ORC4

ORC4
식별자
별칭	ORC4, ORC4L, ORC4P, 원산지 인식 복합체 4
외부 ID	OMIM: 603056 MGI: 1347043 HomoloGene: 8059 GeneCard: ORC4
유전자 위치(인간)
쳇.	염색체 2 (인간)
끝	148,021,604 bp
유전자 위치(마우스)
쳇.	염색체 2 (쥐)
끝	48,840,289 bp
RNA 표현 패턴
	표현된 상단
	아킬레스건; ; 난모세포; ; 랑게르한스 섬; ; 강리온의 명성; ; 신장 튜울레; ; 기관지 상피 세포; ; 말뭉치 담낭; ; 내피 세포; ; 오른쪽 자궁관; ; 우심실;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	뉴클레오티드 결합; DNA 결합; DNA 복제 원본 바인딩; GO:0001948 단백질 결합; ATP 바인딩;
셀룰러 컴포넌트	복제 인식 복합체의 핵 원점; 뉴클레오루스; 원산지 인식 콤플렉스; 핵의; 핵종의; 시토솔;
생물학적 과정	G1상; DNA 복제; DNA 복제 시작; 유사 세포 주기의 G1/S 전환;
	출처:아미고 / 퀵고
직교체
	5000
	26428
	ENSG00000115947
	ENSMUSG00000026761
	O43929
	O88708
NM_001190879; NM_001190881; NM_001190882; NM_002552; NM_181741;
	NM_181742; NM_001374270; NM_001374272
	NM_001177313; NM_011958; NM_001355296
NP_001177808; NP_001177810; NP_001177811; NP_002543; NP_859525;
	NP_859526; NP_001361199; NP_001361201
	NP_001170784; NP_036088; NP_001342225
	위키다타
인간 보기/편집	마우스 보기/편집

원산지 인식 복합체 4는 인간에서 ORC4(ORC4L) 유전자에 의해 인코딩되는 단백질이다.^[5]^[6]^[7]

함수

원산지 인식 콤플렉스(ORC)는 진핵 세포에서 DNA 복제를 시작하는 데 필수적인 6개 서브유닛 단백질 콤플렉스다.효모에 대한 연구는 ORC가 복제의 기원에 특별히 결합하고 있으며 Cdc6와 Mcm 단백질과 같은 추가 개시 인자의 조립을 위한 플랫폼 역할을 한다는 것을 입증했다.이 유전자에 의해 인코딩된 단백질은 ORC 복합체의 서브 유닛이다.ORC2L, -3L, -5L로 핵심단지를 형성하는 것으로 나타났다.동일한 단백질을 인코딩하는 세 가지 다른 분할된 대본 변형들이 보고되었다.^[7]

상호작용

ORC4는 다음과 상호작용하는 것으로 나타났다.

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000115947 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000026761 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A (Nov 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247–51. doi:10.1074/jbc.272.45.28247. PMID 9353276.
^ Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22-->q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 81 (1): 89–90. doi:10.1159/000014997. PMID 9691185. S2CID 46878915.
^ ^a ^b "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)".
^ ^a ^b ^c ^d ^e ^f ^g ^h Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
^ ^a ^b ^c Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.
^ ^a ^b Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.
^ Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi:10.1016/s0896-6273(00)80752-7. PMID 10402192. S2CID 781511.
^ Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". The Journal of Biological Chemistry. 273 (42): 27137–45. doi:10.1074/jbc.273.42.27137. PMID 9765232.

추가 읽기

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972.
Springer J, Kneissl M, Pütter V, Grummt F (Aug 1999). "Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex". Chromosoma. 108 (4): 243–9. doi:10.1007/s004120050374. PMID 10460412. S2CID 8689588.
Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". The EMBO Journal. 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMC 1171637. PMID 10523313.
Thome KC, Dhar SK, Quintana DG, Delmolino L, Shahsafaei A, Dutta A (Nov 2000). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". The Journal of Biological Chemistry. 275 (45): 35233–41. doi:10.1074/jbc.M005765200. PMID 10954718.
Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.
Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.
Okuno Y, McNairn AJ, den Elzen N, Pines J, Gilbert DM (Aug 2001). "Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle". The EMBO Journal. 20 (15): 4263–77. doi:10.1093/emboj/20.15.4263. PMC 149150. PMID 11483529.
Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612.
Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J (Jul 2004). "Self-assembling protein microarrays". Science. 305 (5680): 86–90. doi:10.1126/science.1097639. PMID 15232106. S2CID 20936301.
Sibani S, Price GB, Zannis-Hadjopoulos M (May 2005). "Ku80 binds to human replication origins prior to the assembly of the ORC complex". Biochemistry. 44 (21): 7885–96. doi:10.1021/bi047327n. PMID 15910003.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

인간 염색체 2의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000115947 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000026761 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9353276-5] Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A (Nov 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247–51. doi:10.1074/jbc.272.45.28247. PMID 9353276.

[pmid9691185-6] Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22-->q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 81 (1): 89–90. doi:10.1159/000014997. PMID 9691185. S2CID 46878915.

[entrez-7] "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)".

[pmid12614612-8] ^ ^a ^b ^c ^d ^e ^f ^g ^h Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.

[pmid11395502-9] Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.

[pmid11323433-10] Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.

[pmid10402192-11] Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi:10.1016/s0896-6273(00)80752-7. PMID 10402192. S2CID 781511.

[pmid9765232-12] Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". The Journal of Biological Chemistry. 273 (42): 27137–45. doi:10.1074/jbc.273.42.27137. PMID 9765232.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

Search

ORC4

네임스페이스

더

목차

함수

상호작용

참조

추가 읽기