탄산화 무수화효소 II
Carbonic anhydrase II탄산 무수 효소 II(gene name CA2)는 인간 α 탄산화 무수제의 16가지 형태 중 하나이다.[5]탄산 무수효소는 이산화탄소의 가역성 수화를 촉진한다.이 효소의 결함은 골관산화와 신관산화와 관련이 있다.신탄산 무수효소는 근위부 관에 있는 중탄산염 이온을 재흡수할 수 있다.[6] 뼈의 탄산 무수분해효소 활동이 상실되면 골수체의 재흡수 촉진 능력이 저하되어 골수화증(골수화증)[7]이 발생한다.
상호작용
탄산 무수화효소 II는 밴드[8][9][10][11] 3 및 나트륨-수소 항정신병자 1과 상호작용하는 것으로 나타났다.[12]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000104267 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000027562 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ 프로스트, S, & McKenna, R. (2014)탄산 무수화효소 : 메커니즘, 규제, 질병과의 연계, 산업적 응용(하위 세포 생화학)도드레흐트: 스프링거. 도이:10.1007/978-94-007-7359-2
- ^ "Entrez Gene: CA2 carbonic anhydrase II".
- ^ Reference, Genetics Home. "Osteopetrosis". Genetics Home Reference. Retrieved 2018-10-31.
- ^ Sterling, D; Reithmeier R A; Casey J R (December 2001). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers". J. Biol. Chem. United States. 276 (51): 47886–94. doi:10.1074/jbc.M105959200. ISSN 0021-9258. PMID 11606574.
- ^ Vince, J W; Reithmeier R A (October 1998). "Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte C1-/HCO3- exchanger". J. Biol. Chem. UNITED STATES. 273 (43): 28430–7. doi:10.1074/jbc.273.43.28430. ISSN 0021-9258. PMID 9774471.
- ^ Vince, J W; Carlsson U; Reithmeier R A (November 2000). "Localization of the Cl-/HCO3- anion exchanger binding site to the amino-terminal region of carbonic anhydrase II". Biochemistry. UNITED STATES. 39 (44): 13344–9. doi:10.1021/bi0015111. ISSN 0006-2960. PMID 11063570.
- ^ Vince, J W; Reithmeier R A (May 2000). "Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1". Biochemistry. UNITED STATES. 39 (18): 5527–33. doi:10.1021/bi992564p. ISSN 0006-2960. PMID 10820026.
- ^ Li, Xiuju; Alvarez Bernardo; Casey Joseph R; Reithmeier Reinhart A F; Fliegel Larry (September 2002). "Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger". J. Biol. Chem. United States. 277 (39): 36085–91. doi:10.1074/jbc.M111952200. ISSN 0021-9258. PMID 12138085.
추가 읽기
- Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64 (1): 375–401. doi:10.1146/annurev.bi.64.070195.002111. PMID 7574487.
- Kumpulainen T (1979). "Immunohistochemical localization of human carbonic anhydrase isoenzyme C.". Histochemistry. 62 (3): 271–80. doi:10.1007/BF00508355. PMID 114507. S2CID 21606492.
- Henderson LE, Henriksson D, Nyman PO (1976). "Primary structure of human carbonic anhydrase C." J. Biol. Chem. 251 (18): 5457–63. doi:10.1016/S0021-9258(17)33081-8. PMID 823150.
- Hu PY, Roth DE, Skaggs LA, et al. (1993). "A splice junction mutation in intron 2 of the carbonic anhydrase II gene of osteopetrosis patients from Arabic countries". Hum. Mutat. 1 (4): 288–92. doi:10.1002/humu.1380010404. PMID 1301935. S2CID 28188859.
- Roth DE, Venta PJ, Tashian RE, Sly WS (1992). "Molecular basis of human carbonic anhydrase II deficiency". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1804–8. Bibcode:1992PNAS...89.1804R. doi:10.1073/pnas.89.5.1804. PMC 48541. PMID 1542674.
- Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
- Schwartz GJ, Brion LP, Corey HE, Dorfman HD (1991). "Case report 668. Carbonic anhydrase II deficiency syndrome (osteopetrosis associated with renal tubular acidosis and cerebral calcification)". Skeletal Radiol. 20 (6): 447–52. doi:10.1007/BF00191090. PMID 1925679. S2CID 29176430.
- Venta PJ, Welty RJ, Johnson TM, et al. (1991). "Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His----Tyr): complete structure of the normal human CA II gene". Am. J. Hum. Genet. 49 (5): 1082–90. PMC 1683243. PMID 1928091.
- Venta PJ, Tashian RE (1990). "PCR detection of the TAQ1 polymorphism at the CA2 locus". Nucleic Acids Res. 18 (18): 5585. doi:10.1093/nar/18.18.5585. PMC 332284. PMID 1977133.
- Sato S, Zhu XL, Sly WS (1990). "Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient patients". Proc. Natl. Acad. Sci. U.S.A. 87 (16): 6073–6. Bibcode:1990PNAS...87.6073S. doi:10.1073/pnas.87.16.6073. PMC 54474. PMID 2117271.
- Kaunisto K, Parkkila S, Tammela T, et al. (1990). "Immunohistochemical localization of carbonic anhydrase isoenzymes in the human male reproductive tract". Histochemistry. 94 (4): 381–6. doi:10.1007/BF00266444. PMID 2121671. S2CID 22668787.
- Backman U, Danielsson B, Wistrand PJ (1991). "The excretion of carbonic anhydrase isozymes CA I and CA II in the urine of apparently healthy subjects and in patients with kidney disease". Scand. J. Clin. Lab. Invest. 50 (6): 627–33. doi:10.3109/00365519009089180. PMID 2123360.
- Forsman C, Behravan G, Osterman A, Jonsson BH (1989). "Production of active human carbonic anhydrase II in E. coli". Acta Chemica Scandinavica B. 42 (5): 314–8. doi:10.3891/acta.chem.scand.42b-0314. PMID 2850697.
- Venta PJ, Montgomery JC, Hewett-Emmett D, Tashian RE (1986). "Comparison of the 5' regions of human and mouse carbonic anhydrase II genes and identification of possible regulatory elements" (PDF). Biochim. Biophys. Acta. 826 (4): 195–201. doi:10.1016/0167-4781(85)90006-5. hdl:2027.42/25466. PMID 3000449.
- Ohlsson A, Cumming WA, Paul A, Sly WS (1986). "Carbonic anhydrase II deficiency syndrome: recessive osteopetrosis with renal tubular acidosis and cerebral calcification". Pediatrics. 77 (3): 371–81. PMID 3081869.
- Nakai H, Byers MG, Venta PJ, et al. (1987). "The gene for human carbonic anhydrase II (CA2) is located at chromosome 8q22". Cytogenet. Cell Genet. 44 (4): 234–5. doi:10.1159/000132378. PMID 3107918.
- Montgomery JC, Venta PJ, Tashian RE, Hewett-Emmett D (1987). "Nucleotide sequence of human liver carbonic anhydrase II cDNA". Nucleic Acids Res. 15 (11): 4687. doi:10.1093/nar/15.11.4687. PMC 340889. PMID 3108857.
- Murakami H, Marelich GP, Grubb JH, et al. (1988). "Cloning, expression, and sequence homologies of cDNA for human carbonic anhydrase II". Genomics. 1 (2): 159–66. doi:10.1016/0888-7543(87)90008-5. PMID 3121496.
- Eriksson AE, Jones TA, Liljas A (1989). "Refined structure of human carbonic anhydrase II at 2.0 A resolution". Proteins. 4 (4): 274–82. doi:10.1002/prot.340040406. PMID 3151019. S2CID 25590322.
- Eriksson AE, Kylsten PM, Jones TA, Liljas A (1989). "Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN- ion to the zinc at high pH". Proteins. 4 (4): 283–93. doi:10.1002/prot.340040407. PMID 3151020. S2CID 25849532.