EIF4G3

EIF4G3
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1HU3
식별자
에일리어스	EIF4G3, eIF-4G3, eIF4G3, eIF4GII, 진핵생물 번역 개시인자 4 감마3
외부 ID	OMIM : 603929 MGI : 1923935 HomoloGene : 2789 Gene Card : EIF4G3
유전자 위치(인간)
크르.	1번 염색체(인간)
끝.	21,185,285 bp
유전자 위치(마우스)
크르.	4번 염색체(쥐)
끝.	138,134,508 bp
RNA발현패턴
	상단 표시 위치:
	정자; ; 전두극; ; 브로드만 10구역; ; 중전두회; ; 자궁내막간질세포; ; 후중심회; ; 신경절 융기; ; 브로드만 23구역; ; 상전두회; ; 장피질;
	상단 표시 위치:
	정관; ; 무릎 관절; ; 소뇌 피질; ; 상전두회; ; 상완 삼두근; ; 측두근; ; 이복근; ; 전전두피질; ; 흉골윤활근; ; 수채관;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	RNA캡결합; 번역인자활성, RNA결합; 번역 개시 인자 활성; RNA결합; 단백질 결합; mRNA 결합;
셀룰러 컴포넌트	세포; 진핵생물번역개시인자4F복합체;
생물학적 과정	번역 개시; 바이러스 과정; 단백질생합성; 번역 규제; 번역 개시 조절; 자동 파지의 음성 조절;
	출처:아미고 / QuickGO
맞춤법
	8672
	230861
	ENSG000075151
	ENSMUSG000028760
	O43432
	Q80XI3
NM_001198801; NM_001198802; NM_001198803; NM_003760; NM_001391892;
	NM_001391893; NM_001391894; NM_001391895; NM_001391896; NM_001391897; NM_001391898; NM_001391899; NM_001391900; NM_001391901; NM_001391902; NM_001391903; NM_001391904; NM_001391905; NM_001391906; NM_001391907
	NM_001256195; NM_001256198; NM_172703; NM_001355699; NM_001355700
	NP_001185730; NP_001185731; NP_001185732; NP_003751
NP_001243124; NP_001243127; NP_766291; NP_001342628; NP_001342629;
	NP_001356059; NP_001356060
	위키데이터
인간 보기/편집	마우스 표시/편집

진핵생물 번역개시인자 4 감마3은 EIF4G3 ^[5]^[6]유전자에 의해 인체 내에서 암호화되는 단백질이다.이 유전자는 리보솜을 메신저 RNA ^[7]템플릿에 조립하는 것을 도와 번역 기능을 하는 단백질을 암호화한다.헷갈리게, 이 단백질은 보통 eIF4라고 불린다.GII는 EIF4G3가 진핵생물 번역 개시인자 4 감마와 유사한 세 번째 유전자이지만, 두 번째 아이소폼 EIF4G2는 활성 번역 개시 ^[8]인자가 아니다.

상호 작용

EIF4G3는 PABPC1과 ^[9]대화하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000075151 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000028760 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (Jan 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
^ "Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3".
^ Gingras AC, Raught B, Sonenberg N (1999). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation". Annu. Rev. Biochem. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469.
^ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
^ Imataka H, Gradi A, Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202.

추가 정보

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Imataka H, Gradi A, Sonenberg N (1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202.
Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N (1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMC 1171121. PMID 9878069.
Waskiewicz AJ, Johnson JC, Penn B, Mahalingam M, Kimball SR, Cooper JA (1999). "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo". Mol. Cell. Biol. 19 (3): 1871–80. doi:10.1128/MCB.19.3.1871. PMC 83980. PMID 10022874.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK (2001). "A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery". Mol. Cell. 7 (1): 193–203. doi:10.1016/S1097-2765(01)00167-8. PMID 11172724.
Gradi A, Svitkin YV, Sommergruber W, Imataka H, Morino S, Skern T, Sonenberg N (2003). "Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different". J. Virol. 77 (8): 5026–9. doi:10.1128/JVI.77.8.5026-5029.2003. PMC 152112. PMID 12663812.
Miura T, Shiratori Y, Shimma N (2003). "Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII". J. Biomol. NMR. 27 (3): 279–80. doi:10.1023/A:1025442322316. PMID 12975586. S2CID 46050990.
Qin H, Raught B, Sonenberg N, Goldstein EG, Edelman AM (2003). "Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I". J. Biol. Chem. 278 (49): 48570–9. doi:10.1074/jbc.M308781200. PMID 14507913.
Gradi A, Foeger N, Strong R, Svitkin YV, Sonenberg N, Skern T, Belsham GJ (2004). "Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro". J. Virol. 78 (7): 3271–8. doi:10.1128/JVI.78.7.3271-3278.2004. PMC 371048. PMID 15016848.
Lejeune F, Ranganathan AC, Maquat LE (2004). "eIF4G is required for the pioneer round of translation in mammalian cells". Nat. Struct. Mol. Biol. 11 (10): 992–1000. doi:10.1038/nsmb824. PMID 15361857. S2CID 3093989.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

인간 염색체 1번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000075151 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000028760 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9418880-5] Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (Jan 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.

[entrez-6] "Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3".

[7] Gingras AC, Raught B, Sonenberg N (1999). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation". Annu. Rev. Biochem. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469.

[8] Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.

[pmid9857202-9] Imataka H, Gradi A, Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202.

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EIF4G3

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레퍼런스

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