호모사피엔스 종의 단백질 코딩 유전자
Vacuolar 단백질 분류 관련 단백질 33B 는 인간에서 VPS33B 유전자 에 의해 인코딩되는 단백질 이다.[5] [6]
함수 Vesicle mediated 단백질 분류는 세포내 분자를 구별되는 유기체로 분리하는데 중요한 역할을 한다. 효모에 대한 유전학적 연구는 40개 이상의 VPS(Vacuolar 단백질 분류) 유전자를 밝혀냈다. 이 유전자는 1절 도메인 계열의 일원으로 효모 등급인 C Vps33 단백질과 동질인 랫드 Vps33b의 인간 직교체를 인코딩한다. 포유류 등급 C Vps 단백질은 주로 후기 내시경/라이소솜과 연관되어 있으며, 효모세포와 마찬가지로 내시경/라이소솜 경로에서 배실류 밀매 단계를 중재할 수 있다.[6]
모형 유기체 모델 유기체 는 VPS33B 기능의 연구에 사용되어 왔다.Wellcome Trust Sanger Institute 에서 조건부 Knockout 마우스 라인 Vps33b 가tm1a(EUCOMM)Wtsi 생성되었다.[7] 수컷과 암컷은 삭제 효과를 판단하기 위해 표준화된 표현식 화면 을[8] [9] [10] [11] [12] 수행된 추가 화면: 심층면역학적 표현법[13]
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