수용체형 티로신-단백질 포스파타아제 엡실론 은 사람에게서 PTPRE [5] [6] 유전자 에 의해 암호화되는 효소 이다.
기능. 이 유전자에 의해 암호화된 단백질은 단백질 티로신 포스파타아제(PTP) 계열의 구성원이다. PTP는 세포 성장, 분화, 유사분열 주기, 그리고 발암성 변형을 포함한 다양한 세포 과정을 조절하는 신호 분자로 알려져 있다. 이 유전자의 두 가지 대체 스플라이스된 전사 변이체가 보고되었으며, 그 중 하나는 짧은 세포외 도메인, 단일 막간 영역 및 두 개의 탠덤 세포질 내 촉매 도메인을 갖는 수용체형 PTP를 코드하고, 다른 하나는 별개의 친수성 N-말단을 포함하고, 따라서 비-re를 나타내는 PTP를 코드한다. 이 PTP의 셉터 타입의 isoform. 생쥐에서 유사한 유전자에 대한 연구는 RAS 관련 신호 전달 경로, 사이토카인 유도 SATA 신호 전달 및 전압 게이트 K+ [6] 채널의 활성화에서 이 PTP의 조절 역할을 제안했다.
상호 작용 PTPRE는 KCNB1 과 [7] 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000132334 - 앙상블 , 2017년 5월 ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000041836 - 앙상블 , 2017년 5월 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ van den Maagdenberg AM, van den Hurk HH, Weghuis D, Wieringa B, Geurts van Kessel A, Hendriks WJ (April 1996). "Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization". Genomics . 30 (1): 128–9. doi :10.1006/geno.1995.0026 . PMID 8595895 . ^ a b "Entrez Gene: PTPRE protein tyrosine phosphatase, receptor type, E" . ^ Peretz A, Gil-Henn H, Sobko A, Shinder V, Attali B, Elson A (August 2000). "Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon" . EMBO J . 19 (15): 4036–45. doi :10.1093/emboj/19.15.4036 . PMC 306594 . PMID 10921884 .
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