나트륨-수소 역추진체 1
Sodium–hydrogen antiporter 1
나트륨/수소 교환기 1(NHE-1) 또는 SLC9A1(SoLute Carrier 9A1)로 알려진 나트륨-수소 대항체 1(NHE-1)은 사람에게 SLC9A1 [5]유전자에 의해 암호화되는 나트륨-수소 대항체의 등형식이다.
기능.
Na/H+ 역호터(SLC9A1)는+ 척추동물 세포의 부피 및 pH 조절에 관여하는 유비쿼터스 막 결합 효소이다.비특이성 이뇨제 아밀로라이드에 의해 억제되며 성장인자, 유사원, 신경전달물질, 종양촉진제 [6]등을 포함한 다양한 신호에 의해 활성화된다.
상호 작용
나트륨-수소 대항체 1은 탄산 무수분해효소[7] II 및 [8][9][10]CHP와 상호작용하는 것으로 나타났다.또한 Duchenne 근디스트로피 [11]치료를 위해 개발되고 있는 실험 약물인 리메포라이드의 대상이다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000090020 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000028854 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (August 1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Molecular and Cellular Biochemistry. 125 (2): 137–43. doi:10.1007/BF00936442. PMID 8283968. S2CID 24360200.
- ^ Cardone RA, Alfarouk KO, Elliott RL, Alqahtani SS, Ahmed SB, Aljarbou AN, et al. (July 2019). "The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela". International Journal of Molecular Sciences. 20 (15): 3694. doi:10.3390/ijms20153694. PMC 6696090. PMID 31357694.
- ^ Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L (September 2002). "Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger". The Journal of Biological Chemistry. 277 (39): 36085–91. doi:10.1074/jbc.M111952200. PMID 12138085.
- ^ Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (February 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biological & Pharmaceutical Bulletin. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
- ^ Lin X, Barber DL (October 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12631–6. Bibcode:1996PNAS...9312631L. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
- ^ Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
- ^ Spreitzer, Helmut (26 May 2015). "Rimeporide". Österreichische Apothekerzeitung (in German). 69 (11): 12.
추가 정보
- Yu L, Quinn DA, Garg HG, Hales CA (June 2008). "Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling". American Journal of Respiratory and Critical Care Medicine. 177 (11): 1276–84. doi:10.1164/rccm.200710-1522OC. PMC 2408441. PMID 18310478.
- Rios EJ, Fallon M, Wang J, Shimoda LA (November 2005). "Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells". American Journal of Physiology. Lung Cellular and Molecular Physiology. 289 (5): L867–74. doi:10.1152/ajplung.00455.2004. PMID 15964895.
- Cingolani HE, Ennis IL (March 2007). "Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy". Circulation. 115 (9): 1090–100. doi:10.1161/CIRCULATIONAHA.106.626929. PMID 17339567.
- Meima ME, Mackley JR, Barber DL (July 2007). "Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1". Current Opinion in Nephrology and Hypertension. 16 (4): 365–72. doi:10.1097/MNH.0b013e3281bd888d. PMID 17565280. S2CID 25616109.
- Tse CM, Ma AI, Yang VW, Watson AJ, Levine S, Montrose MH, et al. (August 1991). "Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger". The EMBO Journal. 10 (8): 1957–67. doi:10.1002/j.1460-2075.1991.tb07725.x. PMC 452875. PMID 1712287.
- Dudley CR, Giuffra LA, Tippett P, Kidd KK, Reeders ST (November 1990). "The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1". Human Genetics. 86 (1): 79–83. doi:10.1007/bf00205179. PMID 1979310. S2CID 20107780.
- Sardet C, Counillon L, Franchi A, Pouysségur J (February 1990). "Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD". Science. 247 (4943): 723–6. Bibcode:1990Sci...247..723S. doi:10.1126/science.2154036. PMID 2154036.
- Sardet C, Franchi A, Pouysségur J (January 1989). "Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter". Cell. 56 (2): 271–80. doi:10.1016/0092-8674(89)90901-X. PMID 2536298. S2CID 2782563.
- Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenetics and Cell Genetics. 48 (1): 6–8. doi:10.1159/000132575. PMID 2846238.
- Counillon L, Pouysségur J, Reithmeier RA (August 1994). "The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain". Biochemistry. 33 (34): 10463–9. doi:10.1021/bi00200a030. PMID 8068684.
- Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (August 1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Molecular and Cellular Biochemistry. 125 (2): 137–43. doi:10.1007/BF00936442. PMID 8283968. S2CID 24360200.
- Lin X, Barber DL (October 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12631–6. Bibcode:1996PNAS...9312631L. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
- Shrode LD, Gan BS, D'Souza SJ, Orlowski J, Grinstein S (August 1998). "Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage". The American Journal of Physiology. 275 (2): C431-9. doi:10.1152/ajpcell.1998.275.2.C431. PMID 9688597.
- Wakabayashi S, Pang T, Su X, Shigekawa M (March 2000). "A novel topology model of the human Na(+)/H(+) exchanger isoform 1". The Journal of Biological Chemistry. 275 (11): 7942–9. doi:10.1074/jbc.275.11.7942. PMID 10713111.
- Garden OA, Musk P, Worthington-White DA, Dewey MJ, Rich IN (July 2000). "Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: A comparison with healthy controls". Cancer Genetics and Cytogenetics. 120 (1): 37–43. doi:10.1016/S0165-4608(99)00246-0. PMID 10913675.
- Denker SP, Huang DC, Orlowski J, Furthmayr H, Barber DL (December 2000). "Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation". Molecular Cell. 6 (6): 1425–36. doi:10.1016/S1097-2765(00)00139-8. PMID 11163215.
- Lehoux S, Florian JA, Berk BC (May 2001). "14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange". The Journal of Biological Chemistry. 276 (19): 15794–800. doi:10.1074/jbc.M100410200. PMID 11279064.
- Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
- Yan W, Nehrke K, Choi J, Barber DL (August 2001). "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor". The Journal of Biological Chemistry. 276 (33): 31349–56. doi:10.1074/jbc.M102679200. PMID 11369779.
- Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, et al. (November 2001). "Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization". Molecular and Cellular Biology. 21 (22): 7545–57. doi:10.1128/MCB.21.22.7545-7557.2001. PMC 99926. PMID 11604491.
- Mailänder J, Müller-Esterl W, Dedio J (November 2001). "Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1". FEBS Letters. 507 (3): 331–5. doi:10.1016/S0014-5793(01)02986-6. PMID 11696366.
- Shen MR, Wilkins RJ, Chou CY, Ellory JC (February 2002). "Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells". FEBS Letters. 512 (1–3): 52–8. doi:10.1016/S0014-5793(01)03317-8. PMID 11852051.
- Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, et al. (December 2002). "NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging". The Journal of Biological Chemistry. 277 (49): 47399–406. doi:10.1074/jbc.M204759200. PMID 12221084.
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