UBA1

UBA1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	4P22
식별자
에일리어스	UBA1, A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X, 유비퀴틴류 수식효소 1
외부 ID	OMIM: 314370 MGI: 98890 HomoloGene: 22002 GeneCard: UBA1
유전자 위치(인간)
크르.	X염색체(인간)
끝.	47,215,128 bp
유전자 위치(마우스)
크르.	X염색체(쥐)
끝.	20,549,418 bp
RNA발현패턴
	상단 표시 위치:
	신장수질; ; 갑상선 우엽; ; 신경절 융기; ; 니플; ; 후중심회; ; 우측 자궁관; ; 척수 신경절; ; 삼차신경절; ; 갑상선 좌엽; ; 혀 윗면;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	뉴클레오티드 결합; 리가아제활성; GO:0001948 단백질 결합; 효소활성활성화유비퀴틴양수식제; ATP 결합; 유비퀴틴활성화효소활성화; RNA결합;
셀룰러 컴포넌트	세포질; 조내소체막; 데스모솜; 헤테로크로마틴; 리소좀막; 미토콘드리아; 엔도솜막; 세포외 엑소좀; 핵; 핵소체; 세포;
생물학적 과정	DNA 손상 자극에 대한 세포 반응; 세포단백질수식과정; 단백질유비퀴티네이션; 유비퀴틴의존성 단백질 이화 과정; 소단백질 결합에 의한 단백질 수식; 대사;
	출처:아미고 / QuickGO
맞춤법
	7317
	22201
	ENSG00000130985
	ENSMUSG00000001924
	P22314; Q5JRS2
	Q02053
	NM_003334; NM_153280
	NM_001136085; NM_001276316; NM_001276317; NM_009457
	NP_003325; NP_695012
	NP_001129557; NP_001263245; NP_001263246; NP_033483
	위키데이터
인간 보기/편집	마우스 표시/편집

유비퀴틴유사수식활성화효소1(UBA1)은 UBA1유전자에 ^[5]^[6]의해 인간에게 코드되는 효소이다.UBA1은 많은 다른 생물학적 ^[5]^[7]과정 중에서 단백질 접힘 및 분해를 위한 유비쿼티네이션 및 NEDD8 경로에 관여한다.이 단백질은 X-연관 척추근육위축증 2형, 신경변성질환, ^[8]^[9]암과 관련이 있다.

구조.

진

UBA1 유전자는 31개의 엑손으로 구성된 염색체 밴드 Xp11.23에 위치한다.

단백질

유비퀴틴(Ub)에 대한 UBA1은 110~120kDa 단량체 단백질이며, 유비퀴틴 유사 단백질(Ubls) NEDD8 및 SMO에 대한 UBA1은 분자량이 유사한 헤테로다이머 복합체이다.모든 진핵생물 UBA1은 Ub용 UBA1의 N말단 및 C말단 절반에서 각각 1회 발생하는 세균 MoeB ^[10]및 TiF 단백질로부터 유도되는 도메인의 2배 반복을 포함하거나, NEDD8용 UBA1 및 SMO용 ^[11]UBA1의 별도 서브유닛은 4개로 구성된다.첫째, 아데닐화 도메인 두 MoeB/ThiF-homology 모티브의 ATP와 Ub을 하나로 묶는 후자의;구성되어[12][13][14]두번째, 촉매 시스테인 half-domains는 함유하고 있는 E1활성 부위 시스테인 삽입의 아데닐화 도메인;[15]셋째,four-helix 다발을 나타내는 두번째 삽입에 비활성 adenylatio.n도메인이고첫 번째 촉매 시스테인 반 도메인, 그리고 네 번째, 특정 E2s를 ^[13]^[16]^[17]모집하는 C 말단 유비퀴틴-폴드 도메인을 중간적으로 따른다.

기능.

이 유전자에 의해 암호화된 단백질은 세포 단백질의 분해를 표시하기 위해 유비퀴틴 결합 또는 유비퀴티네이션의 첫 단계를 촉매합니다.구체적으로 UBA1은 유비퀴틴의 ATP 의존성 아데닐화를 촉매하여 둘 사이에 티오에스테르 결합을 형성한다.또한 Ub ^[8]^[9]^[18]캐리어로서 유비쿼티화의 후속 단계에도 계속 참여하고 있습니다.인간의 유비퀴틴 활성화 효소는 UBA1과 UBA6 두 가지뿐이며,^[8]^[9]^[18] 따라서 UBA1은 인간의 단백질 유비퀴티화를 크게 담당한다.UBA1은 유비쿼티제이션의 중심 역할을 통해 세포주기 조절, 세포내구증, 신호전달, 아포토시스, DNA 손상 복구 및 전사 ^[8]^[9]조절과 연계되어 있다.또한, UBA1은 NEDD8 경로를 조절하는 데 도움을 주고, 따라서 단백질 접힘에 관여하며,^[7] 스트레스 동안 유비퀴틴 수준의 고갈을 완화한다.

임상적 의의

UBA1의 돌연변이는 X-연결척수근위축증 타입 ^[5]2와 관련된다.UBA1은 또한 암과 종양뿐만 아니라 척추근육위축증을 ^[19]포함한 다른 신경변성 질환에도 관련되어 있다.UBA1은 여러 생물학적 과정에 관여하기 때문에 UBA1을 억제하는 것은 정상 세포에도 손상을 줄 수 있다는 우려가 있다.그럼에도 불구하고, 백혈병과 쥐에서 UBA1 억제제의 사전 임상 시험 정상 세포로, 그리고 다른 마약의 성공 likewise 지원 다면 발현성의 목표 암에 UBA1 억제제 사용의 안전성을 목표로 하고 treatment[8][9]게다가 UBA1 억제제 Largazole을 비롯한 케톤과 에스테르 derivativ 추가적인 독성 효과 밝혔다.에스, p참조적으로 E1 경로의 아데닐화 단계 동안 Ub 및 UBA1의 결속을 차단하여 정상 세포보다 암을 표적화한다.유사한 메커니즘에 따라 기능하는 NEDD8 활성화 효소 억제제인 MLN4924는 현재 1상 임상시험을 ^[9]진행 중이다.

2020년에 확인되고 VEXAS 증후군(VACUOLES, E1 효소, X 연결, 자가 염증, 체세포)이라는 이름의 자가 염증 상태는 유비쿼티화를 ^[20]시작하는 E1 효소인 UBA1의 메티오닌41 돌연변이에 기인한다.

상호 작용

UBA1은 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000130985 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000001924 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c "Entrez Gene: ubiquitin-like modifier activating enzyme 1".
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^ Powis, Rachael A.; Karyka, Evangelia; Boyd, Penelope; Côme, Julien; Jones, Ross A.; Zheng, Yinan; Szunyogova, Eva; Groen, Ewout J.N.; Hunter, Gillian; Thomson, Derek; Wishart, Thomas M.; Becker, Catherina G.; Parson, Simon H.; Martinat, Cécile; Azzouz, Mimoun; Gillingwater, Thomas H. (2016). "Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy" (PDF). JCI Insight. 1 (11): e87908. doi:10.1172/jci.insight.87908. PMC 5033939. PMID 27699224.
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추가 정보

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외부 링크

UBE1+단백질+미국 국립의학도서관의 의학 주제 제목(MeSH)

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000130985 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000001924 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ubiquitin-like modifier activating enzyme 1".

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