이중특이성 티로신인산화효소2 는 DYRK2 [5] [6] 유전자 에 의해 인간에게 부호화되는 효소 , 특히 이중특이성 키나제이다.
DYRK2는 세포 성장 과 발달에 관여하는 것으로 추정되는 단백질 키나아제군에 속한다. 이 패밀리는 키나아제 도메인의 구조적 유사성과 티로신 잔기에 대한 자동인산 처리 능력에 의해 정의된다. DYRK2는 시험관내 히스톤 H3 및 H2B의 티로신 자가인산화와 촉매인산화 현상을 입증했다. DYRK2의 두 개 의 Isoforms가 분리되었습니다. 주요 Isoform인 isoform 1에는 5' 단자 [6]
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000127334 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000028630 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG (Nov 1998). "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases" . J Biol Chem . 273 (40): 25893–902. doi :10.1074/jbc.273.40.25893 PMID 9748265 . ^ a b "Entrez Gene: DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2" .
추가 정보 Woods YL, Cohen P, Becker W, et al. (2001). "The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase" . Biochem. J . 355 (Pt 3): 609–15. doi :10.1042/bj3550609 . PMC 1221774 PMID 11311121 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Wang X, Li W, Parra JL, et al. (2003). "The C Terminus of Initiation Factor 4E-Binding Protein 1 Contains Multiple Regulatory Features That Influence Its Function and Phosphorylation" . Mol. Cell. Biol . 23 (5): 1546–57. doi :10.1128/MCB.23.5.1546-1557.2003 . PMC 151707 PMID 12588975 . Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases" . J. Biol. Chem . 279 (4): 2490–8. doi :10.1074/jbc.M301769200 PMID 14593110 . Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Taira N, Nihira K, Yamaguchi T, et al. (2007). "DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage" . Mol. Cell . 25 (5): 725–38. doi :10.1016/j.molcel.2007.02.007 PMID 17349958 .
