UBE2D2 사용 가능한 구조물 PDB 직교 검색: PDBe RCSB PDB ID 코드 목록 1UR6 , 1W4U , 2CLW , 2ESK , 2ESO , 2ESP , 2ESQ , 3A33 , 3JVZ , 3JW0 , 3L1Y , 3TGD , 3ZNI , 4A49 , 4A4B , 4A4C , 4AUQ , 4DDG , 4LDT , 4V3K , 4V3L , 4WZ3 , 5D1L , 5D1K , 5D0M , 5D0K , 5D1M , 5EDV
식별자 별칭 UBE2D2 외부 ID OMIM : 602962 MGI : 1930715 HomoloGene : 2506 GeneCard : UBE2D2 EC 번호 2.3.2.24 직교체 종 인간 마우스 엔트레스 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 위치(UCSC) Cr 5: 139.53 – 139.63Mb Cr 18: 35.77 – 35.81Mb PubMed 검색[3] [4] 위키다타
유비퀴틴결합효소 E2 D2 는 인간에서 UBE2D2 유전자 에 의해 암호화된 단백질 이다.[5] [6]
함수 유비퀴틴으로 단백질을 변형시키는 것은 비정상적이거나 단명하는 단백질을 분해 대상으로 삼기 위한 중요한 세포 메커니즘이다. 유비퀴티테이션은 적어도 세 종류의 효소를 포함한다: 유비퀴틴 활성 효소, 또는 E1s, 유비퀴틴 컨쥬깅 효소, E2s, 유비퀴틴-단백질 묶음, 또는 E3. 이 유전자는 E2 ubiquitin-conjugging 효소 계열의 구성원을 암호로 한다. 이 효소는 E3 유비퀴틴-단백질 리가아제에 의해 유도되는 종양억제제 단백질 p53의 유비쿼터스화에 기능한다. 이 유전자에 대해 두 개의 다른 분할된 대본 변형이 발견되었고 그것들은 구별되는 등소 형태를 암호화한다.[6]
상호작용 UBE2D2는 다음과 상호 작용하는 것으로 나타났다.
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PDB 갤러리
1ur6 : UBCH5B-CONT4 복합체의 NMR 기반 구조모델
1w4u : 유비쿼터스ITIN 결합효소 UBCH5B의 NMR 솔루션 구조
1z2u : 1.1선충의 유비퀴틴 콘주게팅 효소(ubc-2) 결정구조: 기능적, 진화적 유의성
2c4o : 인간 유비퀴틴-콘쥬깅 효소 UBCH5B의 결정구조
2esk : 휴먼 유비퀴틴-콘쥬깅 효소(E2) UbcH5b, 야생형
2eso : 휴먼 유비퀴틴-콘쥬깅 효소(E2) UbcH5b 돌연변이 Ile37알라
2esp : 휴먼 유비퀴틴콘쥬게팅효소(E2) UbcH5b 돌연변이 Ile88알라
2esq : 휴먼 유비퀴틴-콘쥬깅 효소(E2) UbcH5b 돌연변이 Ser94Gly
2fuh : UbcH5c/Ub 비동결 복합체의 용액구조
