Johansson HE, Wolff EC, Park MH (2006). "Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells". The FEBS Journal. 273 (6): 1102–14. doi:10.1111/j.1742-4658.2006.05135.x. PMC 4406228. PMID 16519677.
Xie D, Ma NF, Pan ZZ, Wu HX, Liu YD, Wu GQ, Kung HF, Guan XY (2008). "Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma". Human Pathology. 39 (1): 80–6. doi:10.1016/j.humpath.2007.05.011. PMID 17949776.
Yang GF, Xie D, Liu JH, Luo JH, Li LJ, Hua WF, Wu HM, Kung HF, Zeng YX, Guan XY (2009). "Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma". Gynecol. Oncol. 112 (2): 314–8. doi:10.1016/j.ygyno.2008.10.024. PMID 19054548.
Chen W, Luo JH, Hua WF, Zhou FJ, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D (2009). "Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy". Cancer Epidemiology, Biomarkers & Prevention. 18 (2): 400–8. doi:10.1158/1055-9965.EPI-08-0754. PMID 19155439.
Luo JH, Hua WF, Rao HL, Liao YJ, Kung HF, Zeng YX, Guan XY, Chen W, Xie D (2009). "Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder". Cancer Science. 100 (5): 896–902. doi:10.1111/j.1349-7006.2009.01126.x. PMID 19298601. S2CID 23225065.
Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY (2010). "Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma". Hepatology. 51 (4): 1255–63. doi:10.1002/hep.23451. PMID 20112425. S2CID 5328378.
Chen M, Huang JD, Deng HK, Dong S, Deng W, Tsang SL, Huen MS, Chen L, Zan T, Zhu GX, Guan XY (2011). "Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability". BMC Cancer. 11: 199. doi:10.1186/1471-2407-11-199. PMC 3118894. PMID 21612665.
He LR, Zhao HY, Li BK, Liu YH, Liu MZ, Guan XY, Bian XW, Zeng YX, Xie D (2011). "Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients". International Journal of Cancer. 129 (1): 143–50. doi:10.1002/ijc.25669. PMID 20830705. S2CID 205942112.

인간 염색체 3번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000163577 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000050192 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EIF5A2 eukaryotic translation initiation factor 5A2".

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