진핵생물번역개시인자3 서브유닛D (eIF3d)는 [5] [6] EIF3D 유전자에 의해 인체 내에서 암호화되는 단백질 이다.
기능. eIF 중 가장 큰 진핵생물 번역 개시 인자 3(eIF3)은 적어도 10개의 동일하지 않은 서브유닛으로 이루어진 다단백질 복합체이다.복합체는 40S 리보솜 에 결합하고 40S 및 60S 리보솜 서브유닛을 해리 상태로 유지하도록 돕는다. 또한 eIF2/GTP/메티오닐-tRNA의 삼원복합체 와 상호작용하여 mRNA 결합을 촉진함으로써 40S 개시복합체 형성에 관여하는 것으로 생각된다. 이 유전자에 의해 암호화된 단백질은 eIF3 [6]
상호 작용 EIF3D는 PLDA1 [7] [8] [9] [10] EIF3A 와 상호작용하는 것으로 나타났다 .
EIF3D는 또한 비표준 메커니즘을 통해 c-Jun mRNA와 상호작용하는 것으로 나타났다. EIF4G 단백질이 번역을 매개하는 캡결합단백질로서 작용하는 대신 EIF3D는 EIF4G의 5' UTR 억제결합에서 구조를 가지며 EIF3D의 [11] 캡 결합 단백질로서의 EIF3D는 포도당 결핍과 같은 세포 스트레스 하에서 유전자 발현을 조절하는 데 중요한 것으로 여겨져 왔다. 포도당 결핍 조건 하 에서 c-Jun의 번역에서는 EIF3D의 캡 결합 활성이 10배 [12] [13]
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