60S 리보솜 단백질 L11
60S ribosomal protein L11
60S 리보솜 단백질 L11은 인간에서 RPL11 유전자에 의해 암호화된 단백질이다.[5][6][7]
함수
리보솜은 단백질 합성을 촉진하는 세포기관으로 작은 40S 서브유닛과 큰 60S 서브유닛으로 구성된다. 이들 서브유닛은 모두 4종의 RNA종과 약 80종의 구조적으로 구별되는 단백질로 구성되어 있다. 이 유전자는 60S 서브유닛의 성분인 리보솜 단백질을 인코딩한다. 이 단백질은 L5P 리보솜 단백질군에 속한다. 그것은 세포질에 위치해 있다. 그 단백질은 아마도 5S rRNA와 관련이 있을 것이다. 다른 ISO 양식을 인코딩하는 대체 이음매 변형이 존재할 수 있지만, 그것들은 완전히 특징지어지지는 않았다. 리보솜 단백질을 인코딩하는 유전자의 전형적으로, 게놈을 통해 분산된 여러 개의 처리된 유사 유전자가 있다.[7]
상호작용
RPL11은 다음과 상호 작용하는 것으로 나타났다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000142676 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000059291 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ Graphodatsky AS, Vorobieva NV, Filipenko ML, Voronina EV, Frengen E, Prydz H (Jun 1999). "Assignment of the L11 ribosomal protein gene (RPL11) to human chromosome 1p36.1→p35 by in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 97–98. doi:10.1159/000015228. PMID 10343117. S2CID 26672114.
- ^ a b "Entrez Gene: RPL11 ribosomal protein L11".
{{cite web}}: 누락 또는 비어 있음url=(도움말) - ^ Koldamova RP, Lefterov IM, DiSabella MT, Almonte C, Watkins SC, Lazo JS (Jun 1999). "Human bleomycin hydrolase binds ribosomal proteins". Biochemistry. 38 (22): 7111–7. doi:10.1021/bi990135l. PMID 10353821.
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- ^ Dai MS, Sun XX, Lu H (Jul 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2". Mol. Cell. Biol. 28 (13): 4365–76. doi:10.1128/MCB.01662-07. PMC 2447154. PMID 18426907.
- ^ Uchi R, Kogo R, Kawahara K, Sudo T, Yokobori T, Eguchi H, et al. (October 2013). "PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression". British Journal of Cancer. 109 (8): 2199–206. doi:10.1038/bjc.2013.561. PMC 3798961. PMID 24045667.
- ^ Bernardi R, Scaglioni PP, Bergmann S, Horn HF, Vousden KH, Pandolfi PP (Jul 2004). "PML regulates p53 stability by sequestering Mdm2 to the nucleolus". Nat. Cell Biol. 6 (7): 665–72. doi:10.1038/ncb1147. PMID 15195100. S2CID 26281860.
추가 읽기
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