MCM2

MCM2
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	4UUZ, 50BNV, 5BNX, 5BO0, 5C3I, 5JA4
식별자
별칭	MCM2, BM28, CCNL1, CDCL1, D3S3194, MITOTIN, CDc19, 미니크로모솜 유지관리 복합 구성요소 2, DFNA70
외부 ID	OMIM: 116945 MGI: 105380 HomoloGene: 3325 GeneCard: MCM2
유전자 위치(인간)
쳇.	3번 염색체(인간)
끝	127,622,436 bp
유전자 위치(마우스)
쳇.	6번 염색체(쥐)
끝	88,875,762 bp
RNA 표현 패턴
	표현된 상단
	난모세포; ; 2차 난모세포; ; 태아; ; 강리온의 명성; ; 폐골.; ; 골수 세포; ; 맹장; ; 자궁내막 세포; ; 모낭; ; 태반의;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	DNA 결합; 뉴클레오티드 결합; GO:0008026 헬리카아제 활동; 히스톤 바인딩; 금속 이온 결합; GO:0004003 DNA 헬리코아제 활성; GO:0001948 단백질 결합; 효소 결합; DNA 복제 원본 바인딩; 수산화효소 활동; ATP 바인딩; 단일 가닥의 DNA 결합; GO:0043142 단일 가닥 DNA 헬리코아제 활성; GO:0043140 3'-5' DNA 헬리코아제 활성;
셀룰러 컴포넌트	세포질; 미세관 사이토스켈레톤; 핵종의; 복제 인식 복합체의 핵 원점; 염색질; MCM 복합체; 핵의; 시토솔; 뉴클레오루스;
생물학적 과정	인터루킨-4에 대한 세포 반응; 뉴클레오솜 조립체; G1상; DNA 복제; DNA 복제 시작; DNA 복제에 관여하는 DNA 풀림; 사멸적 과정; 세포 순환; 골레아 개발; 유사 세포 주기의 G1/S 전환; DNA 헬리코아제 활성에 대한 부정적 규제; 파손에 의한 복제를 통한 이중 패시브 파손 수리; 핵 세포 주기 DNA 복제와 관련된 복제 전 복합체 조립; 유사 DNA 복제 시작;
	출처:아미고 / 퀵고
직교체
	4171
	17216
	ENSG00000073111
	ENSMUSG00000002870
	P49736
	P97310
	NM_004526
	NM_008564
	NP_004517
	NP_032590
	위키다타
인간 보기/편집	마우스 보기/편집

DNA 복제 라이선스 인자 MCM2는 인간에게 MCM2 유전자에 의해 암호화된 단백질이다.^[5]^[6]

함수

이 유전자에 의해 암호화된 단백질은 진핵 게놈 복제의 시작에 관여하는 보존도가 높은 MCM(미니크로모솜 유지 단백질) 중 하나이다.MCM 단백질에 의해 형성된 육각 단백질 복합체는 복제 전 복합체(pre-RC)의 핵심 성분으로 복제 포크 형성과 다른 DNA 복제 관련 단백질의 모집에 관여할 수 있다.이 단백질은 MCM4, 6, 7과 콤플렉스를 형성하며 콤플렉스의 헬리코아제 활성을 조절하는 것으로 나타났다.이 단백질은 인산염화되므로 단백질 키나제 CDC2와 CDC7에 의해 조절된다.^[7]

상호작용

MCM2는 다음과 상호 작용하는 것으로 나타났다.

참고 항목

미니 염색체 유지 관리

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG000073111 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG00000002870 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle". Biochem Biophys Res Commun. 177 (1): 395–400. doi:10.1016/0006-291X(91)91996-P. PMID 1710453.
^ Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21". Cytogenet Cell Genet. 65 (4): 276–7. doi:10.1159/000133647. PMID 8258304.
^ "Entrez Gene: MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)".
^ Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (Jul 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. 278 (29): 26750–6. doi:10.1074/jbc.M300765200. PMID 12740381.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
^ ^a ^b ^c Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells. 8 (5): 413–21. doi:10.1046/j.1365-2443.2003.00645.x. PMID 12694531. S2CID 27707848.
^ ^a ^b ^c You Z, Komamura Y, Ishimi Y (Dec 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. 19 (12): 8003–15. doi:10.1128/MCB.19.12.8003. PMC 84885. PMID 10567526.
^ Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (Sep 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650.
^ DaFonseca CJ, Shu F, Zhang JJ (Mar 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. Bibcode:2001PNAS...98.3034D. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ ^a ^b You Z, Ishimi Y, Masai H, Hanaoka F (Nov 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. 277 (45): 42471–9. doi:10.1074/jbc.M205769200. PMID 12207017.
^ Fujita M, Kiyono T, Hayashi Y, Ishibashi M (Apr 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751.

추가 읽기

Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
Nakatsuru S, Sudo K, Nakamura Y (1995). "Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication". Cytogenet. Cell Genet. 68 (3–4): 226–30. doi:10.1159/000133918. PMID 7842741.
Todorov IT, Pepperkok R, Philipova RN, Kearsey SE, Ansorge W, Werner D (1994). "A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division". J. Cell Sci. 107 (1): 253–65. doi:10.1242/jcs.107.1.253. PMID 8175912.
Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650.
Fujita M, Yamada C, Tsurumi T, Hanaoka F, Matsuzawa K, Inagaki M (1998). "Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase". J. Biol. Chem. 273 (27): 17095–101. doi:10.1074/jbc.273.27.17095. PMID 9642275.
Jiang W, McDonald D, Hope TJ, Hunter T (1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". EMBO J. 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMC 1171637. PMID 10523313.
You Z, Komamura Y, Ishimi Y (2000). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. 19 (12): 8003–15. doi:10.1128/MCB.19.12.8003. PMC 84885. PMID 10567526.
Ishimi Y, Komamura-Kohno Y, You Z, Omori A, Kitagawa M (2000). "Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2". J. Biol. Chem. 275 (21): 16235–41. doi:10.1074/jbc.M909040199. PMID 10748114.
Masai H, Matsui E, You Z, Ishimi Y, Tamai K, Arai K (2000). "Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 bY Cdks". J. Biol. Chem. 275 (37): 29042–52. doi:10.1074/jbc.M002713200. PMID 10846177.
Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon KY, Hurwitz J, Yatagai F, Hanaoka F (2001). "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase". Nucleic Acids Res. 28 (23): 4769–77. doi:10.1093/nar/28.23.4769. PMC 115166. PMID 11095689.
Burke TW, Cook JG, Asano M, Nevins JR (2001). "Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1". J. Biol. Chem. 276 (18): 15397–408. doi:10.1074/jbc.M011556200. PMID 11278932.
Tan DF, Huberman JA, Hyland A, Loewen GM, Brooks JS, Beck AF, Todorov IT, Bepler G (2002). "MCM2--a promising marker for premalignant lesions of the lung: a cohort study". BMC Cancer. 1: 6. doi:10.1186/1471-2407-1-6. PMC 35283. PMID 11472637.
Ishimi Y, Komamura-Kohno Y, Arai K, Masai H (2001). "Biochemical activities associated with mouse Mcm2 protein". J. Biol. Chem. 276 (46): 42744–52. doi:10.1074/jbc.M106861200. PMID 11568184.
Wohlschlegel JA, Dhar SK, Prokhorova TA, Dutta A, Walter JC (2002). "Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45". Mol. Cell. 9 (2): 233–40. doi:10.1016/S1097-2765(02)00456-2. PMID 11864598.
Kodani I, Shomori K, Osaki M, Kuratate I, Ryoke K, Ito H (2002). "Expression of minichromosome maintenance 2 (MCM2), Ki-67, and cell-cycle-related molecules, and apoptosis in the normal-dysplasia-carcinoma sequence of the oral mucosa". Pathobiology. 69 (3): 150–8. doi:10.1159/000048770. PMID 11872961. S2CID 11047685.
Edwards MC, Tutter AV, Cvetic C, Gilbert CH, Prokhorova TA, Walter JC (2002). "MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts". J. Biol. Chem. 277 (36): 33049–57. doi:10.1074/jbc.M204438200. PMID 12087101.
Osaki M, Osaki M, Yamashita H, Shomori K, Yoshida H, Ito H (2003). "Expression of minichromosome maintenance-2 in human malignant fibrous histiocytomas: Correlations with Ki-67 and P53 expression, and apoptosis". Int. J. Mol. Med. 10 (2): 161–8. doi:10.3892/ijmm.10.2.161. PMID 12119552.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG000073111 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG00000002870 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1710453-5] Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle". Biochem Biophys Res Commun. 177 (1): 395–400. doi:10.1016/0006-291X(91)91996-P. PMID 1710453.

[pmid8258304-6] Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21". Cytogenet Cell Genet. 65 (4): 276–7. doi:10.1159/000133647. PMID 8258304.

[entrez-7] "Entrez Gene: MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)".

[pmid12740381-8] Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (Jul 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. 278 (29): 26750–6. doi:10.1074/jbc.M300765200. PMID 12740381.

[pmid12614612-9] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.

[pmid12694531-10] Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells. 8 (5): 413–21. doi:10.1046/j.1365-2443.2003.00645.x. PMID 12694531. S2CID 27707848.

[pmid10567526-11] You Z, Komamura Y, Ishimi Y (Dec 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. 19 (12): 8003–15. doi:10.1128/MCB.19.12.8003. PMC 84885. PMID 10567526.

[pmid8798650-12] Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (Sep 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650.

[pmid11248027-13] DaFonseca CJ, Shu F, Zhang JJ (Mar 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. Bibcode:2001PNAS...98.3034D. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027.

[pmid16189514-14] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid12207017-15] You Z, Ishimi Y, Masai H, Hanaoka F (Nov 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. 277 (45): 42471–9. doi:10.1074/jbc.M205769200. PMID 12207017.

[pmid9099751-16] Fujita M, Kiyono T, Hayashi Y, Ishibashi M (Apr 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751.

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Search

MCM2

네임스페이스

더

목차

함수

상호작용

참고 항목

참조

추가 읽기