STX2

STX2
식별자
에일리어스	STX2, EPIM, EPM, STX2A, STX2B, STX2C, 구문in 2
외부 ID	OMIM: 132350 MGI: 108059 HomoloGene: 37559 GeneCard: STX2
유전자 위치(인간)
크르.	12번 염색체(인간)
끝.	130,839,266 bp
유전자 위치(마우스)
크르.	5번 염색체(쥐)
끝.	129,085,638 bp
RNA발현패턴
	상단 표시 위치:
	이차 난모세포; ; 상부 신경; ; 오른쪽 폐; ; 자궁내막간질세포; ; 신경절 융기; ; 위점막; ; 우측 자궁관; ; 기관지 상피 세포; ; 아킬레스건; ; 좌관상동맥;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 이량화 활성; SNAP 수용체 활성; 칼슘의존성 단백질결합; GO:0001948 단백질 결합; SNARE 바인딩;
셀룰러 컴포넌트	막의 적분 성분; 세포막내소기관; 막; 시냅스 소포; 혈장막; 기저측 혈장막; SNARE 콤플렉스; 라멜리포듐; 세포외 공간; 내막계; 시냅스 전막; 시냅스전활성대막;
생물학적 과정	세포 분화; 외배엽 발달; 시냅스 전 활성대막으로의 시냅스 소포 융합; 히드로페옥시드에 대한 반응; 아크로솜 반응; 베시클 도킹; 각질 외피 조립체; 단백질복합체올리고머화; 동물 기관 형태 형성; 세포내단백질; 소포체 수송; 신호 변환; 세포외부증; 소포 융합;
	출처:아미고 / QuickGO
맞춤법
	2054
	13852
	ENSG00000111450
	ENSMUSG000029428
	P32856
	Q00262
NM_001980; NM_194356; NM_001351049; NM_001351050; NM_001351051;
	NM_001351052
	NM_001286033; NM_001286034; NM_007941; NM_001359022
NP_001971; NP_919337; NP_001337978; NP_001337979; NP_001337980;
	NP_001337981
	없음
	위키데이터
인간 보기/편집	마우스 표시/편집

에피모르핀으로도 알려진 Syntaxin-2는 STX2 ^[5]^[6]^[7]유전자에 의해 인간에게 암호화되는 단백질이다.

이 유전자의 산물은 단백질의 신트랜신/에피몰핀 계열에 속한다.Syntaxins는 세포 내 수송 소포의 표적화 및 융합에 관여하는 큰 단백질 패밀리입니다.이 유전자의 산물은 상피-간질 상호작용과 상피세포 형태 형성 및 활성화를 조절한다.다른 아이소폼을 코드하는 대체적으로 스플라이스된 전사 변종이 ^[7]식별되었다.N 말단이 세포질 표면에 있을 때 세포 내 소포 도킹에 관여하는 t-SNARE로 작용하며 Syntaxin-2라고 불린다.뒤집어지면, 즉 N 말단은 세포외 표면에(일부 비고전적 분비 경로에 의해) 매달려 다용도 모르포겐으로 작용하며 에피몰핀이라고 불린다.이 막 단백질은 다양한 맥락에 따라 조절된 방식으로 상피 세포의 꼭대기 또는 기저부 표면 중 하나를 목표로 하는 또 다른 형태의 위상학적 대안을 이중으로 선택한다.간엽세포에 의해 발현되면 상피간엽계면에서 상피형태형성을 지시할 수 있다.

상호 작용

STX2는 SNAP-25,^[8]^[9] SNAP23,^[9]^[10]^[11]^[12] STXBP1^[8]^[13] 및 Syntaxin 결합 단백질 ^[13]3과 상호 작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG0000011450 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029428 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zha H, Remmers EF, Szpirer C, Szpirer J, Zhang H, Kozak CA, Wilder RL (Nov 1996). "The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12". Genomics. 37 (3): 386–9. doi:10.1006/geno.1996.0574. PMID 8938452.
^ Band AM, Kuismanen E (Jun 2005). "Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments". BMC Cell Biology. 6 (1): 26. doi:10.1186/1471-2121-6-26. PMC 1156879. PMID 15943887.
^ ^a ^b "Entrez Gene: STX2 syntaxin 2".
^ ^a ^b Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
^ ^a ^b Ravichandran V, Chawla A, Roche PA (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". The Journal of Biological Chemistry. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
^ Imai A, Nashida T, Yoshie S, Shimomura H (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives of Oral Biology. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
^ Li G, Alexander EA, Schwartz JH (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry. 278 (22): 19791–7. doi:10.1074/jbc.M212250200. PMID 12651853.
^ Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochemical and Biophysical Research Communications. 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. PMID 9168999.
^ ^a ^b Schraw TD, Lemons PP, Dean WL, Whiteheart SW (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.

추가 정보

Hirai Y, Takebe K, Takashina M, Kobayashi S, Takeichi M (May 1992). "Epimorphin: a mesenchymal protein essential for epithelial morphogenesis". Cell. 69 (3): 471–81. doi:10.1016/0092-8674(92)90448-L. PMID 1581962. S2CID 32814241.
Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (Jun 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877. S2CID 4265549.
Hirai Y (Mar 1993). "Molecular cloning of human epimorphin: identification of isoforms and their unique properties". Biochemical and Biophysical Research Communications. 191 (3): 1332–7. doi:10.1006/bbrc.1993.1363. PMID 8466509.
Oka Y, Hirai Y (Jan 1996). "Inductive influences of epimorphin on endothelial cells in vitro". Experimental Cell Research. 222 (1): 189–98. doi:10.1006/excr.1996.0024. PMID 8549663.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Betz A, Okamoto M, Benseler F, Brose N (Jan 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW, James DE (Mar 1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". The Journal of Biological Chemistry. 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Koshida S, Hirai Y (May 1997). "Identification of cellular recognition sequence of epimorphin and critical role of cell/epimorphin interaction in lung branching morphogenesis". Biochemical and Biophysical Research Communications. 234 (2): 522–5. doi:10.1006/bbrc.1997.6673. PMID 9177305.
Hirai Y, Lochter A, Galosy S, Koshida S, Niwa S, Bissell MJ (Jan 1998). "Epimorphin functions as a key morphoregulator for mammary epithelial cells". The Journal of Cell Biology. 140 (1): 159–69. doi:10.1083/jcb.140.1.159. PMC 2132590. PMID 9425164.
Thomas DM, Ferguson GD, Herschman HR, Elferink LA (Jul 1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Molecular Biology of the Cell. 10 (7): 2285–95. doi:10.1091/mbc.10.7.2285. PMC 25443. PMID 10397765.
Pabst S, Hazzard JW, Antonin W, Südhof TC, Jahn R, Rizo J, Fasshauer D (Jun 2000). "Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions". The Journal of Biological Chemistry. 275 (26): 19808–18. doi:10.1074/jbc.M002571200. PMID 10777504.
Kauppi M, Wohlfahrt G, Olkkonen VM (Nov 2002). "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3". The Journal of Biological Chemistry. 277 (46): 43973–9. doi:10.1074/jbc.M208315200. PMID 12198139.
Terasaki Y, Fukuda Y, Suga M, Ikeguchi N, Takeya M (2006). "Epimorphin expression in interstitial pneumonia". Respiratory Research. 6 (1): 6. doi:10.1186/1465-9921-6-6. PMC 548284. PMID 15651999.
Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T (Feb 2006). "Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity". Molecular Biology of the Cell. 17 (2): 977–89. doi:10.1091/mbc.E05-05-0462. PMC 1356605. PMID 16339081.

인간 염색체 12번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG0000011450 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000029428 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8938452-5] Zha H, Remmers EF, Szpirer C, Szpirer J, Zhang H, Kozak CA, Wilder RL (Nov 1996). "The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12". Genomics. 37 (3): 386–9. doi:10.1006/geno.1996.0574. PMID 8938452.

[pmid15943887-6] Band AM, Kuismanen E (Jun 2005). "Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments". BMC Cell Biology. 6 (1): 26. doi:10.1186/1471-2121-6-26. PMC 1156879. PMID 15943887.

[entrez-7] "Entrez Gene: STX2 syntaxin 2".

[pmid7768895-8] Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.

[pmid8663154-9] Ravichandran V, Chawla A, Roche PA (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". The Journal of Biological Chemistry. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.

[pmid12828989-10] Imai A, Nashida T, Yoshie S, Shimomura H (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives of Oral Biology. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.

[pmid12651853-11] Li G, Alexander EA, Schwartz JH (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry. 278 (22): 19791–7. doi:10.1074/jbc.M212250200. PMID 12651853.

[pmid9168999-12] Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochemical and Biophysical Research Communications. 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. PMID 9168999.

[pmid12773094-13] Schraw TD, Lemons PP, Dean WL, Whiteheart SW (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

Search

STX2

네임스페이스

더

상호 작용

레퍼런스

추가 정보