호모 사피엔스에서 발견되는 포유류의 단백질
인간 유전자 UBR1은 효소 유비퀴틴-단백질 연결효소 E3 성분 n-인식 인 1을 코드한다 .[5] [6]
N-end 규칙 경로는 유비퀴틴 시스템의 단백질 분해 경로 중 하나이다. 이 유전자에 의해 코드된 이 경로의 인식 성분은 기질 단백질의 불안정한 N 말단 잔기에 결합하고 기질 연결 다중 유비퀴틴 사슬의 형성에 참여한다. 이는 결국 기질 단백질의 분해로 이어진다. 이 기록에 기술된 단백질은 RING형 아연 핑거와 UBR형 아연 핑거를 가지고 있습니다. 이 유전자의 돌연변이는 요한슨-블리자드 [6]
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