EIF2B5

EIF2B5
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	3 JUI
식별자
에일리어스	EIF2B5, CAH, CLE, EIF-2B, EIF2Bpsilon, LVWM, 진핵 번역 개시 인자 2B 서브유닛 엡실론
외부 ID	OMIM : 603945 MGI : 2446176 HomoloGene : 2903 GenCard : EIF2B5
유전자 위치(인간)
크르.	3번 염색체(인간)
끝.	184,194,196 bp
유전자 위치(마우스)
크르.	16번 염색체(쥐)
끝.	20,328,073 bp
RNA발현패턴
	상단 표시 위치:
	상부 신경; ; 위근; ; 뇌하수체 전엽; ; 중측두회; ; 소침샘; ; 갑상선 우엽; ; 복부 피부; ; 위체; ; 갑상선 좌엽; ; 직장;
	상단 표시 위치:
	정자 세포; ; 모룰라; ; 눈물샘; ; 정자질; ; 심내막 쿠션; ; 발목 관절; ; 입술; ; 소마이트; ; 노른자낭; ; 식도;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	번역 개시 인자 활성; 구아닐-플루오르화물교환인자활성; 단백질 결합; 번역 개시 인자 결합;
셀룰러 컴포넌트	세포질; 진핵생물번역개시인자2B복합체; 핵; 세포;
생물학적 과정	성상 세포 발달; 에이징; 펩타이드 호르몬에 대한 반응; 열에 대한 반응; 포도당에 대한 반응; 소포체 응력에 대한 반응; 성상세포분화; 난포 발달; 미엘리네이션; 올리고덴드로사이트발달; 번역 개시의 적극적인 조절; 해마의 발달; 번역 개시; 리튬 이온에 대한 반응; 단백질생합성; 아포토시스 과정의 양성 조절; 번역의 적극적인 규제; T세포수용체신호경로;
	출처:아미고 / QuickGO
맞춤법
	8893
	224045
	ENSG00000145191
	ENSMUSG00000003235
	문제 13144
	Q8CHW4
	NM_003907
	NM_172265
	NP_003898
	NP_758469
	위키데이터
인간 보기/편집	마우스 표시/편집

번역개시인자 eIF-2B 서브유닛 엡실론은 EIF2B5 ^[5]^[6]유전자에 의해 인체 내에서 암호화되는 단백질이다.

상호 작용

EIF2B5는 EIF2B2^[7] 및 EIF2B1과 ^[7]^[8]상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000145191 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000003235 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Asuru AI, Mellor H, Thomas NS, Yu L, Chen JJ, Crosby JS, Hartson SD, Kimball SR, Jefferson LS, Matts RL (Jul 1996). "Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human". Biochimica et Biophysica Acta. 1307 (3): 309–17. doi:10.1016/0167-4781(96)00054-1. PMID 8688466.
^ "Entrez Gene: EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa".
^ ^a ^b Anthony TG, Fabian JR, Kimball SR, Jefferson LS (Jun 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochimica et Biophysica Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

추가 정보

Leegwater PA, Pronk JC, van der Knaap MS (Sep 2003). "Leukoencephalopathy with vanishing white matter: from magnetic resonance imaging pattern to five genes". Journal of Child Neurology. 18 (9): 639–45. doi:10.1177/08830738030180091101. PMID 14572143. S2CID 22639954.
Chaudhri MA, Crawford AC (1991). "Carbon determination in human teeth by activation with He-3 ions". Biological Trace Element Research. 26–27: 521–7. doi:10.1007/BF02992708. PMID 1704758. S2CID 32236889.
Welsh GI, Miyamoto S, Price NT, Safer B, Proud CG (May 1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". The Journal of Biological Chemistry. 271 (19): 11410–3. doi:10.1074/jbc.271.19.11410. PMID 8626696.
Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (Jan 1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B". The Journal of Biological Chemistry. 273 (5): 3039–44. doi:10.1074/jbc.273.5.3039. PMID 9446619.
Welsh GI, Miller CM, Loughlin AJ, Price NT, Proud CG (Jan 1998). "Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin". FEBS Letters. 421 (2): 125–30. doi:10.1016/S0014-5793(97)01548-2. PMID 9468292. S2CID 29189093.
Leegwater PA, Könst AA, Kuyt B, Sandkuijl LA, Naidu S, Oudejans CB, Schutgens RB, Pronk JC, van der Knaap MS (Sep 1999). "The gene for leukoencephalopathy with vanishing white matter is located on chromosome 3q27". American Journal of Human Genetics. 65 (3): 728–34. doi:10.1086/302548. PMC 1377979. PMID 10441579.
Gomez E, Pavitt GD (Jun 2000). "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation". Molecular and Cellular Biology. 20 (11): 3965–76. doi:10.1128/MCB.20.11.3965-3976.2000. PMC 85753. PMID 10805739.
Anthony TG, Fabian JR, Kimball SR, Jefferson LS (Jun 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochimica et Biophysica Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.
Williams DD, Price NT, Loughlin AJ, Proud CG (Jul 2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein". The Journal of Biological Chemistry. 276 (27): 24697–703. doi:10.1074/jbc.M011788200. PMID 11323413.
Wang X, Paulin FE, Campbell LE, Gomez E, O'Brien K, Morrice N, Proud CG (Aug 2001). "Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo". The EMBO Journal. 20 (16): 4349–59. doi:10.1093/emboj/20.16.4349. PMC 125262. PMID 11500362.
Leegwater PA, Vermeulen G, Könst AA, Naidu S, Mulders J, Visser A, Kersbergen P, Mobach D, Fonds D, van Berkel CG, Lemmers RJ, Frants RR, Oudejans CB, Schutgens RB, Pronk JC, van der Knaap MS (Dec 2001). "Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter". Nature Genetics. 29 (4): 383–8. doi:10.1038/ng764. PMID 11704758. S2CID 20313523.
Wang X, Janmaat M, Beugnet A, Paulin FE, Proud CG (Oct 2002). "Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin". The Biochemical Journal. 367 (Pt 2): 475–81. doi:10.1042/BJ20020677. PMC 1222905. PMID 12133000.
Fogli A, Wong K, Eymard-Pierre E, Wenger J, Bouffard JP, Goldin E, Black DN, Boespflug-Tanguy O, Schiffmann R (Oct 2002). "Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus". Annals of Neurology. 52 (4): 506–10. doi:10.1002/ana.10339. PMID 12325082. S2CID 35748869.
Fogli A, Dionisi-Vici C, Deodato F, Bartuli A, Boespflug-Tanguy O, Bertini E (Dec 2002). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation". Neurology. 59 (12): 1966–8. doi:10.1212/01.wnl.0000041666.76863.47. PMID 12499492. S2CID 13129517.
Fogli A, Rodriguez D, Eymard-Pierre E, Bouhour F, Labauge P, Meaney BF, Zeesman S, Kaneski CR, Schiffmann R, Boespflug-Tanguy O (Jun 2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations". American Journal of Human Genetics. 72 (6): 1544–50. doi:10.1086/375404. PMC 1180314. PMID 12707859.
van der Knaap MS, van Berkel CG, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemsen MA, Plecko B, Hoffmann GF, Proud CG, Scheper GC, Pronk JC (Nov 2003). "eIF2B-related disorders: antenatal onset and involvement of multiple organs". American Journal of Human Genetics. 73 (5): 1199–207. doi:10.1086/379524. PMC 1180499. PMID 14566705.

인간 염색체 3번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000145191 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000003235 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8688466-5] Asuru AI, Mellor H, Thomas NS, Yu L, Chen JJ, Crosby JS, Hartson SD, Kimball SR, Jefferson LS, Matts RL (Jul 1996). "Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human". Biochimica et Biophysica Acta. 1307 (3): 309–17. doi:10.1016/0167-4781(96)00054-1. PMID 8688466.

[entrez-6] "Entrez Gene: EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa".

[pmid10858531-7] Anthony TG, Fabian JR, Kimball SR, Jefferson LS (Jun 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochimica et Biophysica Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.

[pmid17353931-8] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

Search

EIF2B5

네임스페이스

더

상호 작용

레퍼런스

추가 정보