호모 사피엔스 종의 단백질 코드 유전자
만노스-6-인산수용체결합단백질1(M6PRBP1) 은 M6PRBP1 [5] 단백질 이다.유전자 자체뿐만 아니라 그것의 유전자 산물은 일반적으로 TIP47 로 알려져 있다.
기능. 만노스 6-인산 수용체(MPRS)는 리소좀 가수분해효소를 골지 로부터 엔도솜 으로 전달한 후 골지 복합체로 돌아간다.이 유전자에 의해 암호화된 단백질은 양이온 비의존 MPR과 양이온 의존 MPR의 세포질 도메인과 상호작용하며, 엔도솜에서 골지로의 운반에 필요하다. 이 단백질은 또한 RAS 종양 유전자군의 구성원인 GTPase RAB9(RAB9A )에 직접 결합한다. RAB9과의 상호작용은 [6]
M6PRBP1을 TIP47의 유전자 기호로 지정했음에도 불구하고 TIP47의 만노스-6-인산 수용체 결합 특성은 논란의 [7] TIP47 단백질은 과학 문헌에서 지질 [8]
TIP47은 페리필린 단백질군 에 속하며 페리필린과 아디포필린 을 포함 한 [9]
상호 작용 M6PRBP1은 만노스 6-인산 [10] [11] 나타났다 .
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