GNG2
GNG2| GNG2 | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 별칭 | GNG2, G단백질 서브유닛 감마 2 | ||||||||||||||||||||||||
| 외부 ID | OMIM: 606981 MGI: 102705 HomoloGene: 40715 GeneCard: GNG2 | ||||||||||||||||||||||||
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| 직교체 | |||||||||||||||||||||||||
| 종 | 인간 | 마우스 | |||||||||||||||||||||||
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| RefSeq(mRNA) |
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| RefSeq(단백질) |
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| 위치(UCSC) | Cr 14: 51.83 – 51.98Mb | Chr 14: 19.92 – 20.03Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
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구아닌 뉴클레오티드 결합 단백질 G(I)/G(S)/G(O) 서브유닛 감마-2는 인간에서 GNG2 유전자에 의해 인코딩되는 단백질이다.[5][6]
이질성 G 단백질은 외부 신호에 대한 세포 반응에서 중요한 역할을 한다.G 단백질-수용체 상호작용의 특수성은 주로 감마 서브유닛에 의해 매개된다.[OMIM에 의해 제공][6]
대화형 경로 지도
각 기사에 연결하려면 아래의 유전자, 단백질, 대사물을 클릭하십시오.[§ 1]
도파민성 뉴런의 니코틴 활성도 분석
- ^ 대화형 경로 맵은 WikiPathways에서 편집할 수 있다."NicotineDopaminergic_WP1602".
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000186469 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000043004 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Modarressi MH, Taylor KE, Wolfe J (Jul 2000). "Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit". Biochem Biophys Res Commun. 272 (2): 610–5. doi:10.1006/bbrc.2000.2832. PMID 10833460.
- ^ a b "Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2".
추가 읽기
- Pumiglia KM, LeVine H, Haske T, et al. (1995). "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase". J. Biol. Chem. 270 (24): 14251–4. doi:10.1074/jbc.270.24.14251. PMID 7782277.
- Tsukada S, Simon MI, Witte ON, Katz A (1994). "Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11256–60. Bibcode:1994PNAS...9111256T. doi:10.1073/pnas.91.23.11256. PMC 45206. PMID 7972043.
- Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
- De Waard M, Liu H, Walker D, et al. (1997). "Direct binding of G-protein betagamma complex to voltage-dependent calcium channels". Nature. 385 (6615): 446–50. Bibcode:1997Natur.385..446W. doi:10.1038/385446a0. PMID 9009193. S2CID 4287544.
- Kostenis E, Conklin BR, Wess J (1997). "Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits". Biochemistry. 36 (6): 1487–95. doi:10.1021/bi962554d. PMID 9063897.
- Qin N, Platano D, Olcese R, et al. (1997). "Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8866–71. Bibcode:1997PNAS...94.8866Q. doi:10.1073/pnas.94.16.8866. PMC 23172. PMID 9238069.
- Ong OC, Hu K, Rong H, et al. (1997). "Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2)". Genomics. 44 (1): 101–9. doi:10.1006/geno.1997.4814. PMID 9286705.
- Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS Lett. 459 (2): 186–90. doi:10.1016/S0014-5793(99)01244-2. PMID 10518015.
- Carman CV, Barak LS, Chen C, et al. (2000). "Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2". J. Biol. Chem. 275 (14): 10443–52. doi:10.1074/jbc.275.14.10443. PMID 10744734.
- Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB (2001). "Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq". J. Biol. Chem. 276 (26): 23945–53. doi:10.1074/jbc.M101154200. PMID 11294873.
- Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
- Lowry WE, Huang XY (2002). "G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase". J. Biol. Chem. 277 (2): 1488–92. doi:10.1074/jbc.M110390200. PMID 11698416.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
- Melliti K, Grabner M, Seabrook GR (2003). "The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells". J. Physiol. 546 (Pt 2): 337–47. doi:10.1113/jphysiol.2002.026716. PMC 2342512. PMID 12527722.
- Wolfe JT, Wang H, Howard J, et al. (2003). "T-type calcium channel regulation by specific G-protein betagamma subunits". Nature. 424 (6945): 209–13. Bibcode:2003Natur.424..209W. doi:10.1038/nature01772. PMID 12853961. S2CID 4414712.
- Niu J, Profirovic J, Pan H, et al. (2003). "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production". Circ. Res. 93 (9): 848–56. doi:10.1161/01.RES.0000097607.14733.0C. PMID 14512443.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Doering CJ, Kisilevsky AE, Feng ZP, et al. (2004). "A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels". J. Biol. Chem. 279 (28): 29709–17. doi:10.1074/jbc.M308693200. PMID 15105422.
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