호모 사피엔스 종의 단백질 코드 유전자
AP-4 복합 서브유닛 베타-1 은 사람에게서 AP4B1 [5] [6] 단백질 이다.
기능. 헤테로전자 어댑터 단백질(AP) 복합체는 세포내 및 분비 경로의 다양한 단계에서 일체형 막 단백질을 분류합니다. AP4는 베타-4(AP4B1, 이 단백질)와 엡실론-4(AP4E1 )의 2개의 큰 사슬, mu-4(AP4M1 )와 작은 사슬인 시그마-4(AP4S1 )[6]
상호 작용 AP4B1은 AP4M1 과 [7] 것 으로 나타났습니다.
임상 관련성 AP4 복합 매개 인신매매는 뇌의 발달과 [8] [9]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000134262 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000032952 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Dell'Angelica EC, Mullins C, Bonifacino JS (Apr 1999). "AP-4, a novel protein complex related to clathrin adaptors" . J Biol Chem . 274 (11): 7278–85. doi :10.1074/jbc.274.11.7278 PMID 10066790 . ^ a b "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit" .^ Hirst J, Bright NA, Rous B, Robinson MS (August 1999). "Characterization of a fourth adaptor-related protein complex" . Mol. Biol. Cell . 10 (8): 2787–802. doi :10.1091/mbc.10.8.2787 . PMC 25515 PMID 10436028 . ^ Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck G, Ekici A, Brockschmidt FF, Nöthen MM, Munnich A, Strom TM, Reis A, Colleaux L (June 2011). "Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature" . Am. J. Hum. Genet . 88 (6): 788–95. doi :10.1016/j.ajhg.2011.04.019 . PMC 3113253 PMID 21620353 . ^ "Cerebral Palsy Linked to Genetic Abnormalities" . medscape.
외부 링크 UCSC Genome Browser의 인간 위치 PDBe-KB 는 PDB for Human AP-4 complex subunit beta-1에서 사용 가능한 모든 구조 정보의 개요를 제공합니다.추가 정보 Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex" . Mol. Biol. Cell . 10 (8): 2787–802. doi :10.1091/mbc.10.8.2787 . PMC 25515 PMID 10436028 . Takatsu H, Futatsumori M, Yoshino K, et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochem. Biophys. Res. Commun . 284 (4): 1083–9. doi :10.1006/bbrc.2001.5081 . PMID 11409905 . Cayrol C, Cougoule C, Wright M (2003). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1". Biochem. Biophys. Res. Commun . 298 (5): 720–30. doi :10.1016/S0006-291X(02)02522-6 . PMID 12419313 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . 
