구아닌 뉴클레오티드 결합 단백질 서브유닛 베타-5 는 인간에서 GNB5 유전자 에 의해 암호화된 단백질 이다.[5] 또는 다른 ISO 양식을 인코딩하는 분할된 대본 변형이 존재한다.[6]
함수 수용체와 이펙터 단백질 사이에 신호를 통합하는 이질구아닌 뉴클레오티드결합단백질(G단백질 )은 알파와 베타, 감마 서브유닛으로 구성된다. 이 하위 유니트는 관련 유전자의 가족에 의해 암호화된다. 이 유전자는 베타 서브 유닛을 암호로 한다. 베타 서브유닛은 특정 신호 전달 수용체와 이펙터뿐만 아니라 알파 서브유닛의 중요한 조절기다.[6]
GNB5는 RGS 단백질 안정성과 멤브레인 앵커 결합을 차등 제어하는 것으로 나타났으며, 따라서 복잡한 뉴런 G 단백질 신호 전달 경로의 제어에 관여한다.[7]
상호작용 GNB5는 다음과 상호 작용하는 것으로 나타났다.
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000069966 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000032192 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Jones PG, Lombardi SJ, Cockett MI (Jun 1998). "Cloning and tissue distribution of the human G protein beta 5 cDNA" . Biochim. Biophys. Acta . 1402 (3): 288–91. doi :10.1016/S0167-4889(98)00017-2 PMID 9606987 . ^ a b "Entrez Gene: GNB5 guanine nucleotide binding protein (G protein), beta 5" .^ a b Masuho I, Wakasugi-Masuho H, Posokhova EN, Patton JR, Martemyanov KA (June 2011). "Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors" . J. Biol. Chem . 286 (24): 21806–13. doi :10.1074/jbc.M111.241513 PMC 3122235 PMID 21511947 . ^ Yan K, Kalyanaraman V, Gautam N (March 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families" . J. Biol. Chem . 271 (12): 7141–6. doi :10.1074/jbc.271.12.7141 PMID 8636150 . ^ Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (December 2001). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)" . J. Biol. Chem . 276 (52): 49267–74. doi :10.1074/jbc.M106565200 PMID 11675383 . ^ Levay K, Cabrera JL, Satpaev DK, Slepak VZ (March 1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins" . Proc. Natl. Acad. Sci. U.S.A . 96 (5): 2503–7. Bibcode :1999PNAS...96.2503L . doi :10.1073/pnas.96.5.2503 PMC 26814 PMID 10051672 . ^ Posner BA, Gilman AG, Harris BA (October 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways" . J. Biol. Chem . 274 (43): 31087–93. doi :10.1074/jbc.274.43.31087 PMID 10521509 .
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