HSP90B1

HSP90B1
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	4NH9
식별자
별칭	HSP90B1, ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1, 열충격 단백질 90kDa 베타 제품군 1, 열충격 단백질 90 베타 제품군 1
외부 ID	OMIM: 191175 MGI: 98817 HomoloGene: 2476 GeneCard: HSP90B1
유전자 위치(인간)
쳇.	12번 염색체(인간)
끝	103,953,931 bp
유전자 위치(마우스)
쳇.	10번 염색체(쥐)
끝	86,705,509 bp
RNA 표현 패턴
	표현된 상단
	고환; ; 갑상선; ; 뇌하수체; ; 말뭉치 전염병; ; 자궁내막; ; 간 우엽;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	뉴클레오티드 결합; 칼슘 이온 결합; 펴진 단백질 결합; 저밀도 지단백질 입자 수용체 결합; GO:0001948 단백질 결합; RNA 결합; 단백질 인산염 결합; ATP 바인딩;
셀룰러 컴포넌트	시토솔; 내피성 베시클 루멘; 소포체 망막 내강; 소포체 망막; 막으로 막다; 초점 접착; GO:0005578 세포외 행렬; 흑색성의; 플라즈마 막; 소포체성 망막 복합체; 세포외 지역; 중체의; 소포체성 망막; 세포질 과핵 지역; 세포외 외성체; 핵의; 단백질 함유 복합체; 콜라겐이 함유된 세포외 기질;
생물학적 과정	저산소증에 대한 반응; 스트레스에 대한 반응; 단백질 접이식 망막내막; 세포핵 과정에 대한 부정적인 규제; 수용체 매개 내포증; 소포체 망막 스트레스에 대한 반응; 유료 수신기 신호 경로; 인산단백질인인산화효소; ATF6 매개 확장 단백질 반응; 액틴 로드 조립체; 단백질 이동, ER에서 사이토솔로 역류; 칼슘 이온의 격리; 단백질 접이식; 유비쿼터스 의존적 OFT 경로; 단백질 수송; ATP에 대한 세포 반응; 생식 후 단백질 수정; 세포 단백질 대사 과정; 사이토카인 매개 신호 경로;
	출처:아미고 / 퀵고
직교체
	7184
	22027
	ENSG00000166598
	ENSMUSG00000020048
	P14625
	P08113
	NM_003299
	NM_011631
	NP_003290
	NP_035761
	위키다타
인간 보기/편집	마우스 보기/편집

열충격 단백질 90kDa 베타 멤버 1(HSP90B1)은 엔도플라스민, gp96, grp94 또는 ERP99로 알려져 있으며, 인간 내에서는 HSP90B1 유전자에 의해 암호화된 샤페론 단백질이다.^[5]^[6]

HSP90B1은 소포체 망막에서 발견되는 HSP90 파라로그다. 톨레와 같은 수용체나 통합체 같은 비밀 통로에서 단백질을 접는 데 결정적인 역할을 한다.^[7]^[8] 그것은 선천적 면역과 적응적 면역 모두를 조절하는 필수적인 면역 보호제로서 연루되어 왔다.^[9] 종양 유래 HSP90B1(vitespen)이 암 면역치료 임상시험에 들어갔다.^[10]^[11]^[12]^[13]

grp94는 녹내장, 다발성 골수종, 전이성 암 등 다발성 질환의 치료 대상인 것으로 나타났다. grp94는 1차 순서에 5개의 구별되는 아미노산을 포함하는데, 이 아미노산은 S1과 S2라는 2개의 고유한 하위 소매치기를 생성한다. 이들 하위포켓은 고객 단백질이 암세포에서 조절이 잘 되는 것처럼 보이기 때문에 보호포를 억제하기 위해 현재 연구에 활용되어 왔다.^[14]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000166598 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG00000020048 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maki RG, Old LJ, Srivastava PK (August 1990). "Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins". Proceedings of the National Academy of Sciences of the United States of America. 87 (15): 5658–62. doi:10.1073/pnas.87.15.5658. PMC 54386. PMID 2377606.
^ Chen B, Piel WH, Gui L, Bruford E, Monteiro A (December 2005). "The HSP90 family of genes in the human genome: insights into their divergence and evolution". Genomics. 86 (6): 627–37. doi:10.1016/j.ygeno.2005.08.012. PMID 16269234.
^ Randow F, Seed B (October 2001). "Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability". Nature Cell Biology. 3 (10): 891–6. doi:10.1038/ncb1001-891. PMID 11584270. S2CID 26559580.
^ Yang Y, Liu B, Dai J, Srivastava PK, Zammit DJ, Lefrançois L, Li Z (February 2007). "Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages". Immunity. 26 (2): 215–26. doi:10.1016/j.immuni.2006.12.005. PMC 2847270. PMID 17275357.,
^ Schild H, Rammensee HG (August 2000). "gp96--the immune system's Swiss army knife". Nature Immunology. 1 (2): 100–1. doi:10.1038/77770. PMID 11248798. S2CID 29571184.
^ Wood CG, Mulders P (August 2009). "Vitespen: a preclinical and clinical review". Future Oncology. 5 (6): 763–74. doi:10.2217/fon.09.46. PMID 19663726.
^ Tosti G, di Pietro A, Ferrucci PF, Testori A (November 2009). "HSPPC-96 vaccine in metastatic melanoma patients: from the state of the art to a possible future". Expert Review of Vaccines. 8 (11): 1513–26. doi:10.1586/erv.09.108. PMID 19863242. S2CID 207223461.
^ "NCT00293423". ClinicalTrials.gov, United States National Institutes of Health. Retrieved 2010-04-10. GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Recurrent or Progressive Glioma
^ Bloch O, Crane CA, Fuks Y, Kaur R, Aghi MK, Berger MS, Butowski NA, Chang SM, Clarke JL, McDermott MW, Prados MD, Sloan AE, Bruce JN, Parsa AT (January 2014). "Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial". Neuro-Oncology. 16 (2): 274–9. doi:10.1093/neuonc/not203. PMC 3895386. PMID 24335700.
^ Khandelwal A, Crowley VM, Blagg BS (October 2017). "Resorcinol-Based Grp94-Selective Inhibitors". ACS Medicinal Chemistry Letters. 8 (10): 1013–1018. doi:10.1021/acsmedchemlett.7b00193. PMC 5641966. PMID 29057043.

추가 읽기

Srivastava P (2001). "Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses". Annual Review of Immunology. 20 (1): 395–425. doi:10.1146/annurev.immunol.20.100301.064801. PMID 11861608.
Li Z, Dai J, Zheng H, Liu B, Caudill M (March 2002). "An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response". Frontiers in Bioscience. 7 (4): d731–51. doi:10.2741/A808. PMID 11861214.
Dollins DE, Warren JJ, Immormino RM, Gewirth DT (October 2007). "Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones". Molecular Cell. 28 (1): 41–56. doi:10.1016/j.molcel.2007.08.024. PMC 2094010. PMID 17936703.
Kaul SC, Taira K, Pereira-Smith OM, Wadhwa R (2003). "Mortalin: present and prospective". Experimental Gerontology. 37 (10–11): 1157–64. doi:10.1016/S0531-5565(02)00135-3. PMID 12470827. S2CID 44450296.
Schaiff WT, Hruska KA, McCourt DW, Green M, Schwartz BD (September 1992). "HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells". The Journal of Experimental Medicine. 176 (3): 657–66. doi:10.1084/jem.176.3.657. PMC 2119345. PMID 1512535.
Zolnierowicz S, Work C, Hutchison K, Fox IH (April 1990). "Partial separation of platelet and placental adenosine receptors from adenosine A2-like binding protein". Molecular Pharmacology. 37 (4): 554–9. PMID 2325637.
Hutchison KA, Nevins B, Perini F, Fox IH (May 1990). "Soluble and membrane-associated human low-affinity adenosine binding protein (adenotin): properties and homology with mammalian and avian stress proteins". Biochemistry. 29 (21): 5138–44. doi:10.1021/bi00473a020. PMID 2378869.
Chang SC, Erwin AE, Lee AS (May 1989). "Glucose-regulated protein (GRP94 and GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors". Molecular and Cellular Biology. 9 (5): 2153–62. doi:10.1128/mcb.9.5.2153. PMC 363009. PMID 2546060.
Anderson SL, Shen T, Lou J, Xing L, Blachere NE, Srivastava PK, Rubin BY (October 1994). "The endoplasmic reticular heat shock protein gp96 is transcriptionally upregulated in interferon-treated cells". The Journal of Experimental Medicine. 180 (4): 1565–9. doi:10.1084/jem.180.4.1565. PMC 2191700. PMID 7523574.
Bruneau N, Lombardo D (June 1995). "Chaperone function of a Grp 94-related protein for folding and transport of the pancreatic bile salt-dependent lipase". The Journal of Biological Chemistry. 270 (22): 13524–33. doi:10.1074/jbc.270.22.13524. PMID 7768954.
Chavany C, Mimnaugh E, Miller P, Bitton R, Nguyen P, Trepel J, Whitesell L, Schnur R, Moyer J, Neckers L (March 1996). "p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2". The Journal of Biological Chemistry. 271 (9): 4974–7. doi:10.1074/jbc.271.9.4974. PMID 8617772.
Kuznetsov G, Chen LB, Nigam SK (January 1997). "Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum". The Journal of Biological Chemistry. 272 (5): 3057–63. doi:10.1074/jbc.272.5.3057. PMID 9006956.
Hoshino T, Wang J, Devetten MP, Iwata N, Kajigaya S, Wise RJ, Liu JM, Youssoufian H (June 1998). "Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression". Blood. 91 (11): 4379–86. doi:10.1182/blood.v91.11.4379. PMID 9596688.
Linnik KM, Herscovitz H (August 1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". The Journal of Biological Chemistry. 273 (33): 21368–73. doi:10.1074/jbc.273.33.21368. PMID 9694898.
Delom F, Lejeune PJ, Vinet L, Carayon P, Mallet B (February 1999). "Involvement of oxidative reactions and extracellular protein chaperones in the rescue of misassembled thyroglobulin in the follicular lumen". Biochemical and Biophysical Research Communications. 255 (2): 438–43. doi:10.1006/bbrc.1999.0229. PMID 10049727.
Reddy RK, Lu J, Lee AS (October 1999). "The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis". The Journal of Biological Chemistry. 274 (40): 28476–83. doi:10.1074/jbc.274.40.28476. PMID 10497210.
Roher N, Sarno S, Miró F, Ruzzene M, Llorens F, Meggio F, Itarte E, Pinna LA, Plana M (September 2001). "The carboxy-terminal domain of Grp94 binds to protein kinase CK2 alpha but not to CK2 holoenzyme". FEBS Letters. 505 (1): 42–6. doi:10.1016/S0014-5793(01)02781-8. PMID 11557039. S2CID 52949128.
Vabulas RM, Braedel S, Hilf N, Singh-Jasuja H, Herter S, Ahmad-Nejad P, Kirschning CJ, Da Costa C, Rammensee HG, Wagner H, Schild H (June 2002). "The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway". The Journal of Biological Chemistry. 277 (23): 20847–53. doi:10.1074/jbc.M200425200. PMID 11912201.
Shin HJ, Kim SS, Cho YH, Lee SG, Rho HM (March 2002). "Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA". Archives of Virology. 147 (3): 471–91. doi:10.1007/s007050200001. PMID 11958450. S2CID 23653290.

12번 염색체의 유전자에 관한 이 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000166598 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG00000020048 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2377606-5] Maki RG, Old LJ, Srivastava PK (August 1990). "Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins". Proceedings of the National Academy of Sciences of the United States of America. 87 (15): 5658–62. doi:10.1073/pnas.87.15.5658. PMC 54386. PMID 2377606.

[pmid16269234-6] Chen B, Piel WH, Gui L, Bruford E, Monteiro A (December 2005). "The HSP90 family of genes in the human genome: insights into their divergence and evolution". Genomics. 86 (6): 627–37. doi:10.1016/j.ygeno.2005.08.012. PMID 16269234.

[pmid11584270-7] Randow F, Seed B (October 2001). "Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability". Nature Cell Biology. 3 (10): 891–6. doi:10.1038/ncb1001-891. PMID 11584270. S2CID 26559580.

[pmid17275357-8] Yang Y, Liu B, Dai J, Srivastava PK, Zammit DJ, Lefrançois L, Li Z (February 2007). "Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages". Immunity. 26 (2): 215–26. doi:10.1016/j.immuni.2006.12.005. PMC 2847270. PMID 17275357.,

[pmid11248798-9] Schild H, Rammensee HG (August 2000). "gp96--the immune system's Swiss army knife". Nature Immunology. 1 (2): 100–1. doi:10.1038/77770. PMID 11248798. S2CID 29571184.

[pmid19663726-10] Wood CG, Mulders P (August 2009). "Vitespen: a preclinical and clinical review". Future Oncology. 5 (6): 763–74. doi:10.2217/fon.09.46. PMID 19663726.

[pmid19863242-11] Tosti G, di Pietro A, Ferrucci PF, Testori A (November 2009). "HSPPC-96 vaccine in metastatic melanoma patients: from the state of the art to a possible future". Expert Review of Vaccines. 8 (11): 1513–26. doi:10.1586/erv.09.108. PMID 19863242. S2CID 207223461.

[NCT00293423_ClinicalTrials.gov-12] "NCT00293423". ClinicalTrials.gov, United States National Institutes of Health. Retrieved 2010-04-10. GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Recurrent or Progressive Glioma

[13] Bloch O, Crane CA, Fuks Y, Kaur R, Aghi MK, Berger MS, Butowski NA, Chang SM, Clarke JL, McDermott MW, Prados MD, Sloan AE, Bruce JN, Parsa AT (January 2014). "Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial". Neuro-Oncology. 16 (2): 274–9. doi:10.1093/neuonc/not203. PMC 3895386. PMID 24335700.

[14] Khandelwal A, Crowley VM, Blagg BS (October 2017). "Resorcinol-Based Grp94-Selective Inhibitors". ACS Medicinal Chemistry Letters. 8 (10): 1013–1018. doi:10.1021/acsmedchemlett.7b00193. PMC 5641966. PMID 29057043.

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HSP90B1

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