ORC5

ORC5
식별자
별칭	ORC5, ORC5L, ORC5P, ORC5T, PPP1R117, 원산지 인식 복합체 5
외부 ID	OMIM: 602331 MGI: 1347044 호몰로진: 37636 GeneCard: ORC5
유전자 위치(인간)
쳇.	7번 염색체(인간)
끝	104,104,047 bp
유전자 위치(마우스)
쳇.	5번 염색체(쥐)
끝	22,755,427 bp
RNA 표현 패턴
	표현된 상단
	2차 난모세포; ; 내피 세포; ; 중간 측두회; ; 브로드만 23구역; ; 아킬레스건; ; 췌장체; ; 직장의; ; 전두엽 피질; ; 강리온의 명성; ; 고환;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	뉴클레오티드 결합; DNA 복제 원본 바인딩; GO:0001948 단백질 결합; ATP 바인딩; 분자 함수;
셀룰러 컴포넌트	복제 인식 복합체의 핵 원점; 원산지 인식 콤플렉스; 핵의; 핵종의; 시토솔;
생물학적 과정	G1상; DNA 복제; DNA 복제 시작; 유사 세포 주기의 G1/S 전환;
	출처:아미고 / 퀵고
직교체
	5001
	26429
	ENSG00000164815
	ENSMUSG00000029012
	O43913
	Q9WUV0
	NM_001197292; NM_002553; NM_181747
	NM_011959
	NP_002544; NP_859531
	NP_036089
	위키다타
인간 보기/편집	마우스 보기/편집

원산지 인식 복합체 5단위는 인간에서 ORC5(ORC5L) 유전자에 의해 인코딩되는 단백질이다.^[5]^[6]^[7]

함수

원산지 인식 콤플렉스(ORC)는 진핵 세포에서 DNA 복제를 시작하는 데 필수적인 6개 서브유닛 단백질 콤플렉스다.효모에 대한 연구는 ORC가 복제의 기원에 특별히 결합하고 있으며 Cdc6와 Mcm 단백질과 같은 추가 개시 인자의 조립을 위한 플랫폼 역할을 한다는 것을 입증했다.이 유전자에 의해 인코딩된 단백질은 ORC 복합체의 서브 유닛이다.ORC2L, -3L, 4L로 핵심단지를 형성하는 것으로 나타났다.또는 구별되는 ISO 양식을 인코딩하는 분할된 대본 변형이 설명되었다.^[7]

상호작용

ORC5는 다음과 상호작용하는 것으로 나타났다.

MCM2,^[8]
MCM3,^[8]
MCM4,^[8]
MCM7,^[8]
ORC1,^[8]
ORC2,^[8]^[9]^[10]^[11]
ORC3 ^[8]^[10]^[11]^[12]및
ORC4.^[8]^[9]^[10]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000164815 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000029012 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishiai M, Dean FB, Okumura K, Abe M, Moon KY, Amin AA, Kagotani K, Taguchi H, Murakami Y, Hanaoka F, O'Donnell M, Hurwitz J, Eki T (Dec 1997). "Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22". Genomics. 46 (2): 294–8. doi:10.1006/geno.1997.5003. PMID 9417919.
^ Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972.
^ ^a ^b "Entrez Gene: ORC5L origin recognition complex, subunit 5-like (yeast)".
^ ^a ^b ^c ^d ^e ^f ^g ^h Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
^ ^a ^b Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". The Journal of Biological Chemistry. 273 (42): 27137–45. doi:10.1074/jbc.273.42.27137. PMID 9765232.
^ ^a ^b ^c Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.
^ ^a ^b Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.
^ Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi:10.1016/s0896-6273(00)80752-7. PMID 10402192. S2CID 781511.

추가 읽기

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Klemm RD, Austin RJ, Bell SP (Feb 1997). "Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex". Cell. 88 (4): 493–502. doi:10.1016/S0092-8674(00)81889-9. PMID 9038340. S2CID 12927727.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". The Journal of Biological Chemistry. 273 (42): 27137–45. doi:10.1074/jbc.273.42.27137. PMID 9765232.
Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". The EMBO Journal. 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMC 1171637. PMID 10523313.
Thome KC, Dhar SK, Quintana DG, Delmolino L, Shahsafaei A, Dutta A (Nov 2000). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". The Journal of Biological Chemistry. 275 (45): 35233–41. doi:10.1074/jbc.M005765200. PMID 10954718.
Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.
Fröhling S, Nakabayashi K, Scherer SW, Döhner H, Döhner K (Apr 2001). "Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22". Human Genetics. 108 (4): 304–9. doi:10.1007/s004390100498. PMID 11379876. S2CID 23879624.
Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.
Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612.
Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J (Jul 2004). "Self-assembling protein microarrays". Science. 305 (5680): 86–90. doi:10.1126/science.1097639. PMID 15232106. S2CID 20936301.

인간 7번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000164815 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000029012 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9417919-5] Ishiai M, Dean FB, Okumura K, Abe M, Moon KY, Amin AA, Kagotani K, Taguchi H, Murakami Y, Hanaoka F, O'Donnell M, Hurwitz J, Eki T (Dec 1997). "Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22". Genomics. 46 (2): 294–8. doi:10.1006/geno.1997.5003. PMID 9417919.

[pmid9829972-6] Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972.

[entrez-7] "Entrez Gene: ORC5L origin recognition complex, subunit 5-like (yeast)".

[pmid12614612-8] ^ ^a ^b ^c ^d ^e ^f ^g ^h Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.

[pmid9765232-9] Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". The Journal of Biological Chemistry. 273 (42): 27137–45. doi:10.1074/jbc.273.42.27137. PMID 9765232.

[pmid11395502-10] Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.

[pmid11323433-11] Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.

[pmid10402192-12] Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi:10.1016/s0896-6273(00)80752-7. PMID 10402192. S2CID 781511.

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ORC5

네임스페이스

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목차

함수

상호작용

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