DNAJA1

DNAJA1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2LO1, 2M6Y
식별자
에일리어스	DNAJA1, DJ-2, DjA1, HDJ2, HSDJ, HSPF4, NEDD7, hDJ-2, HSJ-2, DnaJ 히트쇼크단백질패밀리(Hsp40)A1
외부 ID	OMIM : 602837 MGI : 1270129 HomoloGene : 55588 GenCard : DNAJA1
유전자 위치(인간)
크르.	9번 염색체(인간)
끝.	33,039,907 bp
유전자 위치(마우스)
크르.	4번 염색체(쥐)
끝.	40,440,140 bp
RNA발현패턴
	상단 표시 위치:
	난모세포; ; 기관지 상피 세포; ; 신경절 융기; ; 양수; ; 이차 난모세포; ; 자궁내막간질세포; ; 폐하엽; ; 상전정핵; ; 전전두피질; ; 두정 흉막;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	샤페론 결합; 열충격단백질결합; 전개단백질결합; C3HC4 타입 RING 핑거 도메인바인딩; 금속 이온 결합; 저밀도 리포단백질입자수용체결합; Hsp70 단백질 결합; GO:0001948 단백질 결합; G단백질결합수용체결합; ATP 결합; 유비퀴틴단백질리가수분해효소결합; Tat단백질결합; ATP효소활성화제활성화제;
셀룰러 컴포넌트	세포질; 막; 세포막내소기관; 유비퀴틴리가아제복합체; 미토콘드리아; 소포체 세포질측; 소포체; 세포질핵주위영역; 세포외 엑소좀; 핵; 미소관 세포골격; 세포;
생물학적 과정	편모 정자 운동성; 안드로겐수용체신호경로; 단백질수송조절; 아포토시스 과정의 음성 조절; 열에 대한 반응; 독소 수송; 단백질 유비퀴티네이션 음성 조절; 전개 단백질에 대한 반응; 단백질 접힘; 정자 형성; 아포토시스 과정의 양성 조절; 미토콘드리아에 대한 단백질 국재화; JUN인산화효소활성음성조절; 미토콘드리아에 대한 단백질 위치 결정의 음성 조절; 질산성 스트레스 유도 내인성 아포토시스 신호 경로의 음성 조절; ATP 의존성 활성의 양성 조절;
	출처:아미고 / QuickGO
맞춤법
	3301
	15502
	ENSG000086061
	ENSMUSG000028410
	P31689
	P63037
	NM_001539; NM_001314039
	NM_001164671; NM_001164672; NM_008298
	NP_001300968; NP_001530
	NP_001158143; NP_001158144; NP_032324
	위키데이터
인간 보기/편집	마우스 표시/편집

DnaJ 호몰로그 서브패밀리 A멤버 1은 DNAJA1유전자에 ^[5]^[6]^[7]의해 인체 내에서 암호화되는 단백질이다.

상호 작용

DNAJA1은 PTTG1과 ^[8]상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000086061 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000028410 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chellaiah A, Davis A, Mohanakumar T (August 1993). "Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein". Biochim Biophys Acta. 1174 (1): 111–3. doi:10.1016/0167-4781(93)90103-k. PMID 8334160.
^ Ohtsuka K, Hata M (January 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones. 5 (2): 98–112. PMC 312896. PMID 11147971.
^ "Entrez Gene: DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1".
^ Pei, L (January 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J. Biol. Chem. UNITED STATES. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. ISSN 0021-9258. PMID 9915854.

추가 정보

Oh S, Iwahori A, Kato S (1993). "Human cDNA encoding DnaJ protein homologue". Biochim. Biophys. Acta. 1174 (1): 114–6. doi:10.1016/0167-4781(93)90104-l. PMID 8334161.
Kanazawa M, Terada K, Kato S, Mori M (1997). "HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria". J. Biochem. 121 (5): 890–5. doi:10.1093/oxfordjournals.jbchem.a021670. PMID 9192730.
Davis AR, Alevy YG, Chellaiah A, et al. (1998). "Characterization of HDJ-2, a human 40 kD heat shock protein". Int. J. Biochem. Cell Biol. 30 (11): 1203–21. doi:10.1016/S1357-2725(98)00091-0. PMID 9839446.
Pei L (1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J. Biol. Chem. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. PMID 9915854.
Meacham GC, Lu Z, King S, et al. (1999). "The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis". EMBO J. 18 (6): 1492–505. doi:10.1093/emboj/18.6.1492. PMC 1171238. PMID 10075921.
Terada K, Mori M (2000). "Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70". J. Biol. Chem. 275 (32): 24728–34. doi:10.1074/jbc.M002021200. PMID 10816573.
Jana NR, Tanaka M, Wang G, Nukina N (2000). "Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity". Hum. Mol. Genet. 9 (13): 2009–18. doi:10.1093/hmg/9.13.2009. PMID 10942430.
Bao YP, Cook LJ, O'Donovan D, et al. (2002). "Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy". J. Biol. Chem. 277 (14): 12263–9. doi:10.1074/jbc.M109633200. PMID 11796717.
Hernández MP, Chadli A, Toft DO (2002). "HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor". J. Biol. Chem. 277 (14): 11873–81. doi:10.1074/jbc.M111445200. PMID 11809754.
Imai Y, Soda M, Hatakeyama S, et al. (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hanai R, Mashima K (2004). "Characterization of two isoforms of a human DnaJ homologue, HSJ2". Mol. Biol. Rep. 30 (3): 149–53. doi:10.1023/A:1024916223616. PMID 12974469. S2CID 24105834.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Marschang P, Brich J, Weeber EJ, et al. (2004). "Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1". Mol. Cell. Biol. 24 (9): 3782–93. doi:10.1128/MCB.24.9.3782-3793.2004. PMC 387731. PMID 15082773.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Hu Y, Zhou Z, Huang X, et al. (2005). "Expression of a novel DnaJA1 alternative splicing in human testis and sperm". Int. J. Androl. 27 (6): 343–9. doi:10.1111/j.1365-2605.2004.00492.x. PMID 15595953.

인간 염색체 9번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000086061 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000028410 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8334160-5] Chellaiah A, Davis A, Mohanakumar T (August 1993). "Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein". Biochim Biophys Acta. 1174 (1): 111–3. doi:10.1016/0167-4781(93)90103-k. PMID 8334160.

[pmid11147971-6] Ohtsuka K, Hata M (January 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones. 5 (2): 98–112. PMC 312896. PMID 11147971.

[entrez-7] "Entrez Gene: DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1".

[pmid9915854-8] Pei, L (January 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J. Biol. Chem. UNITED STATES. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. ISSN 0021-9258. PMID 9915854.

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DNAJA1

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상호 작용

레퍼런스

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