자동포기 관련 12 는 인간에서 ATG12 유전자 에 의해 암호화된 단백질 이다.[5] [6]
오토파기는 오르가넬을 포함한 세포질 성분은 자가포도솜이라고 하는 이중 기억 구조로 둘러싸여 분해하기 위해 라이소솜이나 바쿠올에 전달되는 대량 단백질 분해 과정이다. ATG12는 자가포자기에 관여하는 효모 단백질의 인간 호몰로지(Mizushima et al., 1998)이다. [OMIM에 의해 제공][6]
자동포기 는 유비퀴틴 과 같은 결합 시스템을 통해 Atg12에서 ATG5 까지 단백질 공동 부착을 요구한다. Atg12-Atg5 결합은 ATG8 이 지질인산염다닐타놀라민 에 결합하도록 촉진한다.[7]
atg12는 사멸 에 연루된 것으로 밝혀졌다. 이 단백질은 Bcl-2 계열 의 항중독성 구성원과 상호작용을 통해 사멸을 촉진한다.[8]
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