Peter Dervan

Peter B. Dervan
Peter B. Dervan 2017 DSC8599.JPG
Born (1945-06-28) June 28, 1945 (age 76)
NationalityAmerican
Alma materBoston College, Yale University
Spouse(s)Jacqueline Barton
AwardsNational Medal of Science (2006)
Scientific career
FieldsOrganic chemistry
InstitutionsYale, Stanford, Caltech
ThesisThe stereochemistry of the thermal rearrangements of trans- and cis-1,2-dialkenylcyclobutanes (1973)
Doctoral advisorJerome A. Berson
Doctoral studentsPeter Schultz, Scott Strobel
Other notable studentsLaura Kiessling (post doc), Eric Kool (post doc), Alanna Schepartz (post doc)
External video
video icon "Science is the most fun in the whole wide world", Medal of Science 50 Videos -- Peter Dervan and Jacqueline Barton, National Science Foundation

Peter B. Dervan (born June 28, 1945) is the Bren Professor of Chemistry at the California Institute of Technology. The primary focus of his research is the development and study of small organic molecules that can sequence-specifically recognize DNA,[1] a field in which he is an internationally recognized authority.[2] The most important of these small molecules are pyrrole–imidazole polyamides.[3] Dervan is credited with influencing "the course of research in organic chemistry through his studies at the interface of chemistry and biology" as a result of his work on "the chemical principles involved in sequence-specific recognition of double helical DNA".[4] He is the recipient of many awards, including the National Medal of Science (2006).[5][6]

Early life and education

Peter B. Dervan was born on June 28, 1945 in Boston, Massachusetts. Dervan received his B.S. degree from Boston College in 1967,[7] where professor Francis Bennett sparked his interest in synthetic organic chemistry.[5] He began graduate studies at the University of Wisconsin then moved with Jerome A. Berson's research group to Yale University where he completed his graduate research in physical organic chemistry,[8] studying ways in which chemical bonds are created and broken apart.[5] He received his Ph.D. degree from Yale in 1972, for The Stereochemistry of the Thermal Rearrangements of Trans-1,2-Dialkenylcyclobutanes and Cis-1,2-Dialkenylcyclobutanes.[9][10] He then became an NIH postdoctoral fellow at Stanford.[7]

경력

1986년 더반

더반은 1973년 칼텍의 화학 조교수가 되어 존 D에 합류했다.[7] 유기화학 그룹의 로버츠, 로버트 G. 버그만, 로버트 엘스워스 아일랜드.[3] 1979년 부교수가 되었고, 1982년 교수가 되었다. 1988년 초대 브렌 화학과 교수로 임명되었다.[11][7] 1994년부터 1999년까지 칼텍 화학공학과장을 지냈다.[12] 더반은 325편 이상의 논문을 발표했고 수백 명의 학생들을 가르쳤다.[8]

더반은 국립과학원(1986년),[13] 미국예술과학원(1987년),[14] 미국철학회(2002년)의 회원이다.[15] 프랑스 과학 아카데미(2000년)[16]도이체 아카데미에 데르 나튀르포르셔 레오폴디나(2004년- [17])의 선출직 위원이다.

더반(Dervan)은 길리어드 과학을 위한 과학 자문 위원회(1987년)의 공동 설립자 겸 창립 회원이다.[18][19][20][21] 그는 1997년부터 벡만 쿨터의 이사회에서 일했다.[22] 예일대 수탁자(2008~2017년)를 지냈다.[12][8] 그는 Scripps 연구소의 과학 주지사 이사회의 일원으로 재직하고 있다.[23] 2014년에는 ACS 화학 생물학 강의를 발표하였다.[24] 2016년 현재 그는 로버트 A의 과학 자문 위원회의 의장이 되었다. 웰치 파운데이션.[25]

리서치

첨단 유기화학 칼텍에서 강의를 하던 중, 더반은 자신의 장래 진로를 안내할 깨달음에 도달했다: 이전에 정의되었던 고전적인 문제를 "닫기" 위해 일하기 보다는, 그는 수년 동안 연구될 수 있는 새로운 연구 분야를 정의하고 "열기"를 추구할 것이다.[3] 그가 선택한 문제는 생물학적 시스템에서의 분자 인식이었다.[5] 그 당시 DNA 염기서열 분석은 초기 단계였고 인간 게놈 프로젝트는 미개척 상태였다. 데르반은 합성 화학에서 나온 아이디어를 생물학과 DNA 연구에 적용하여 DNA 인식에 사용될 새로운 결합 분자를 만들었다.[3]

"I would study weak noncovalent bonds in the most challenging of solvents, water. Therefore, the ‘synthetic objective’ would be the three-dimensional assembly of multiple specific noncovalent bonds in aqueous media. Biological molecules, such as proteins or nucleic acids, would be my target and small molecule synthesis combined with physical characterization and the methods of biology would provide the experimental foundation. I would move from the gas phase world of hydrocarbon rearrangements to the aqueous world of nucleic acids and molecular recognition."[3]

By studying weak intermolecular interactions and creating novel synthetic molecules specific to particular DNA sequences, Dervan has been able to explore the complex biological systems underlying DNA's structure and function.[8] A human cell contains approximately 20,000 genes, whose expression is controlled by the binding of protein transcription factors in the promoter region of each gene.[3] Through pioneering work in DNA recognition,[8] Dervan has determined many of the chemical principles underlying sequence-specific recognition of DNA,[3] and enabled researchers to better understand the mechanism of action of many anti-tumor, anti-viral and anti-biotic drugs.[11]

Dervan determined that small molecules could be synthesized and used to selectively bind DNA at the transcription factor/DNA interface, effectively rewriting the biological codes controlling transcription by acting on the promoters of selected genes.[5] The creation of synthetic small molecules with affinities and sequence specificities for predetermined DNA sequences makes it possible to design cell-permeable molecules for the regulation of gene expression.[7] The use of small molecules to regulate gene expression in living cells has possible application to human medicine.[3][26]

The most important of these small molecules are pyrrole–imidazole polyamides.[26][27] Dervan's lab has identified pairing rules to control the DNA sequence specificity of minor-groove binding polyamides that contain the aromatic ring amino acids hydroxypyrrole (Hp), imidazole (Im), and pyrrole (Py).[28][26][29]

Awards

Dervan has received a number of awards for both research and teaching,[7] including those listed below. He was awarded the 2006 National Medal of Science in 2007 from President George Bush at the White House for “his fundamental research contributions at the interface of organic chemistry and biology” as well as contributions to education and industry.[6][30][5] A minor planet has been named in his honor, 4314 Dervan.[31]

Personal

In 1990, Dervan married Jacqueline Barton, a fellow chemist and professor at Caltech. He has a son, Andrew, from a previous marriage, and a daughter, Elizabeth, from his marriage with Barton.[46][12] All four hold degrees from Yale University.[8]

Selected publications

  • Nickols, N. G.; Dervan, P. B. (2007). "Suppression of Androgen Receptor Mediated Gene Expression by a Sequence-Specific DNA Binding Polyamide". Proc. Natl. Acad. Sci. USA. 104 (25): 10418–10423. Bibcode:2007PNAS..10410418N. doi:10.1073/pnas.0704217104. PMC 1965528. PMID 17566103.

References

  1. ^ Dervan1986, P.B. (1986). "Design of sequence-specific-DNA-binding molecules". Science. 232 (4749): 464–471. Bibcode:1986Sci...232..464D. doi:10.1126/science.2421408. PMID 2421408.
  2. ^ "Caltech Chemist Peter Dervan to Deliver Lecture". Southwestern Newsroom. Retrieved 15 June 2017. “Professor Dervan is an internationally renowned chemist and recognized pioneer in chemical biology."
  3. ^ a b c d e f g h i Dervan, Peter B. (2001). "Molecular Recognition of DNA by Small Molecules (personal essay in acceptance of the Tetrahedron Prize)" (PDF). Bioorganic & Medicinal Chemistry. 9 (9): 2215–2235. doi:10.1016/s0968-0896(01)00262-0. PMID 11553460. Retrieved 14 June 2017.
  4. ^ a b Avery, John (March 29, 1996). "Chemist Wins 1996 Grand Prize from la Maison de la Chimie". Caltech News. Retrieved 14 June 2017.
  5. ^ a b c d e f g Mantell, Suzanne. "A day at the races". Boston College Magazine. Retrieved 14 June 2017.
  6. ^ a b c "2006 National Medal of Science Winners". United States Government. Retrieved 2009-02-08.
  7. ^ a b c d e f "Carl Shipp Marvel Lecturer 2002-03 - Peter B. Dervan". The Department of Chemistry at the University of Illinois. Retrieved 14 June 2017.
  8. ^ a b c d e f Wohl, Shirlee (November 16, 2011). "Peter Dervan, GRD '72". Yale Scientific. Retrieved 14 June 2017.
  9. ^ "Peter B. Dervan". Chemistry Tree. Retrieved 14 June 2017.
  10. ^ Dervan, Peter Brendan (1973). The stereochemistry of the thermal rearrangements of trans- and cis-1,2-dialkenylcyclobutanes (Ph.D. thesis). Yale University. OCLC 418780449 – via ProQuest.
  11. ^ a b "For Your Information". Analytical Chemistry. 60 (6): 379A. 30 May 2012. doi:10.1021/ac00157a715.
  12. ^ a b c d "Pioneering Organic Chemist Elected to Yale Board of Trustees". Yale News. June 4, 2008. Retrieved 14 June 2017.
  13. ^ "Chemists elected to National Academy of Sciences". Chemical & Engineering News. 64 (18): 6. 5 May 1986. doi:10.1021/cen-v064n018.p006a.
  14. ^ "NEWS". Analytical Chemistry. 60 (18): 1029A. September 1988. doi:10.1021/ac00169a711.
  15. ^ "Peter B. Dervan". American Philosophical Society. Retrieved 14 June 2017.
  16. ^ "Peter Dervan". Institute de France Académie des Sciences. Retrieved 14 June 2017.
  17. ^ Schnitzer-Ungefug, Jutta (December 8, 2004). "Deutsche Akademie der Naturforscher Leopoldina wählt neue Mitglieder Prof". Informationsdienst Wissenschaft. Retrieved 14 June 2017.
  18. ^ Jones, Stephanie (1992). The biotechnologists and the evolution of biotech enterprises in the USA and Europe. Basingstoke: Macmillan. p. 39. ISBN 978-0333550212. Retrieved 14 June 2017.
  19. ^ Patrick, Margaret (August 19, 2015). "Gilead Sciences: Investor's Overview of a Leading Biotech Company". Market Realist. Retrieved 14 June 2017.
  20. ^ "gilead sciences inc (GILD:NASDAQ GS)". Bloomberg. Retrieved 14 June 2017.
  21. ^ "10-K405 GILEAD SCIENCES INC filed this Form 10-K405 on 03/31/1998". Investors - Gilead Sciences, Inc. Retrieved 14 June 2017.
  22. ^ "DEF 14A 1 ddef14a.htm DEFINITIVE PROXY STATEMENT FOR BECKMAN COULTER, INC". UNITED STATES SECURITIES AND EXCHANGE COMMISSION. Retrieved 14 June 2017.
  23. ^ "Board of Scientific Governors". The Scripps Research Institute. Retrieved 14 June 2017.
  24. ^ "ACS Chemical Biology Lecture" (PDF). Division of Biological Chemistry. Retrieved 2014-01-15.
  25. ^ "Peter B. Dervan" (PDF). Robert A. Welch Foundation. Retrieved 14 June 2017.
  26. ^ a b c Dervan, Peter B; Edelson, Benjamin S (June 2003). "Recognition of the DNA minor groove by pyrrole-imidazole polyamides". Current Opinion in Structural Biology. 13 (3): 284–299. doi:10.1016/S0959-440X(03)00081-2. PMID 12831879.
  27. ^ Dervan, PB; Edelson, BS (June 2003). "Recognition of the DNA minor groove by pyrrole-imidazole polyamides". Current Opinion in Structural Biology. 13 (3): 284–99. doi:10.1016/s0959-440x(03)00081-2. PMID 12831879.
  28. ^ Swalley, Susanne E.; Baird, Eldon E.; Dervan, Peter B. (October 1997). "A Pyrrole-Imidazole Polyamide Motif for Recognition of Eleven Base Pair Sequences in the Minor Groove of DNA". Chemistry - A European Journal. 3 (10): 1600–1607. doi:10.1002/chem.19970031009.
  29. ^ White, Sarah; Baird, Eldon E.; Dervan, Peter B. (August 1997). "On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides". Chemistry & Biology. 4 (8): 569–578. doi:10.1016/S1074-5521(97)90243-X. PMID 9281524.
  30. ^ National Science Foundation - The President's National Medal of Science
  31. ^ Schmadel, Lutz (2014). Dictionary of Minor Planet Names: Addendum to 6th Edition: 2012-2014. New York: Springer. p. 48. ISBN 9783319176772. Retrieved 14 June 2017.
  32. ^ "Past Recipients of the Harrison Howe Award". Rocherster Section ACS. Retrieved 14 June 2017.
  33. ^ "Arthur C. Cope Award". American Chemical Society. Retrieved 14 June 2017.
  34. ^ "The Willard Gibbs Meda" (PDF). American Chemical Society. Retrieved 14 June 2017.
  35. ^ "AWARDS". Chemical & Engineering News. 72 (13): 48. 28 March 1994. doi:10.1021/cen-v072n013.p048.
  36. ^ "Remsen Award". American Chemistry Society. Archived from the original on 8 March 2015. Retrieved 14 June 2017.
  37. ^ "1998 Remsen Award" (PDF). The Chesapeake Chemist. LIV (5): 1, 4. 1998. Retrieved 14 June 2017.
  38. ^ "Alfred Bader Award in Bioinorganic or Bioorganic Chemistry". American Chemical Society. Retrieved 14 June 2017.
  39. ^ "Max Tishler Prize Lecturers". Harvard University. Retrieved 14 June 2017.
  40. ^ "The Pauling Medal Awardees". The Pauling Blog. April 27, 2016. Retrieved 14 June 2017.
  41. ^ "Tolman Award". SCALACS. 2006-01-10. Retrieved 14 June 2017.
  42. ^ "Prize Winners". Harvey Prize. Retrieved 14 June 2017.
  43. ^ "Ronald Breslow Award for Achievement in Biomimetic Chemistry". American Chemical Society. Retrieved 14 June 2017.
  44. ^ "Medalists by Year". Yale Alumni Association. Retrieved 14 June 2017.
  45. ^ "Frank H. Westheimer Prize Lecturers". Harvard University. Retrieved 14 June 2017.
  46. ^ "Meet Jacqueline K. Barton, 2015 Priestley Medalist". Chemical & Engineering News. 93 (12). Mar 23, 2015. Retrieved 2 April 2015.

External links