구아닌 뉴클레오티드 결합 단백질 G(I)/G(S)/G(O) 서브유닛 감마-11 은 인간에서 GNG11 유전자 에 의해 인코딩되는 단백질 이다.[5] [6]
이 유전자는 구아닌 뉴클레오티드결합단백질(G단백질 ) 감마과에 속하는 성분으로 지질에 부착된 세포막단백질을 인코딩한다.
이단자 G 단백질 복합체 의 구성원으로서 이 단백질은 이 투과 신호 시스템에 역할을 한다.이 단백질은 또한 카복실-단말기 처리의 대상이 된다. 이 유전자의 발현 감소는 비장 한계영역 림프종 과 관련이 있다.[6]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000127920 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000032766 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ray K, Kunsch C, Bonner LM, Robishaw JD (Oct 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits" . J Biol Chem . 270 (37): 21765–71. doi :10.1074/jbc.270.37.21765 PMID 7665596 . ^ a b "Entrez Gene: GNG11 guanine nucleotide binding protein (G protein), gamma 11" . 추가 읽기 Downes GB, Gautam N (2000). "The G protein subunit gene families". Genomics . 62 (3): 544–52. doi :10.1006/geno.1999.5992 . PMID 10644457 . Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence" . Genome Res . 8 (11): 1097–108. doi :10.1101/gr.8.11.1097 PMID 9847074 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta" . J. Biol. Chem . 278 (9): 7220–6. doi :10.1074/jbc.M210304200 PMID 12486123 . Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology" . Science . 300 (5620): 767–72. Bibcode :2003Sci...300..767S . doi :10.1126/science.1083423 . PMC 2882961 PMID 12690205 . Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7" . Nature . 424 (6945): 157–64. Bibcode :2003Natur.424..157H . doi :10.1038/nature01782 PMID 12853948 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–5. Bibcode :2005Sci...307.1621B . doi :10.1126/science.1105776 . PMID 15761153 . S2CID 39457788 . Ruiz-Ballesteros E, Mollejo M, Rodriguez A, et al. (2005). "Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis". Blood . 106 (5): 1831–8. doi :10.1182/blood-2004-10-3898 . PMID 15914563 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Hossain MN, Sakemura R, Fujii M, Ayusawa D (2007). "G-protein gamma subunit GNG11 strongly regulates cellular senescence". Biochem. Biophys. Res. Commun . 351 (3): 645–50. doi :10.1016/j.bbrc.2006.10.112 . PMID 17092487 .
