호모 사피엔스 종의 단백질 코드 유전자
AP-1 복합 서브유닛 감마 라이크 2는 사람에게서 AP1G2 [5] [6] [7] 단백질 이다.
아답틴은 플라즈마막 또는 골지 횡단 네트워크에서 리소좀으로 리간드 수용체 복합체를 운반하는 클라트린 코팅 소포의 중요한 구성요소이다. 단백질의 아답틴 계열은 알파, 베타, 베타 프라임, 감마 아답틴이라는 네 가지 종류의 분자로 구성되어 있다. 아답틴은 중간 및 작은 서브유닛과 함께 어댑터라고 불리는 헤테로전자 복합체를 형성하는데, 그 역할은 클래트린 코팅된 피트 및 소포의 형성을 촉진하는 것입니다. 이 유전자에 의해 코드된 단백질은 감마 적응 단백질이며 어댑터 복합체 소단위군에 속한다. 복합체와 함께 이 단백질은 골기 통과 네트워크와 세포 표면 사이의 복잡한 경로의 어떤 교통 단계에서 기능하는 것으로 생각된다. 동일한 단백질을 [7]
상호 작용 AP1G2는 NEDD4 와 [8] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000213983 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000040701 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Oct 1998). "Identification and characterization of novel clathrin adaptor-related proteins" . J Biol Chem . 273 (38): 24693–700. doi :10.1074/jbc.273.38.24693 PMID 9733768 . ^ Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I (Oct 1998). "Cloning, expression, and localization of a novel gamma-adaptin-like molecule". FEBS Lett . 435 (2–3): 263–8. doi :10.1016/S0014-5793(98)01083-7 . PMID 9762922 . S2CID 83518205 . ^ a b "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit" .^ Rost, Martina; Döring Tatjana; Prange Reinhild (Nov 2008). "gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway" . J. Biol. Chem . United States. 283 (46): 32119–30. doi :10.1074/jbc.M802632200 ISSN 0021-9258 . PMID 18772139 .
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