나트륨-수소 역추진기 3 조절기 1

Sodium-hydrogen antiporter 3 regulator 1
SLC9A3R1
Protein SLC9A3R1 PDB 1g9o.png
사용 가능한 구조
PDBOrtholog 검색: PDBe RCSB
식별자
에일리어스SLC9A3R1, EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2, 나트륨수소대향기3조절기1, SLC9A3조절기1
외부 IDOMIM: 604990 MGI: 1349482 HomoloGene: 3137 GeneCard: SLC9A3R1
맞춤법
종.인간마우스
엔트레즈

9368

26941

앙상블

ENSG00000109062

ENSMUSG000020733

유니프로트

O14745

P70441

RefSeq(mRNA)

NM_004252

NM_012030

RefSeq(단백질)

NP_004243

NP_036160

장소(UCSC)Chr 17: 74.75 ~74.77 MbChr 11: 115.05 ~115.07 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

나트륨-수소 안티포터 3 조절기 1은 나트륨-수소 안티포터 3의 조절기이다.SLC9A3R1 유전자에 의해 암호화된다.ERM 결합 단백질 50(EBP50) 또는 Na+/H+ 교환기 규제 계수(NHERF1)라고도 합니다.그것은 상당한 단백질 역학을 수반하는 장거리 알로스테리를 통해 상호작용하는 것으로 여겨진다[5].

메커니즘

에즈린(VIL2; MIM 123900)-라디신(RDX; MIM 179410)-모에신(MSN; MIM 309845)(ERM) 단백질 패밀리의 구성원은 편광상피세포의 원단면에 고농축되어 있다.이 세포들은 액틴 필라멘트의 다발을 포함하는 마이크로빌리로 박혀 있는데, 마이크로빌리를 조립하고 유지하기 위해 막에 부착해야 합니다.ERM 단백질은 NF2(MIM 607379) 유전자 생성물인 멀린과 함께 일체형 막과 세포골격 단백질 사이의 링커로 생각되며 체외에서 직접 작용에 결합한다.액틴 세포골격 재구성을 위해서는 나트륨/수소 교환기(SLC9A3, MIM 182307)의 활성화가 필요하다.SLC9A3R1은 ERM결합단백질이다.[OMIM [6]제공]

상호 작용

나트륨-수소 대향기 3 조절기 1은 다음과 상호작용하는 것으로 나타났다.

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레퍼런스

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