원산지 인식 복합소단위 1 은 인간에서 ORC1 유전자 에 의해 인코딩 되는 단백질이다.[5] [6] CDC6 와 밀접한 관계가 있으며, 둘 다 고고학 에서 같은 단백질이다.[7]
함수 원산지 인식 콤플렉스 (ORC)는 진핵세포에서 DNA 복제 를 시작하는 데 필수적인 6개의 서브유닛 단백질 콤플렉스다.효모에 대한 연구는 ORC가 복제의 기원에 특별히 결합하고 Cdc6 와 Mcm 단백질과 같은 추가적인 개시 요소를 포함하는 복제 전 복합체 의 조립을 위한 플랫폼 역할을 한다는 것을 증명했다. 이 유전자가 인코딩한 단백질은 원산지 인식 콤플렉스 중 가장 큰 단위다. 다른 ORC 하위유닛은 세포 주기 전반에 걸쳐 안정적이지만, 이 단백질의 수준은 세포 주기 동안 달라지는데, 이는 DNA 복제가 시작된 후 유비퀴틴 매개 단백질 분해에 의해 제어되는 것으로 나타났다. 이 단백질은 유사시 선택적으로 인산화 되는 것으로 밝혀졌다. 또한 전사 음소거 제어에 관여하는 단백질인 MIST 히스톤 아세틸트랜스퍼레이즈 2 (MYST2/HBO1)와도 상호작용하는 것으로 보고되고 있다.[6]
상호작용 ORC1은 다음과 상호작용 하는 것으로 나타났다.
CDC45 관련 단백질 [8] CDC6 ,[8] [9] 세포분할 주기 7 관련 단백질 키나아제 ,[8] 사이클린 의존성 [10] 키나제 2,MCM2 ,[8] MCM4 ,[8] MCM6 ,[8] MCM7 ,[8] MISS2 ,[11] ORC2 ,[8] [12] [13] [10] ORC4 ,[8] ORC5 [8] SKP2 .[10]
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