호모 사피엔스 종의 단백질 코드 유전자
AP-1 복합 서브유닛 베타-1 은 사람 에게서 AP1B1 유전자에 [5] [6] [7] 단백질 이다.
어댑터 단백질 복합체 1은 골지 복합체에 위치한 피복 소포의 세포질 표면에서 발견되며, 막에 대한 클라트린의 모집과 막 통과 수용체의 세포질 꼬리 내의 선별 신호 인식을 매개한다. 이 복합체는 두 개의 큰 배지 서브유닛과 하나의 작은 아답틴 서브유닛으로 구성된 헤테로테트라머이다. 이 유전자에 의해 코드된 단백질은 이 복합체의 큰 소단위 중 하나로 작용하며 적응단백질군의 구성원이다. 이 유전자는 뇌수막종 후보 유전자이다. 이 유전자에 대해 서로 다른 아이소폼을 코드하는 2개의 전사 변이가 발견되었으며, 대체 폴리아데닐화 신호를 이용한 변이가 존재한다.[7]
상호 작용 AP1B1은 KIF13A [8] AP1G1 과 [9] [10] [11] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000100280 - 앙상블 , 2017년 5월^ a b c GRCm38 : Ensembl 릴리즈 89 : ENSMUSG00000009090 - Ensembl , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP (January 1995). "Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene". Hum Mol Genet . 3 (8): 1393–9. doi :10.1093/hmg/3.8.1393 . PMID 7987321 . ^ Peyrard M, Pan HQ, Kedra D, Fransson I, Swahn S, Hartman K, Clifton SW, Roe BA, Dumanski JP (February 1997). "Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12". Genomics . 36 (1): 112–7. doi :10.1006/geno.1996.0431 . PMID 8812422 . ^ a b "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit" .^ Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; Takio K; Hirokawa N (November 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex" . Cell . UNITED STATES. 103 (4): 569–81. doi :10.1016/S0092-8674(00)00161-6 ISSN 0092-8674 . PMID 11106728 . ^ Takatsu, H; Sakurai M; Shin H W; Murakami K; Nakayama K (September 1998). "Identification and characterization of novel clathrin adaptor-related proteins" . J. Biol. Chem . UNITED STATES. 273 (38): 24693–700. doi :10.1074/jbc.273.38.24693 ISSN 0021-9258 . PMID 9733768 . ^ Fölsch, H; Ohno H; Bonifacino J S; Mellman I (October 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells" . Cell . UNITED STATES. 99 (2): 189–98. doi :10.1016/S0092-8674(00)81650-5 ISSN 0092-8674 . PMID 10535737 . ^
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