호모 사피엔스 종의 단백질 코드 유전자
인터페론유도 GTP결합단백질 MX2 /MXB는 [3] [4] [5] MX2유전자 에 의해 인체에서 암호화되는 단백질 이다.
이 유전자에 의해 코드된 단백질은 핵과 세포질 형태를 가지고 있으며, 다이나믹 패밀리와 대형 GTPases 패밀리의 구성원이다. 핵 형태는 핵 외피 아래의 헤테로크로마틴 영역에 입상 패턴으로 국부화된다. 핵형식의 아미노 말단에는 핵국재신호(NLS)가 존재하지만 대체 번역 개시 코돈을 사용하기 때문에 세포질형식은 결여되어 있다.
항바이러스 활성 이 단백질은 인터페론 알파에 의해 상향 조절되지만 유사한 마이코바이러스 내성 단백질 [5]
MX2/[6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000183486 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Aebi M, Fäh J, Hurt N, Samuel CE, Thomis D, Bazzigher L, et al. (November 1989). "cDNA structures and regulation of two interferon-induced human Mx proteins" . Molecular and Cellular Biology . 9 (11): 5062–72. doi :10.1128/mcb.9.11.5062 . PMC 363658 PMID 2481229 . ^ Melén K, Keskinen P, Ronni T, Sareneva T, Lounatmaa K, Julkunen I (September 1996). "Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope" . The Journal of Biological Chemistry . 271 (38): 23478–86. doi :10.1074/jbc.271.38.23478 PMID 8798556 . ^ a b "Entrez Gene: MX2 myxovirus (influenza virus) resistance 2 (mouse)" .^ Liu Z, Pan Q, Ding S, Qian J, Xu F, Zhou J, et al. (October 2013). "The interferon-inducible MxB protein inhibits HIV-1 infection" . Cell Host & Microbe . 14 (4): 398–410. doi :10.1016/j.chom.2013.08.015 PMID 24055605 . ^ Kane M, Yadav SS, Bitzegeio J, Kutluay SB, Zang T, Wilson SJ, et al. (October 2013). "MX2 is an interferon-induced inhibitor of HIV-1 infection" . Nature . 502 (7472): 563–6. Bibcode :2013Natur.502..563K . doi :10.1038/nature12653 . PMC 3912734 PMID 24121441 . ^ Goujon C, Moncorgé O, Bauby H, Doyle T, Ward CC, Schaller T, et al. (October 2013). "Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection" . Nature . 502 (7472): 559–62. Bibcode :2013Natur.502..559G . doi :10.1038/nature12542 . PMC 3808269 PMID 24048477 . ^ Alvarez FJ, He S, Perilla JR, Jang S, Schulten K, Engelman AN, et al. (September 2017). "CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction" . Science Advances . 3 (9): e1701264. Bibcode :2017SciA....3E1264A . doi :10.1126/sciadv.1701264 . PMC 5600524 PMID 28929138 . ^ Merindol N, Berthoux L (2015). "Restriction Factors in HIV-1 Disease Progression". Current HIV Research . 13 (6): 448–61. doi :10.2174/1570162x13666150608104412 . PMID 26051387 . ^ Haller O, Staeheli P, Schwemmle M, Kochs G (March 2015). "Mx GTPases: dynamin-like antiviral machines of innate immunity". Trends in Microbiology . 23 (3): 154–63. doi :10.1016/j.tim.2014.12.003 . PMID 25572883 . ^ Chintala K, Mohareer K, Banerjee S (2021). "Dodging the Host Interferon-Stimulated Gene Mediated Innate Immunity by HIV-1: A Brief Update on Intrinsic Mechanisms and Counter-Mechanisms" . Frontiers in Immunology . 12 : 716927. doi :10.3389/fimmu.2021.716927 . PMC 8358655 PMID 34394123 . ^ Crameri M, Bauer M, Caduff N, Walker R, Steiner F, Franzoso FD, et al. (May 2018). "MxB is an interferon-induced restriction factor of human herpesviruses" . Nature Communications . 9 (1): 1980. Bibcode :2018NatCo...9.1980C . doi :10.1038/s41467-018-04379-2 . PMC 5958057 PMID 29773792 . ^ Schilling M, Bulli L, Weigang S, Graf L, Naumann S, Patzina C, et al. (September 2018). Sandri-Goldin RM (ed.). "Human MxB Protein Is a Pan-herpesvirus Restriction Factor" . Journal of Virology . 92 (17): e01056–18, /jvi/92/17/e01056–18.atom. doi :10.1128/JVI.01056-18 . PMC 6096802 PMID 29950411 . ^ Jaguva Vasudevan AA, Bähr A, Grothmann R, Singer A, Häussinger D, Zimmermann A, Münk C (September 2018). "MXB inhibits murine cytomegalovirus" . Virology . 522 : 158–167. doi :10.1016/j.virol.2018.07.017 PMID 30032029 . ^ Staeheli P, Haller O (December 2018). Ulrike Gack MU (ed.). "Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1" . Journal of Virology . 92 (24): e00709–18, /jvi/92/24/e00709–18.atom. doi :10.1128/JVI.00709-18 . PMC 6258936 PMID 30258007 .
추가 정보 Horisberger MA, McMaster GK, Zeller H, Wathelet MG, Dellis J, Content J (March 1990). "Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter" . Journal of Virology . 64 (3): 1171–81. doi :10.1128/JVI.64.3.1171-1181.1990 . PMC 249231 PMID 2154602 . Horisberger MA, Wathelet M, Szpirer J, Szpirer C, Islam Q, Levan G, et al. (March 1988). "cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene". Somatic Cell and Molecular Genetics . 14 (2): 123–31. doi :10.1007/BF01534397 . PMID 3162334 . S2CID 31805827 . al-Masri AN, Werfel T, Jakschies D, von Wussow P (February 1997). "Intracellular staining of Mx proteins in cells from peripheral blood, bone marrow and skin" . Molecular Pathology . 50 (1): 9–14. doi :10.1136/mp.50.1.9 . PMC 379572 PMID 9208807 . Melén K, Julkunen I (December 1997). "Nuclear cotransport mechanism of cytoplasmic human MxB protein" . The Journal of Biological Chemistry . 272 (51): 32353–9. doi :10.1074/jbc.272.51.32353 PMID 9405443 . Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, et al. (May 2000). "The DNA sequence of human chromosome 21" . Nature . 405 (6784): 311–9. Bibcode :2000Natur.405..311H . doi :10.1038/35012518 PMID 10830953 . Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proceedings of the National Academy of Sciences of the United States of America . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Tanaka S, Honda Y, Honda M (August 2007). "Identification of differentially expressed genes in blood cells of narcolepsy patients" . Sleep . 30 (8): 974–9. doi :10.1093/sleep/30.8.974 . PMC 1978392 PMID 17702266 .
