이중특이성 단백질 포스파타아제 16 은 DUSP16 [5] [6] [7] [8] 효소 이다.
마이트젠 활성화 단백질 키나제(MAPK)의 활성화는 다양한 세포외 신호를 핵으로 전달하여 유전자 발현, 세포 증식, 분화, 세포 주기 정지 및 아포토시스를 유도한다. MAPK의 완전한 활성화를 위해 이중특이성 키나아제들은 MAPK TXY 모티브에서 트레오닌 및 티로신 잔기를 모두 인산화한다. MKP는 TXY 모티브를 탈인산화하는 이중 특이성 포스파타아제이며, 따라서 MAPK 활성을 음성적으로 조절한다. [OMIM [8]
상호 작용 DUSP16은 MAPK14 [9] [10] MAPK8 과 상호 작용하는 것 으로 나타났습니다. IP1 .[11]
레퍼런스 ^ a b c ENSG0000011266 GRCh38: 앙상블 릴리즈 89: ENSG00000280962, ENSG00000111266 : Ensembl , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000030203 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs" . J Biol Chem . 276 (28): 26629–39. doi :10.1074/jbc.M101981200 PMID 11359773 . ^ Masuda K, Shima H, Watanabe M, Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein" . J Biol Chem . 276 (42): 39002–11. doi :10.1074/jbc.M104600200 PMID 11489891 . ^ Willoughby EA, Collins MK (Jul 2005). "Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2" . J Biol Chem . 280 (27): 25651–8. doi :10.1074/jbc.M501926200 PMID 15888437 . ^ a b "Entrez Gene: DUSP16 dual specificity phosphatase 16" .^ Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs" . J. Biol. Chem . United States. 276 (28): 26629–39. doi :10.1074/jbc.M101981200 ISSN 0021-9258 . PMID 11359773 . ^ Masuda, K; Shima H; Watanabe M; Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein" . J. Biol. Chem . United States. 276 (42): 39002–11. doi :10.1074/jbc.M104600200 ISSN 0021-9258 . PMID 11489891 . ^ Willoughby, Emma A; Perkins Gordon R; Collins Mary K; Whitmarsh Alan J (Mar 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK" . J. Biol. Chem . United States. 278 (12): 10731–6. doi :10.1074/jbc.M207324200 ISSN 0021-9258 . PMID 12524447 .
추가 정보 Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (6): 347–55. doi :10.1093/dnares/7.6.347 PMID 11214970 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Willoughby EA, Perkins GR, Collins MK, Whitmarsh AJ (2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK" . J. Biol. Chem . 278 (12): 10731–6. doi :10.1074/jbc.M207324200 PMID 12524447 . Masuda K, Shima H, Katagiri C, Kikuchi K (2003). "Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446" . J. Biol. Chem . 278 (34): 32448–56. doi :10.1074/jbc.M213254200 PMID 12794087 . Hoornaert I, Marynen P, Goris J, et al. (2003). "MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation" . Oncogene . 22 (49): 7728–36. doi :10.1038/sj.onc.1207089 PMID 14586399 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Katagiri C, Masuda K, Urano T, et al. (2005). "Phosphorylation of Ser-446 determines stability of MKP-7" . J. Biol. Chem . 280 (15): 14716–22. doi :10.1074/jbc.M500200200 PMID 15689616 . 외부 링크 PDBe-KB 는 PDB for Human Dual specificity 단백질 포스파타아제 16에서 사용 가능한 모든 구조 정보에 대한 개요를 제공합니다.
