CDC34

CDC34
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	2OB4, 3RZ3, 4MDK
식별자
별칭	CDC34, E2-UBC3, UBCH3, UBE2R1, 세포분할 주기 34, 세포분할 주기 34, 유비퀴틴 결합 효소
외부 ID	OMIM: 116948 MGI: 102657 HomoloGene: 55815 GeneCard: CDC34
EC 번호	2.3.2.24
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	542,092 bp
유전자 위치(마우스)
쳇.	10번 염색체(쥐)
끝	79,688,398 bp
RNA 표현 패턴
	표현된 상단
	고환; ; 핏덩어리; ; 전방 뇌하수체;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	전이효소 활동; 뉴클레오티드 결합; GO:1904264, GO:1904822, GO:0090622, GO:0090302 유비퀴틴 단백질 리기아제 활성; 유비쿼터스-유니버셜 트랜스퍼아제 활동; GO:0001948 단백질 결합; ATP 바인딩; 유비퀴틴 결합 효소 활성; 유비퀴틴 단백질 리가제 결합;
셀룰러 컴포넌트	핵의; 핵종의; 세포질; 시토솔; 핵 반점;
생물학적 과정	cAMP 매개 신호의 음의 조절; 인터페론 검출기에 대한 세포 반응; 단백질 다극화; 포함 본체 조립에 대한 긍정적인 규제; 단백질 K48 연결 유비쿼터스화; 뉴런 세포절제 과정에 대한 양성 조절; 세포 단백질 수정 과정; DNA 복제 시작; 세포 순환; 성장 요인에 대한 반응; 프로테아솜 매개 유비퀴틴 단백질 카타볼릭 공정; 단백질의 편재; 유사 세포 주기의 G1/S 전환; 유비퀴틴 함유 단백질 카타볼릭 공정;
	출처:아미고 / 퀵고
직교체
	997
	216150
	ENSG00000099804
	ENSMUSG00000020307
	P49427
	Q8CFI2
	NM_004359
	NM_177613; NM_001359817; NM_001359818
	NP_004350
	NP_808281; NP_001346746; NP_001346747
	위키다타
인간 보기/편집	마우스 보기/편집

CDC34는 인간에게 유비퀴틴결합효소 E2 R1 단백질을 암호화하는 유전자다.^[5]^[6]^[7] 이 단백질은 유비퀴틴 결합 효소 계열의 하나로, 유비퀴틴이 다른 단백질에 공발효소 결합을 촉진한다.^[8]

CDC34는 원래 세포 주기에 필수적인 유전자로 제빵사의 효모에서 작업에 의해 발견되었다.^[9] 효모에 함유된 Cdc34는 유비퀴틴 매개 단백질 분해에 대한 수많은 기질(특히 사이클린 의존성 키나제 억제제 Sic1^[10])을 대상으로 한다.^[11] CDC34는 세포 주기 G1 조절기의 유비쿼터스 매개 분해 및 DNA 복제의 시작에 필요하다.^[7]

상호작용

CDC34는 CSNK2B,^[12] BTRC^[13]^[14] 및 CDK9와 상호작용하는 것으로 나타났다.^[15]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG000099804 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000020307 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Plon SE, Leppig KA, Do HN, Groudine M (November 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proceedings of the National Academy of Sciences of the United States of America. 90 (22): 10484–8. Bibcode:1993PNAS...9010484P. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.
^ Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, et al. (October 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proceedings of the National Academy of Sciences of the United States of America. 102 (42): 15053–8. Bibcode:2005PNAS..10215053G. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.
^ ^a ^b "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".
^ Goebl MG, Yochem J, Jentsch S, McGrath JP, Varshavsky A, Byers B (September 1988). "The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme". Science. 241 (4871): 1331–5. doi:10.1126/science.2842867. PMID 2842867.
^ Dutcher SK, Hartwell LH (February 1982). "The role of S. cerevisiae cell division cycle genes in nuclear fusion". Genetics. 100 (2): 175–84. doi:10.1093/genetics/100.2.175. PMC 1201806. PMID 7049831.
^ King RW, Deshaies RJ, Peters JM, Kirschner MW (December 1996). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. doi:10.1126/science.274.5293.1652. PMID 8939846. S2CID 25369228.
^ Williams KM, Qie S, Atkison JH, Salazar-Arango S, Alan Diehl J, Olsen SK (July 2019). "Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34". Nature Communications. 10 (1): 3296. doi:10.1038/s41467-019-11061-8. PMC 6656757. PMID 31341161.
^ Block K, Boyer TG, Yew PR (November 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". The Journal of Biological Chemistry. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.
^ Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.
^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
^ Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, et al. (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular and Cellular Biology. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.

외부 링크

UCSC 게놈 브라우저의 인간 CDC34 게놈 위치 및 CDC34 유전자 세부 정보 페이지.

추가 읽기

King RW, Deshaies RJ, Peters JM, Kirschner MW (December 1996). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. Bibcode:1996Sci...274.1652K. doi:10.1126/science.274.5293.1652. PMID 8939846. S2CID 25369228.
Pagano M (November 1997). "Cell cycle regulation by the ubiquitin pathway". FASEB Journal. 11 (13): 1067–75. doi:10.1096/fasebj.11.13.9367342. PMID 9367342. S2CID 6368478.
Lisztwan J, Marti A, Sutterlüty H, Gstaiger M, Wirbelauer C, Krek W (January 1998). "Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway". The EMBO Journal. 17 (2): 368–83. doi:10.1093/emboj/17.2.368. PMC 1170388. PMID 9430629.
Song A, Wang Q, Goebl MG, Harrington MA (September 1998). "Phosphorylation of nuclear MyoD is required for its rapid degradation". Molecular and Cellular Biology. 18 (9): 4994–9. doi:10.1128/mcb.18.9.4994. PMC 109084. PMID 9710583.
Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, et al. (May 1999). "Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha". The Journal of Biological Chemistry. 274 (21): 14823–30. doi:10.1074/jbc.274.21.14823. PMID 10329681.
Pati D, Meistrich ML, Plon SE (July 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Molecular and Cellular Biology. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
Seol JH, Feldman RM, Zachariae W, Shevchenko A, Correll CC, Lyapina S, et al. (June 1999). "Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34". Genes & Development. 13 (12): 1614–26. doi:10.1101/gad.13.12.1614. PMC 316801. PMID 10385629.
Read MA, Brownell JE, Gladysheva TB, Hottelet M, Parent LA, Coggins MB, et al. (April 2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha". Molecular and Cellular Biology. 20 (7): 2326–33. doi:10.1128/MCB.20.7.2326-2333.2000. PMC 85397. PMID 10713156.
Reymond F, Wirbelauer C, Krek W (May 2000). "Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase". Journal of Cell Science. 113 ( Pt 10) (10): 1687–94. doi:10.1242/jcs.113.10.1687. PMID 10769200.
Charrasse S, Carena I, Brondani V, Klempnauer KH, Ferrari S (June 2000). "Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway". Oncogene. 19 (26): 2986–95. doi:10.1038/sj.onc.1203618. PMID 10871850.
Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, et al. (July 2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4". Oncogene. 19 (31): 3529–36. doi:10.1038/sj.onc.1203647. PMID 10918611.
Duan W, Sun B, Li TW, Tan BJ, Lee MK, Teo TS (October 2000). "Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo". Gene. 256 (1–2): 113–21. doi:10.1016/S0378-1119(00)00365-6. PMID 11054541.
Block K, Boyer TG, Yew PR (November 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". The Journal of Biological Chemistry. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.
Wu K, Chen A, Tan P, Pan ZQ (January 2002). "The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34". The Journal of Biological Chemistry. 277 (1): 516–27. doi:10.1074/jbc.M108008200. PMID 11675391.
Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, et al. (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular and Cellular Biology. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.
Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.

19번 염색체의 유전자에 관한 이 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG000099804 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000020307 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8248134-5] Plon SE, Leppig KA, Do HN, Groudine M (November 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proceedings of the National Academy of Sciences of the United States of America. 90 (22): 10484–8. Bibcode:1993PNAS...9010484P. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.

[pmid16210246-6] Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, et al. (October 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proceedings of the National Academy of Sciences of the United States of America. 102 (42): 15053–8. Bibcode:2005PNAS..10215053G. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.

[entrez-7] "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".

[goebl_1998-8] Goebl MG, Yochem J, Jentsch S, McGrath JP, Varshavsky A, Byers B (September 1988). "The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme". Science. 241 (4871): 1331–5. doi:10.1126/science.2842867. PMID 2842867.

[dutcher_1982-9] Dutcher SK, Hartwell LH (February 1982). "The role of S. cerevisiae cell division cycle genes in nuclear fusion". Genetics. 100 (2): 175–84. doi:10.1093/genetics/100.2.175. PMC 1201806. PMID 7049831.

[king_1996-10] King RW, Deshaies RJ, Peters JM, Kirschner MW (December 1996). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. doi:10.1126/science.274.5293.1652. PMID 8939846. S2CID 25369228.

[williams_2019-11] Williams KM, Qie S, Atkison JH, Salazar-Arango S, Alan Diehl J, Olsen SK (July 2019). "Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34". Nature Communications. 10 (1): 3296. doi:10.1038/s41467-019-11061-8. PMC 6656757. PMID 31341161.

[pmid11546811-12] Block K, Boyer TG, Yew PR (November 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". The Journal of Biological Chemistry. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.

[pmid12037680-13] Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.

[pmid10531035-14] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.

[pmid11689688-15] Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, et al. (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular and Cellular Biology. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.

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CDC34

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