PD-102,807

PD-102,807
PD-102,807
PD102807 structure.png
식별자
  • 에틸3,6a,11,14-테트라히드로-9-메톡시-2-메틸-(12H)-이소퀴노[1,2-b]피롤로[3,2-f][1,3]벤조옥사진-1-카르복실레이트
CAS 번호
PubChem CID
켐스파이더
유니
첸블
CompTox 대시보드 (EPA )
화학 및 물리 데이터
공식C23H24N2O4
몰 질량392.455 g/g−1/g
3D 모델(JSmol)
  • CCOC(=O)c1c(C)[nH]c(c1c3C5)cc3OC2N5CC4c2cc(OC)c4
  • InChI=1S/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-17(21)12-25-10-9-14-15(27)5-6-16(14)2225-19/29,8-5h
  • 키: VDDUJINYXKGZLV-UHFFFAOYSA-N checkY
☒NcheckY (이게 뭐죠?) (표준)

PD-102,807은 무스카린성 아세틸콜린 수용체4 [1][2][3]M의 선택적 길항제 역할을 하는 약물이다.그것은 신체와 [4][5][6][7]뇌에서 서로 다른 무스카린 수용체 아형의 영향을 연구하기 위해 과학 연구에 사용된다.

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레퍼런스

  1. ^ Olianas MC, Onali P (1999). "PD 102807, a novel muscarinic M4 receptor antagonist, discriminates between striatal and cortical muscarinic receptors coupled to cyclic AMP". Life Sciences. 65 (21): 2233–40. doi:10.1016/S0024-3205(99)00488-9. PMID 10576595.
  2. ^ Varoli L, Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Bedini A, Fazio N, Spampinato S (May 2008). "Diphenidol-related diamines as novel muscarinic M4 receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 18 (9): 2972–6. doi:10.1016/j.bmcl.2008.03.061. PMID 18395442.
  3. ^ Böhme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD (July 2002). "Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors". Journal of Medicinal Chemistry. 45 (14): 3094–102. doi:10.1021/jm011116o. PMID 12086495.
  4. ^ Pujol Lereis VA, Hita FJ, Gobbi MD, Verdi MG, Rodriguez MC, Rothlin RP (March 2006). "Pharmacological characterization of muscarinic receptor subtypes mediating vasoconstriction of human umbilical vein". British Journal of Pharmacology. 147 (5): 516–23. doi:10.1038/sj.bjp.0706654. PMC 1616972. PMID 16444291.
  5. ^ Hogan K, Markos F (February 2007). "Muscarinic type 1 receptors mediate part of nitric oxide's vagal facilitatory effect in the isolated innervated rat right atrium". Nitric Oxide: Biology and Chemistry. 16 (1): 110–7. doi:10.1016/j.niox.2006.05.005. PMID 16843016.
  6. ^ Myslivecek J, Klein M, Novakova M, Ricny J (July 2008). "The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles". Naunyn-Schmiedeberg's Archives of Pharmacology. 378 (1): 103–16. doi:10.1007/s00210-008-0285-8. PMID 18443764.
  7. ^ Lau BK, Vaughan CW (November 2008). "Muscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal gray". Molecular Pharmacology. 74 (5): 1392–8. doi:10.1124/mol.108.045872. PMID 18678620.