PLCG2

PLCG2
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	2K2J, 2W2W, 2W2X
식별자
별칭	PLCG2, APLADE, FCAS3, PLC-IV, PLC-감마-2, 인광 효소 C 감마선 2
외부 ID	OMIM: 600220 MGI: 97616 HomoloGene: 55671 GeneCard: PLCG2
유전자 위치(인간)
쳇.	16번 염색체(인간)
끝	81,962,685bp
유전자 위치(마우스)
쳇.	8번 염색체(쥐)
끝	118,361,881 bp
RNA 표현 패턴
	표현된 상단
	글루머룰루스; ; 흉선; ; 핏덩어리; ; 림프절; ; 메타네프릭 글로머룰루스; ; 비장의; ; 신장 튜울레; ; 부신; ; 맹장;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	신호 변환기 활동; GO:0001948 단백질 결합; 인산 다이제터 수산화효소 활성; 인산염 C 활성; 수산화효소 활동; 인산염리노시톨인산화효소 C 활성; 인산염 잔여물 결합;
셀룰러 컴포넌트	시토솔; 플라즈마 막; 세포외 외성체;
생물학적 과정	B세포수용체신호경로; 격리된 칼슘 이온을 시토솔로 방출; GO:0007243 세포내 신호 전달; 이노시톨 트리스인산염 생합성 과정; 혈소판 감염에 관련된 fc-감마 수용체 신호 경로; 수용체 내장의 양성 조절; 지질 대사; 자극 C형 렉틴 수용체 신호 경로; 이노시톨 인산염 대사 과정; Wnt 신호 경로; 혈소판 활성화; Fc-엡실론 수용체 신호 경로; 지질 투약 과정; 모낭 B 세포 분화; 지용성당류에 대한 반응; 인지질 투약 공정; 유전자 발현 조절; 인산염리노시톨 생합성 과정; 프로그램된 세포 사망에 대한 부정적인 규제; B 세포 분화; T세포수용체신호경로; 매장 운영 칼슘 채널 활동 활성화; I형 인터페론 생산의 양성 규제; 칼슘 매개 신호; 신호 전달; 인지질리노시톨 매개 신호;
	출처:아미고 / 퀵고
직교체
	5336
	234779
	ENSG00000197943
	ENSMUSG00000034330
	P16885
	Q8CIH5
	NM_002661
	NM_172285
	NP_002652
	NP_758489
	위키다타
인간 보기/편집	마우스 보기/편집

1-phosphatidylinositol-4,5-bisphosphate phosphidesterase gamma-2는 인간에서 PLCG2 유전자에 의해 암호화된 효소다.^[5]^[6]

함수

인산염 C 계열의 효소는 인산염의 가수분해를 촉진하여 지질 머리 그룹의 디아실글리세롤과 수용성 인산염 유도체를 산출한다.이 효소들 중 다수는 인지질화물에 대한 특수성을 가지고 있다.인산화인산화인산화효소 C효소 중 C-베타는 이단성 G 단백질 결합 수용체에 의해 조절되며, 밀접하게 연관된 C-감마-1(PLCG1, MIM 172420)과 C-감마-2 효소는 수용체 티로신 키네아제스에 의해 제어된다.C-감마-1과 C-감마-2 효소는 동질학의 영역을 SRC 종균제품인 SH2와 SH3의 비카탈성 영역과 나란히 하는 인지질 영역으로 구성된다.[OMIM에 의해 제공]^[6]

상호작용

PLCG2는 다음과 상호 작용하는 것으로 나타났다.

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000197943 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000034330 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hernandez D, Egan SE, Yulug IG, Fisher EM (February 1995). "Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse". Genomics. 23 (2): 504–7. doi:10.1006/geno.1994.1533. PMID 7835906.
^ ^a ^b "Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)".
^ ^a ^b Guo B, Kato RM, Garcia-Lloret M, Wahl MI, Rawlings DJ (August 2000). "Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex". Immunity. 13 (2): 243–53. doi:10.1016/s1074-7613(00)00024-8. PMID 10981967.
^ Yasuda T, Tezuka T, Maeda A, Inazu T, Yamanashi Y, Gu H, Kurosaki T, Yamamoto T (July 2002). "Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells". J. Exp. Med. 196 (1): 51–63. doi:10.1084/jem.20020068. PMC 2194016. PMID 12093870.
^ ^a ^b ^c Boudot C, Kadri Z, Petitfrère E, Lambert E, Chrétien S, Mayeux P, Haye B, Billat C (October 2002). "Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells". Cell. Signal. 14 (10): 869–78. doi:10.1016/s0898-6568(02)00036-0. PMID 12135708.
^ Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Cambier JC (September 1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): 5877–87. doi:10.1128/MCB.13.9.5877. PMC 360336. PMID 8395016.
^ Perskvist N, Zheng L, Stendahl O (January 2000). "Activation of human neutrophils by Mycobacterium tuberculosis H37Ra involves phospholipase C gamma 2, Shc adapter protein, and p38 mitogen-activated protein kinase". J. Immunol. 164 (2): 959–65. doi:10.4049/jimmunol.164.2.959. PMID 10623845.

추가 읽기

Fruman DA, Satterthwaite AB, Witte ON (2000). "Xid-like phenotypes: a B cell signalosome takes shape". Immunity. 13 (1): 1–3. doi:10.1016/S1074-7613(00)00002-9. PMID 10933389.
Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
Ohta S, Matsui A, Nazawa Y, Kagawa Y (1988). "Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes". FEBS Lett. 242 (1): 31–5. doi:10.1016/0014-5793(88)80979-7. PMID 2849563. S2CID 20986590.
Yan W, Ratnam M (1995). "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal". Biochemistry. 34 (44): 14594–600. doi:10.1021/bi00044a039. PMID 7578066.
Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147.
Liao F, Shin HS, Rhee SG (1993). "In vitro tyrosine phosphorylation of PLC-gamma 1 & PLC-gamma 2 by src-family protein tyrosine kinases". Biochem. Biophys. Res. Commun. 191 (3): 1028–1033. doi:10.1006/bbrc.1993.1320. PMC 298050. PMID 7682059.
Daniel JL, Dangelmaier C, Smith JB (1994). "Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization". Biochem. J. 302 (2): 617–22. doi:10.1042/bj3020617. PMC 1137272. PMID 8093016.
Obermeier A, Lammers R, Wiesmüller KH, Jung G, Schlessinger J, Ullrich A (1993). "Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex". J. Biol. Chem. 268 (31): 22963–6. PMID 8226808.
Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Cambier JC (1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): 5877–87. doi:10.1128/MCB.13.9.5877. PMC 360336. PMID 8395016.
Sidorenko SP, Law CL, Klaus SJ, Chandran KA, Takata M, Kurosaki T, Clark EA (1996). "Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling". Immunity. 5 (4): 353–63. doi:10.1016/S1074-7613(00)80261-7. PMID 8885868.
Kang JS, Kohlhuber F, Hug H, Marmé D, Eick D, Ueffing M (1996). "Cloning and functional analysis of the hematopoietic cell-specific phospholipase C(gamma)2 promoter". FEBS Lett. 399 (1–2): 14–20. doi:10.1016/S0014-5793(96)01276-8. PMID 8980110. S2CID 85872860.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
Cunningham SA, Arrate MP, Brock TA, Waxham MN (1997). "Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites". Biochem. Biophys. Res. Commun. 240 (3): 635–9. doi:10.1006/bbrc.1997.7719. PMID 9398617.
Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685. S2CID 19529677.
Bai RY, Dieter P, Peschel C, Morris SW, Duyster J (1998). "Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity". Mol. Cell. Biol. 18 (12): 6951–61. doi:10.1128/mcb.18.12.6951. PMC 109278. PMID 9819383.
Tomassetti A, Bottero F, Mazzi M, Miotti S, Colnaghi MI, Canevari S (1999). "Molecular requirements for attachment of the glycosylphosphatidylinositol anchor to the human alpha folate receptor". J. Cell. Biochem. 72 (1): 111–8. doi:10.1002/(SICI)1097-4644(19990101)72:1<111::AID-JCB12>3.0.CO;2-1. PMID 10025672.
Shen Z, Batzer A, Koehler JA, Polakis P, Schlessinger J, Lydon NB, Moran MF (1999). "Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src". Oncogene. 18 (33): 4647–53. doi:10.1038/sj.onc.1203079. PMID 10467411.
Gross BS, Melford SK, Watson SP (1999). "Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets". Eur. J. Biochem. 263 (3): 612–23. doi:10.1046/j.1432-1327.1999.00560.x. PMID 10469124.
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179. S2CID 25410140.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000197943 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000034330 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7835906-5] Hernandez D, Egan SE, Yulug IG, Fisher EM (February 1995). "Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse". Genomics. 23 (2): 504–7. doi:10.1006/geno.1994.1533. PMID 7835906.

[entrez-6] "Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)".

[pmid10981967-7] Guo B, Kato RM, Garcia-Lloret M, Wahl MI, Rawlings DJ (August 2000). "Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex". Immunity. 13 (2): 243–53. doi:10.1016/s1074-7613(00)00024-8. PMID 10981967.

[pmid12093870-8] Yasuda T, Tezuka T, Maeda A, Inazu T, Yamanashi Y, Gu H, Kurosaki T, Yamamoto T (July 2002). "Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells". J. Exp. Med. 196 (1): 51–63. doi:10.1084/jem.20020068. PMC 2194016. PMID 12093870.

[pmid12135708-9] Boudot C, Kadri Z, Petitfrère E, Lambert E, Chrétien S, Mayeux P, Haye B, Billat C (October 2002). "Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells". Cell. Signal. 14 (10): 869–78. doi:10.1016/s0898-6568(02)00036-0. PMID 12135708.

[pmid8395016-10] Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Cambier JC (September 1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): 5877–87. doi:10.1128/MCB.13.9.5877. PMC 360336. PMID 8395016.

[pmid10623845-11] Perskvist N, Zheng L, Stendahl O (January 2000). "Activation of human neutrophils by Mycobacterium tuberculosis H37Ra involves phospholipase C gamma 2, Shc adapter protein, and p38 mitogen-activated protein kinase". J. Immunol. 164 (2): 959–65. doi:10.4049/jimmunol.164.2.959. PMID 10623845.

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v t 효소
활동	활성 사이트 바인딩 사이트 촉매삼각형 옥시아니온 구멍 효소 문란성 확산제한효소 코엔자임 공동 인자 효소 촉매제
규정	알로스테릭 규제 협력성 효소억제제 효소활성화제
분류	EC 번호 효소 슈퍼 패밀리 효소군 효소 목록
키네틱스	효소동력학 이디-호프스티 도표 하네스-울프 플롯 라인위버-버크 플롯 미카엘리스-멘텐 운동학
종류들	EC1 산화효소(목록) EC2 전송(목록) EC3 하이드롤라제(목록) EC4 Lyases(목록) EC5 Isomeras(목록) EC6 리거스(목록) EC7 변환기(목록)

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PLCG2

네임스페이스

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목차

함수

상호작용

참조

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