PTPRO
PTPRO| PTPRO | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 에일리어스 | PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, 단백질 티로신 포스파타아제, 수용체 O형, 단백질 티로신 포스파타아제 수용체 O형 | ||||||||||||||||||||||||
| 외부 ID | OMIM : 600579 MGI : 1097152 HomoloGene : 21564 GenCard : PTPRO | ||||||||||||||||||||||||
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| 종. | 인간 | 마우스 | |||||||||||||||||||||||
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| 앙상블 | |||||||||||||||||||||||||
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| RefSeq(mRNA) |
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| RefSeq(단백질) |
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| 장소(UCSC) | Chr 12: 15.32 ~15.6 Mb | Chr 6: 137.23 ~137.44 Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키데이터 | |||||||||||||||||||||||||
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수용체형 티로신단백질인산가수분해효소 O는 PTPRO [5][6][7]유전자에 의해 인체 내에서 암호화되는 효소이다.
이 유전자는 특징적인 모티브를 가진 단일 세포내 촉매 도메인을 포함하는 수용체형 단백질 티로신 포스파타아제를 코드한다.트랜스막 도메인을 가진 유전자 생성물은 일체형 막 단백질이다.단백질의 다른 동질 형태를 인코딩하는 몇 가지 대체적으로 스플라이스된 전사 변이가 설명되었다.이러한 변형은 조직 고유의 [7]발현을 나타냅니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000151490 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000030223 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J Biol Chem. 269 (31): 19953–62. doi:10.1016/S0021-9258(17)32113-0. PMID 7519601.
- ^ Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE (Oct 1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics. 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166.
- ^ a b "Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O".
추가 정보
- Seimiya H, Sawabe T, Inazawa J, Tsuruo T (1995). "Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents". Oncogene. 10 (9): 1731–8. PMID 7753550.
- Feito MJ, Bragardo M, Buonfiglio D, et al. (1997). "gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules". Int. Immunol. 9 (8): 1141–7. doi:10.1093/intimm/9.8.1141. PMID 9263011.
- Avraham S, London R, Tulloch GA, et al. (1998). "Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells". Gene. 204 (1–2): 5–16. doi:10.1016/S0378-1119(97)00420-4. PMID 9434160.
- Taniguchi Y, London R, Schinkmann K, et al. (1999). "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor". Blood. 94 (2): 539–49. doi:10.1182/blood.V94.2.539. PMID 10397721.
- Aguiar RC, Yakushijin Y, Kharbanda S, et al. (1999). "PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest". Blood. 94 (7): 2403–13. doi:10.1182/blood.V94.7.2403.419k39_2403_2413. PMID 10498613.
- Wang Z, Bhattacharya N, Meyer MK, et al. (2001). "Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells". Arch. Biochem. Biophys. 390 (1): 9–18. doi:10.1006/abbi.2001.2370. PMID 11368509.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Motiwala T, Kutay H, Ghoshal K, et al. (2004). "Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13844–9. Bibcode:2004PNAS..10113844M. doi:10.1073/pnas.0405451101. PMC 518843. PMID 15356345.
- Chen L, Juszczynski P, Takeyama K, et al. (2007). "Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation". Blood. 108 (10): 3428–33. doi:10.1182/blood-2006-03-013821. PMID 16888096.
- Motiwala T, Majumder S, Kutay H, et al. (2007). "Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia". Clin. Cancer Res. 13 (11): 3174–81. doi:10.1158/1078-0432.CCR-06-1720. PMC 3074612. PMID 17545520.
- Tian J, Wang HP, Mao YY, et al. (2007). "Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy". J. Int. Med. Res. 35 (3): 338–45. doi:10.1177/147323000703500308. PMID 17593862.
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