MCM3

MCM3
식별자
별칭	MCM3, HCC5, P1-P1.h, RLFB, 미니크로모솜 유지보수 복합 구성 요소 3
외부 ID	OMIM: 602693 MGI: 101845 HomoloGene: 1791 GeneCard: MCM3
유전자 위치(인간)
쳇.	6번 염색체(인간)
끝	52,284,881 bp
유전자 위치(마우스)
쳇.	1번 염색체(쥐)
끝	20,890,536 bp
RNA 표현 패턴
	표현된 상단
	태아; ; 강리온의 명성; ; 맹장; ; 직장의; ; 림프절; ; 폐골.; ; 골수; ; 2차 난모세포; ; 아킬레스건; ; 흉선;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	DNA 결합; 뉴클레오티드 결합; GO:0008026 헬리카아제 활동; GO:0001948 단백질 결합; 수산화효소 활동; ATP 바인딩; DNA 복제 원본 바인딩; 단일 가닥의 DNA 결합;
셀룰러 컴포넌트	세포질; 센트로놈의; 막으로 막다; 핵종의; 세포질 과핵 지역; 알파 DNA 중합효소:주효소 복합체; MCM 복합체; 핵의; 뉴클레오루스; 세포내 막으로 둘러싸인 오르가넬;
생물학적 과정	G1상; DNA 복제; DNA 복제 시작; 세포 순환; 유사 세포 주기의 G1/S 전환; 파손에 의한 복제를 통한 이중 패시브 파손 수리; 핵 세포 주기 DNA 복제와 관련된 복제 전 복합체 조립; DNA 복제와 관련된 DNA 가닥의 신장; 유사 DNA 복제 시작;
	출처:아미고 / 퀵고
직교체
	4172
	17215
	ENSG00000112118
	ENSMUSG00000041859
	P25205; Q7Z6P5
	P25206
	NM_002388; NM_001270472
	NM_008563
NP_001257401; NP_002379; NP_001353298; NP_001353299; NP_001353300;
	NP_001353301; NP_001353302; NP_001353303; NP_001353304
	NP_032589
	위키다타
인간 보기/편집	마우스 보기/편집

DNA 복제 라이선스 인자 MCM3는 인간에게 MCM3 유전자에 의해 암호화된 단백질이다.^[5]

함수

이 유전자에 의해 암호화된 단백질은 진핵 게놈 복제의 시작에 관여하는 보존도가 높은 MCM(미니크로모솜 유지 단백질) 중 하나이다.MCM 단백질에 의해 형성된 육각 단백질 복합체는 복제 전 복합체(pre-RC)의 핵심 성분으로 복제 포크 형성과 다른 DNA 복제 관련 단백질의 모집에 관여할 수 있다.이 단백질은 MCM2-7로 구성된 단백질 복합체의 서브 유닛이다.MCM5/CDC46과 직접 상호작용하는 것으로 나타났다.이 단백질은 또한 상호작용을 하므로 염색질 관련 아세틸전달효소인 MCM3AP에 의해 아세틸화된다.이 단백질의 아세틸화는 DNA 복제와 세포 주기 진행의 시작을 억제한다.^[6]

상호작용

MCM3는 다음과 상호 작용하는 것으로 나타났다.

참고 항목

미니 염색체 유지 관리

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000112118 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000041859 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Thömmes P, Fett R, Schray B, Burkhart R, Barnes M, Kennedy C, Brown NC, Knippers R (April 1992). "Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein". Nucleic Acids Res. 20 (5): 1069–74. doi:10.1093/nar/20.5.1069. PMC 312092. PMID 1549468.
^ "Entrez Gene: MCM3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)".
^ ^a ^b ^c ^d ^e ^f ^g Kneissl M, Pütter V, Szalay AA, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
^ ^a ^b Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. 274 (36): 25927–32. doi:10.1074/jbc.274.36.25927. PMID 10464337.
^ Méndez J, Stillman B (November 2000). "Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis". Mol. Cell. Biol. 20 (22): 8602–12. doi:10.1128/mcb.20.22.8602-8612.2000. PMC 102165. PMID 11046155.
^ Takei Y, Assenberg M, Tsujimoto G, Laskey R (November 2002). "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3". J. Biol. Chem. 277 (45): 43121–5. doi:10.1074/jbc.C200442200. PMID 12226073.
^ Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N (April 2000). "A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication". Blood. 95 (7): 2321–8. doi:10.1182/blood.V95.7.2321. PMID 10733502.
^ Takei Y, Tsujimoto G (August 1998). "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization". J. Biol. Chem. 273 (35): 22177–80. doi:10.1074/jbc.273.35.22177. PMID 9712829.
^ DaFonseca CJ, Shu F, Zhang JJ (March 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. Bibcode:2001PNAS...98.3034D. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027.
^ Fujita M, Kiyono T, Hayashi Y, Ishibashi M (April 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751.
^ Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. 277 (12): 10354–61. doi:10.1074/jbc.M111398200. PMID 11779870.

추가 읽기

Musahl C, Schulte D, Burkhart R, Knippers R (1995). "A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins". Eur. J. Biochem. 230 (3): 1096–101. doi:10.1111/j.1432-1033.1995.tb20660.x. PMID 7601140.
Schulte D, Burkhart R, Musahl C, Hu B, Schlatterer C, Hameister H, Knippers R (1995). "Expression, phosphorylation and nuclear localization of the human P1 protein, a homologue of the yeast Mcm 3 replication protein". J. Cell Sci. 108 (4): 1381–9. doi:10.1242/jcs.108.4.1381. PMID 7615659.
Starborg M, Brundell E, Gell K, Larsson C, White I, Daneholt B, Höög C (1995). "A murine replication protein accumulates temporarily in the heterochromatic regions of nuclei prior to initiation of DNA replication". J. Cell Sci. 108 (3): 927–34. doi:10.1242/jcs.108.3.927. PMID 7622621.
Burkhart R, Schulte D, Hu D, Musahl C, Göhring F, Knippers R (1995). "Interactions of human nuclear proteins P1Mcm3 and P1Cdc46". Eur. J. Biochem. 228 (2): 431–8. doi:10.1111/j.1432-1033.1995.tb20281.x. PMID 7705359.
Kubota Y, Mimura S, Nishimoto S, Takisawa H, Nojima H (1995). "Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor". Cell. 81 (4): 601–9. doi:10.1016/0092-8674(95)90081-0. PMID 7758114. S2CID 18797719.
Madine MA, Khoo CY, Mills AD, Laskey RA (1995). "MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells". Nature. 375 (6530): 421–4. Bibcode:1995Natur.375..421M. doi:10.1038/375421a0. PMID 7760938. S2CID 4316044.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hu B, Burkhart R, Schulte D, Musahl C, Knippers R (1994). "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins". Nucleic Acids Res. 21 (23): 5289–93. doi:10.1093/nar/21.23.5289-a. PMC 310560. PMID 8265339.
Schulte D, Richter A, Burkhart R, Musahl C, Knippers R (1996). "Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins". Eur. J. Biochem. 235 (1–2): 144–51. doi:10.1111/j.1432-1033.1996.00144.x. PMID 8631321.
Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650.
Sato N, Arai K, Masai H (1997). "Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7". EMBO J. 16 (14): 4340–51. doi:10.1093/emboj/16.14.4340. PMC 1170060. PMID 9250678.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Takei Y, Tsujimoto G (1998). "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization". J. Biol. Chem. 273 (35): 22177–80. doi:10.1074/jbc.273.35.22177. PMID 9712829.
Zhang JJ, Zhao Y, Chait BT, Lathem WW, Ritzi M, Knippers R, Darnell JE (1999). "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation". EMBO J. 17 (23): 6963–71. doi:10.1093/emboj/17.23.6963. PMC 1171044. PMID 9843502.
Yankulov K, Todorov I, Romanowski P, Licatalosi D, Cilli K, McCracken S, Laskey R, Bentley DL (1999). "MCM Proteins Are Associated with RNA Polymerase II Holoenzyme". Mol. Cell. Biol. 19 (9): 6154–63. doi:10.1128/MCB.19.9.6154. PMC 84545. PMID 10454562.
Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. 274 (36): 25927–32. doi:10.1074/jbc.274.36.25927. PMID 10464337.
Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N (2000). "A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication". Blood. 95 (7): 2321–8. doi:10.1182/blood.V95.7.2321. PMID 10733502.
Hofmann Y, Becker J, Wright F, Avner ED, Mrug M, Guay-Woodford LM, Somlo S, Zerres K, Germino GG, Onuchic LF (2000). "Genomic structure of the gene for the human P1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease". Eur. J. Hum. Genet. 8 (3): 163–6. doi:10.1038/sj.ejhg.5200426. PMID 10780780.
Abe E, Kuwahara K, Yoshida M, Suzuki M, Terasaki H, Matsuo Y, Takahashi EI, Sakaguchi N (2000). "Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication". Gene. 255 (2): 219–27. doi:10.1016/S0378-1119(00)00336-X. PMID 11024281.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000112118 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000041859 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1549468-5] Thömmes P, Fett R, Schray B, Burkhart R, Barnes M, Kennedy C, Brown NC, Knippers R (April 1992). "Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein". Nucleic Acids Res. 20 (5): 1069–74. doi:10.1093/nar/20.5.1069. PMC 312092. PMID 1549468.

[entrez-6] "Entrez Gene: MCM3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)".

[pmid12614612-7] ^ ^a ^b ^c ^d ^e ^f ^g Kneissl M, Pütter V, Szalay AA, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.

[pmid10464337-8] Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. 274 (36): 25927–32. doi:10.1074/jbc.274.36.25927. PMID 10464337.

[pmid11046155-9] Méndez J, Stillman B (November 2000). "Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis". Mol. Cell. Biol. 20 (22): 8602–12. doi:10.1128/mcb.20.22.8602-8612.2000. PMC 102165. PMID 11046155.

[pmid12226073-10] Takei Y, Assenberg M, Tsujimoto G, Laskey R (November 2002). "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3". J. Biol. Chem. 277 (45): 43121–5. doi:10.1074/jbc.C200442200. PMID 12226073.

[pmid10733502-11] Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N (April 2000). "A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication". Blood. 95 (7): 2321–8. doi:10.1182/blood.V95.7.2321. PMID 10733502.

[pmid9712829-12] Takei Y, Tsujimoto G (August 1998). "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization". J. Biol. Chem. 273 (35): 22177–80. doi:10.1074/jbc.273.35.22177. PMID 9712829.

[pmid11248027-13] DaFonseca CJ, Shu F, Zhang JJ (March 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. Bibcode:2001PNAS...98.3034D. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027.

[pmid9099751-14] Fujita M, Kiyono T, Hayashi Y, Ishibashi M (April 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751.

[pmid11779870-15] Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. 277 (12): 10354–61. doi:10.1074/jbc.M111398200. PMID 11779870.

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Search

MCM3

네임스페이스

더

목차

함수

상호작용

참고 항목

참조

추가 읽기