호모 사피엔스 종의 단백질 코드 유전자
AP-2 복합 서브유닛 시그마는 사람에게서 AP2S1 [5] [6] [7] 단백질 이다.
2개의 주요 클라트린 관련 어댑터 복합체 중 하나인 AP-2는 혈장막과 관련된 헤테로테트라머이다. 이 복합체는 두 개의 큰 체인, 중간 체인, 그리고 작은 체인으로 구성되어 있습니다. 이 유전자는 이 복합체의 작은 사슬을 암호화한다. 이 유전자에서 대체 스플라이싱이 관찰되었으며 두 개의 알려진 [7]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000042753 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000008036 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3". Cytogenet Cell Genet . 75 (2–3): 132–5. doi :10.1159/000134463 . PMID 9040778 . ^ Holzmann K, Poltl A, Sauermann G (Nov 1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene . 220 (1–2): 39–44. doi :10.1016/S0378-1119(98)00406-5 . PMID 9767099 . ^ a b "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit" . 추가 정보 Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat construction in endocytosis". Curr. Opin. Struct. Biol . 10 (2): 220–8. doi :10.1016/S0959-440X(00)00071-3 . PMID 10753805 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . Byland R, Vance PJ, Hoxie JA, Marsh M (2007). "A Conserved Dileucine Motif Mediates Clathrin and AP-2–dependent Endocytosis of the HIV-1 Envelope Protein" . Mol. Biol. Cell . 18 (2): 414–25. doi :10.1091/mbc.E06-06-0535 . PMC 1783771 PMID 17108326 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Batonick M, Favre M, Boge M, et al. (2006). "Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2" . Virology . 342 (2): 190–200. doi :10.1016/j.virol.2005.08.001 PMID 16139856 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Vendeville A, Rayne F, Bonhoure A, et al. (2005). "HIV-1 Tat Enters T Cells Using Coated Pits before Translocating from Acidified Endosomes and Eliciting Biological Responses" . Mol. Biol. Cell . 15 (5): 2347–60. doi :10.1091/mbc.E03-12-0921 . PMC 404028 PMID 15020715 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Collins BM, McCoy AJ, Kent HM, et al. (2002). "Molecular architecture and functional model of the endocytic AP2 complex" . Cell . 109 (4): 523–35. doi :10.1016/S0092-8674(02)00735-3 PMID 12086608 . S2CID 483953 . Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins" . J. Virol . 73 (2): 1350–61. doi :10.1128/JVI.73.2.1350-1361.1999 . PMC 103959 PMID 9882340 . Kirchhausen T, Nathanson KL, Matsui W, et al. (1989). "Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2" . Proc. Natl. Acad. Sci. U.S.A . 86 (8): 2612–6. doi :10.1073/pnas.86.8.2612 PMC 286967 PMID 2495531 . Kirchhausen T, Davis AC, Frucht S, et al. (1991). "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast" . J. Biol. Chem . 266 (17): 11153–7. doi :10.1016/S0021-9258(18)99141-6 PMID 2040623 .
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