호모 사피엔스 종의 단백질 코드 유전자
이중특이성 단백질 포스파타아제 CDC14A 는 사람 에게서 CDC14A [5] [6] [7] 효소 이다.
이 유전자에 의해 암호화된 단백질은 이중 특이성 단백질 티로신 포스파타아제 계열의 구성원이다. 이 단백질은 세포 유사분열 출구 및 DNA 복제 개시에 관여하는 단백질 티로신 포스파타아제인 사카로미세스 세레비시아 Cdc14와 매우 유사하며, 이는 세포 주기 제어에 역할을 시사한다. 이 단백질은 종양억제단백질 p53과 상호작용하고 탈인산화하는 것으로 나타났으며 p53의 기능을 조절하는 것으로 생각된다. 이 유전자의 대체 스플라이스는 구별되는 [7]
상호 작용 CDC14A는 P53 과 [8] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000079335 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000033502 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (December 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast" . J Biol Chem . 272 (47): 29403–6. doi :10.1074/jbc.272.47.29403 PMID 9367992 . ^ Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH (September 1999). "Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene". Genomics . 59 (2): 248–51. doi :10.1006/geno.1999.5863 . PMID 10409437 . ^ a b "Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)" .^ Li, L; Ljungman M; Dixon J E (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53" . J. Biol. Chem . 275 (4): 2410–4. doi :10.1074/jbc.275.4.2410 ISSN 0021-9258 . PMID 10644693 .
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