PTPRF

PTPRF
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1 LAR, 2DJU, 2EDX, 2EDY, 2YD5, 2YD8, 4N5U, 2DN7
식별자
에일리어스	PTPRF, LAR, BNAH2, 단백질티로신인산가수분해효소, 수용체형 F, 단백질티로신인산가수분해효소수용체형 F
외부 ID	OMIM : 179590 MGI : 102695 HomoloGene : 20623 GenCard : PTPRF
유전자 위치(인간)
크르.	1번 염색체(인간)
끝.	43,623,666 bp
유전자 위치(마우스)
크르.	4번 염색체(쥐)
끝.	118,291,405 bp
RNA발현패턴
	상단 표시 위치:
	기관지 상피 세포; ; 니플; ; 이하선; ; 모낭; ; 생식 상피; ; 제주날 점막; ; 외음부; ; 인간의 음경; ; 부고환 말뭉치; ; 유즙관;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	콘드로이틴황산프로테오글리칸결합; 헤파린 결합; 인단백인산가수분해효소활성; 포스파타아제활성; GO:0032403 단백질 함유 복합결합; 단백질티로신인산가수분해효소활성; 막관통수용체단백질티로신인산가수분해효소활성; 가수분해효소활성; 세포접착분자결합;
셀룰러 컴포넌트	막의 적분 성분; 막; 혈장막의 적분 성분; 신경세포체; 뉴런 투영; 세포외 엑소좀; 혈장막;
생물학적 과정	뉴런투영재생; 축삭 재생 조절; 수용체 결합의 음성 조절; 뉴런 투영 발달 조절; 단백질 탈인산화; 막간수용체단백질티로신포스파타아제신호전달경로; 세포 접착; 펩티딜티로신탈인산화; 세포이동; 탈인산화; 시냅스막 접착;
	출처:아미고 / QuickGO
맞춤법
	5792
	19268
	ENSG00000142949
	ENSMUSG000033295
	P10586
	A2A8L5
NM_002840; NM_130440; NM_001329137; NM_001329138; NM_001329139;
	NM_001329140
	NM_011213
NP_001316066; NP_001316067; NP_001316068; NP_001316069; NP_002831;
	NP_569707
	NP_035343
	위키데이터
인간 보기/편집	마우스 표시/편집

수용체형 티로신단백질인산가수분해효소 F는 PTPRF ^[5]^[6]유전자에 의해 인체 내에서 암호화되는 효소이다.

이 유전자에 의해 암호화된 단백질은 단백질 티로신 포스파타아제(PTP) 계열의 구성원이다.PTP는 세포 성장, 분화, 유사분열 주기, 그리고 발암성 변형을 포함한 다양한 세포 과정을 조절하는 신호 분자로 알려져 있다.이 PTP는 세포외 영역, 단일 막간 영역 및 2개의 탠덤 세포질내 촉매 도메인을 가지며, 따라서 수용체형 PTP를 나타낸다.세포외 영역은 3개의 Ig 유사 도메인과 신경세포 접착 분자와 유사한 9개의 비 Ig 유사 도메인을 포함한다.이 PTP는 아데렌스 접합부의 상피 세포-세포 접촉 조절과 베타-카테닌 신호 조절에서 기능하는 것으로 나타났다.이 단백질의 증가된 발현 수준은 비만, 인슐린 내성 개인의 인슐린 반응성 조직에서 발견되었으며 인슐린 저항성의 병인에 기여할 수 있다.다른 단백질을 코드하는 이 유전자의 두 가지 대체적으로 결합된 전사 변형이 ^[6]보고되었다.

상호 작용

PTPRF는 베타-카테닌^[7]^[8] 및 리핀-알파-1과 ^[9]^[10]^[11]상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000142949 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000033295 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Harder KW, Saw J, Miki N, Jirik F (Nov 1995). "Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line". Genomics. 27 (3): 552–3. doi:10.1006/geno.1995.1092. PMID 7558042.
^ ^a ^b "Entrez Gene: PTPRF protein tyrosine phosphatase, receptor type, F".
^ Bonvini P, An WG, Rosolen A, Nguyen P, Trepel J, Garcia de Herreros A, Dunach M, Neckers LM (Feb 2001). "Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription". Cancer Res. 61 (4): 1671–7. PMID 11245482.
^ Aicher B, Lerch MM, Müller T, Schilling J, Ullrich A (Aug 1997). "Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing". J. Cell Biol. 138 (3): 681–96. doi:10.1083/jcb.138.3.681. PMC 2141638. PMID 9245795.
^ Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.
^ Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Jun 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–38. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401. PMID 7796809.
^ Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jun 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.

추가 정보

Chernoff J (1999). "Protein tyrosine phosphatases as negative regulators of mitogenic signaling". J. Cell. Physiol. 180 (2): 173–81. doi:10.1002/(SICI)1097-4652(199908)180:2<173::AID-JCP5>3.0.CO;2-Y. PMID 10395287.
Hashimoto N, Feener EP, Zhang WR, Goldstein BJ (1992). "Insulin receptor protein-tyrosine phosphatases. Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain". J. Biol. Chem. 267 (20): 13811–4. doi:10.1016/S0021-9258(19)49639-7. PMID 1321126.
Jirik FR, Harder KW, Melhado IG, Anderson LL, Duncan AM (1993). "The gene for leukocyte antigen-related tyrosine phosphatase (LAR) is localized to human chromosome 1p32, a region frequently deleted in tumors of neuroectodermal origin". Cytogenet. Cell Genet. 61 (4): 266–8. doi:10.1159/000133418. PMID 1486801.
Streuli M, Krueger NX, Thai T, Tang M, Saito H (1990). "Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR". EMBO J. 9 (8): 2399–407. doi:10.1002/j.1460-2075.1990.tb07415.x. PMC 552264. PMID 1695146.
Streuli M, Krueger NX, Tsai AY, Saito H (1989). "A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8698–702. Bibcode:1989PNAS...86.8698S. doi:10.1073/pnas.86.22.8698. PMC 298355. PMID 2554325.
Streuli M, Krueger NX, Hall LR, Schlossman SF, Saito H (1988). "A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen". J. Exp. Med. 168 (5): 1523–30. doi:10.1084/jem.168.5.1523. PMC 2189122. PMID 2972792.
Schaapveld RQ, van den Maagdenberg AM, Schepens JT, Weghuis DO, Geurts van Kessel A, Wieringa B, Hendriks WJ (1995). "The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization". Genomics. 27 (1): 124–30. doi:10.1006/geno.1995.1014. hdl:2066/21329. PMID 7665159.
Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–38. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401. PMID 7796809.
O'Grady P, Krueger NX, Streuli M, Saito H (1994). "Genomic organization of the human LAR protein tyrosine phosphatase gene and alternative splicing in the extracellular fibronectin type-III domains". J. Biol. Chem. 269 (40): 25193–9. doi:10.1016/S0021-9258(17)31516-8. PMID 7929208.
Pulido R, Serra-Pagès C, Tang M, Streuli M (1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.
Liu X, Vega QC, Decker RA, Pandey A, Worby CA, Dixon JE (1996). "Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities". J. Biol. Chem. 271 (10): 5309–12. doi:10.1074/jbc.271.10.5309. PMID 8621380.
Debant A, Serra-Pagès C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (1996). "The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5466–71. Bibcode:1996PNAS...93.5466D. doi:10.1073/pnas.93.11.5466. PMC 39269. PMID 8643598.
Zhang WR, Li PM, Oswald MA, Goldstein BJ (1996). "Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR". Mol. Endocrinol. 10 (5): 575–84. doi:10.1210/mend.10.5.8732688. PMID 8732688.
Tabiti K, Cui L, Chhatwal VJ, Moochhala S, Ngoi SS, Pallen CJ (1996). "Novel alternative splicing predicts a secreted extracellular isoform of the human receptor-like protein tyrosine phosphatase LAR". Gene. 175 (1–2): 7–13. doi:10.1016/0378-1119(96)00113-8. PMID 8917069.
Ahmad F, Goldstein BJ (1997). "Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells". J. Biol. Chem. 272 (1): 448–57. doi:10.1074/jbc.272.1.448. PMID 8995282.
Aicher B, Lerch MM, Müller T, Schilling J, Ullrich A (1997). "Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing". J. Cell Biol. 138 (3): 681–96. doi:10.1083/jcb.138.3.681. PMC 2141638. PMID 9245795.
Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.
O'Grady P, Thai TC, Saito H (1998). "The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR". J. Cell Biol. 141 (7): 1675–84. doi:10.1083/jcb.141.7.1675. PMC 2133008. PMID 9647658.
Chiplunkar S, Chamblis K, Chwa M, Rosenberg S, Kenney MC, Brown DJ (1999). "Enhanced expression of a transmembrane phosphotyrosine phosphatase (LAR) in keratoconus cultures and corneas". Exp. Eye Res. 68 (3): 283–93. doi:10.1006/exer.1998.0604. PMID 10079136.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000142949 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000033295 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7558042-5] Harder KW, Saw J, Miki N, Jirik F (Nov 1995). "Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line". Genomics. 27 (3): 552–3. doi:10.1006/geno.1995.1092. PMID 7558042.

[entrez-6] "Entrez Gene: PTPRF protein tyrosine phosphatase, receptor type, F".

[pmid11245482-7] Bonvini P, An WG, Rosolen A, Nguyen P, Trepel J, Garcia de Herreros A, Dunach M, Neckers LM (Feb 2001). "Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription". Cancer Res. 61 (4): 1671–7. PMID 11245482.

[pmid9245795-8] Aicher B, Lerch MM, Müller T, Schilling J, Ullrich A (Aug 1997). "Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing". J. Cell Biol. 138 (3): 681–96. doi:10.1083/jcb.138.3.681. PMC 2141638. PMID 9245795.

[pmid8524829-9] Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.

[pmid7796809-10] Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Jun 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–38. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401. PMID 7796809.

[pmid9624153-11] Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jun 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.

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PTPRF

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상호 작용

레퍼런스

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