라디신
Radixin
Radixin은 RDX [5][6][7]유전자에 의해 인간에게 암호화되는 단백질이다.
라딕신은 세포골격 단백질로 액틴과 혈장막을 연결하는 데 중요할 수 있다.그것은 에즈린과 모신 둘 다와 순서적으로 매우 유사하다.라딕신 유전자는 11q23까지 형광체 교잡에 의해 국소화 되었다.의사유전자(RDXP2)를 나타내는 잘린 버전이 Xp21.3에 할당되었습니다.인트론(RDXP1)이 부족한 것으로 보이는 또 다른 유사 유전자는 Southern 및 PCR [7]분석에 의해 11p로 매핑되었다.
상호 작용
Radixin은 GNA13과 상호작용하는 것으로 나타났다.[8]
「 」를 참조해 주세요.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000137710 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000032050 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wilgenbus KK, Milatovich A, Francke U, Furthmayr H (June 1993). "Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes". Genomics. 16 (1): 199–206. doi:10.1006/geno.1993.1159. PMID 8486357.
- ^ Khan SY, Ahmed ZM, Shabbir MI, Kitajiri S, Kalsoom S, Tasneem S, Shayiq S, Ramesh A, Srisailpathy S, Khan SN, Smith RJ, Riazuddin S, Friedman TB, Riazuddin S (April 2007). "Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus". Hum Mutat. 28 (5): 417–23. doi:10.1002/humu.20469. PMID 17226784. S2CID 7671031.
- ^ a b "Entrez Gene: RDX radixin".
- ^ Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (August 2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
추가 정보
- Hoeflich KP, Ikura M (2005). "Radixin: cytoskeletal adopter and signaling protein". Int. J. Biochem. Cell Biol. 36 (11): 2131–6. doi:10.1016/j.biocel.2003.11.018. PMID 15313460.
- Matarrese P, Malorni W (2006). "Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death". Cell Death Differ. 12 Suppl 1: 932–41. doi:10.1038/sj.cdd.4401582. PMID 15818415.
- Sato N, Funayama N, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S (1992). "A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites". J. Cell Sci. 103 (1): 131–43. PMID 1429901.
- Hirao M, Sato N, Kondo T, Yonemura S, Monden M, Sasaki T, Takai Y, Tsukita S, Tsukita S (1996). "Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway". J. Cell Biol. 135 (1): 37–51. doi:10.1083/jcb.135.1.37. PMC 2121020. PMID 8858161.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Stemmer-Rachamimov AO, Gonzalez-Agosti C, Xu L, Burwick JA, Beauchamp R, Pinney D, Louis DN, Ramesh V (1997). "Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system". J. Neuropathol. Exp. Neurol. 56 (6): 735–42. doi:10.1097/00005072-199756060-00011. PMID 9184664.
- Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y (1997). "Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein". J. Biol. Chem. 272 (37): 23371–5. doi:10.1074/jbc.272.37.23371. PMID 9287351.
- Kondo T, Takeuchi K, Doi Y, Yonemura S, Nagata S, Tsukita S (1997). "ERM (Ezrin/Radixin/Moesin)-based Molecular Mechanism of Microvillar Breakdown at an Early Stage of Apoptosis". J. Cell Biol. 139 (3): 749–58. doi:10.1083/jcb.139.3.749. PMC 2141718. PMID 9348291.
- Murthy A, Gonzalez-Agosti C, Cordero E, Pinney D, Candia C, Solomon F, Gusella J, Ramesh V (1998). "NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins". J. Biol. Chem. 273 (3): 1273–6. doi:10.1074/jbc.273.3.1273. PMID 9430655.
- Matsui T, Maeda M, Doi Y, Yonemura S, Amano M, Kaibuchi K, Tsukita S, Tsukita S (1998). "Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association". J. Cell Biol. 140 (3): 647–57. doi:10.1083/jcb.140.3.647. PMC 2140160. PMID 9456324.
- Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (1998). "Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2". J. Cell Biol. 140 (4): 885–95. doi:10.1083/jcb.140.4.885. PMC 2141743. PMID 9472040.
- Bhartur SG, Goldenring JR (1998). "Mapping of ezrin dimerization using yeast two-hybrid screening". Biochem. Biophys. Res. Commun. 243 (3): 874–7. doi:10.1006/bbrc.1998.8196. PMID 9501018.
- Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H, Nakano K, Kodama A, Takai Y (1998). "Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl". Oncogene. 16 (25): 3279–84. doi:10.1038/sj.onc.1201874. PMID 9681826. S2CID 21445282.
- Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, Jay DG, Hall A (2000). "The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho". Nat. Cell Biol. 2 (5): 281–7. doi:10.1038/35010550. PMID 10806479. S2CID 25353057.
- Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
- Hamada K, Shimizu T, Matsui T, Tsukita S, Tsukita S, Hakoshima T (2001). "Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of the adhesion protein ICAM-2". Acta Crystallogr. D. 57 (Pt 6): 891–2. doi:10.1107/S0907444901005716. PMID 11375520.
- Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, Yonemura S, Yamagishi H, Keppler D, Tsukita S, Tsukita S (2002). "Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes". Nat. Genet. 31 (3): 320–5. doi:10.1038/ng905. PMID 12068294. S2CID 24961102.
- Dickson TC, Mintz CD, Benson DL, Salton SR (2002). "Functional binding interaction identified between the axonal CAM L1 and members of the ERM family". J. Cell Biol. 157 (7): 1105–12. doi:10.1083/jcb.200111076. PMC 2173555. PMID 12070130.
- Haddad LA, Smith N, Bowser M, Niida Y, Murthy V, Gonzalez-Agosti C, Ramesh V (2003). "The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton". J. Biol. Chem. 277 (46): 44180–6. doi:10.1074/jbc.M207211200. PMID 12226091.
PDB 갤러리 | |
|---|---|
|
