진핵생물번역개시인자2A (eIF2A )는 [5] [6] [7] EIF2A 유전자에 의해 인체 내에서 암호화되는 단백질 이다.eIF2A 단백질은 헤테로 이성질 eIF2 복합체의 하위 단위인 eIF2α 와 혼동해서는 안 됩니다. 대신, eIF2A는 진핵생물 번역 에서 별도의 메커니즘에 의해 기능한다.
기능. eIF2A는 푸로마이신 감수성 80S 사전 개시 복합체의 형성을 촉매하는 65kDa 단백질이다(Zoll et al., 2002). [OMIM [7] HCV IRES 에 의해 매개되는 번역 개시에 중요할 수 있지만, [8] [9]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000144895 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000027810 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC (Oct 2002). "Characterization of mammalian eIF2A and identification of the yeast homolog" . The Journal of Biological Chemistry . 277 (40): 37079–87. doi :10.1074/jbc.M207109200 PMID 12133843 . ^ Merrick WC (Jun 1992). "Mechanism and regulation of eukaryotic protein synthesis" . Microbiological Reviews . 56 (2): 291–315. doi :10.1128/MMBR.56.2.291-315.1992 . PMC 372869 PMID 1620067 . ^ a b "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A" .^ Kim JH, Park SM, Park JH, Keum SJ, Jang SK (Jun 2011). "eIF2A mediates translation of hepatitis C viral mRNA under stress conditions" . The EMBO Journal . 30 (12): 2454–64. doi :10.1038/emboj.2011.146 . PMC 3116280 PMID 21556050 . ^ Jaafar ZA, Oguro A, Nakamura Y, Kieft JS (December 2016). "Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling" . eLife . 5 : e21198. doi :10.7554/elife.21198 . PMC 5238962 PMID 28009256 .
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