HMOX1
HMOX1
HMOX1(heme oxase 1 유전자)은 heme oxicase 1(EC 1.14.99.3) 효소를 암호화하는 인간 유전자다.헤메 산소효소(약칭 HMOX 또는 HO)는 헤메 카타볼리즘의 첫 단계를 매개하며, 헤메를 갈라 빌리버딘을 형성한다.
HMOX 유전자는 염기쌍 34,101,636부터 염기쌍 34,114,748까지 12.3 위치의 22번 염색체의 긴 (q) 암에 위치한다.
관련조건
헤메 산소효소
헤메 카타볼리즘의 필수 효소인 헤메 산소효소는 빌리버딘, 일산화탄소, 철철 등을 형성하기 위해 헤메를 분쇄한다.[5]빌리버딘은 이후 빌리버딘 환원효소에 의해 빌리루빈으로 전환된다.헤메 산소효소 활성은 기질 헤메와 다양한 비헤메 물질에 의해 유도된다.헤메 산소효소는 유도성 헤메 산소효소-1과 구성성 헤메 산소효소-2로 발생한다.HMOX1과 HMOX2는 헤메 산소효소군에 속한다.[6]
참고 항목
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000100292 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000005413 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lehninger's Principles of Biochemistry, 5th Edition. New York: W.H. Freeman and Company. 2008. pp. 876. ISBN 978-0-7167-7108-1.
- ^ "Entrez Gene: HMOX1 heme oxygenase (decycling) 1".
추가 읽기
- Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S (1999). "Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency". J Clin Invest. 103 (1): 129–35. doi:10.1172/JCI4165. PMC 407858. PMID 9884342.
- Zhang Z, Song Y, Zhang Z, Li D, Zhu H, Liang R, Gu Y, Pang Y, Qi J, Wu H, Wang J (2016). "Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice". J Cereb Blood Flow Metab. 37 (1): 25–38. doi:10.1177/0271678X16655814. PMC 5363754. PMID 27317654.
- Wang J, Doré S (2007). "Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage". Brain. 130 (6): 1643–52. doi:10.1093/brain/awm095. PMC 2291147. PMID 17525142.
- Soares MP, Brouard S, Smith RN, Bach FH (2002). "Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs". Immunol. Rev. 184: 275–85. doi:10.1034/j.1600-065x.2001.1840124.x. PMID 12086318.
- Morse D, Choi AM (2002). "Heme oxygenase-1: the "emerging molecule" has arrived". Am. J. Respir. Cell Mol. Biol. 27 (1): 8–16. doi:10.1165/ajrcmb.27.1.4862. PMID 12091240.
- Buelow R, Tullius SG, Volk HD (2002). "Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide". Am. J. Transplant. 1 (4): 313–5. doi:10.1034/j.1600-6143.2001.10404.x. PMID 12099373.
- Ishikawa K (2003). "Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders". Curr. Pharm. Des. 9 (30): 2489–97. doi:10.2174/1381612033453767. PMID 14529548.
- Exner M, Minar E, Wagner O, Schillinger M (2005). "The role of heme oxygenase-1 promoter polymorphisms in human disease". Free Radic. Biol. Med. 37 (8): 1097–104. doi:10.1016/j.freeradbiomed.2004.07.008. PMID 15451051.
- Ozono R (2006). "New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway". Current Pharmaceutical Biotechnology. 7 (2): 87–93. doi:10.2174/138920106776597630. PMID 16724942.
- Tracz MJ, Alam J, Nath KA (2007). "Physiology and pathophysiology of heme: implications for kidney disease". J. Am. Soc. Nephrol. 18 (2): 414–20. doi:10.1681/ASN.2006080894. PMID 17229906.
- Chang CF, Cho S, Wang J (2014). "(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways". Annals of Clinical and Translational Neurology. 1 (4): 258–271. doi:10.1002/acn3.54. PMC 3984761. PMID 24741667.
- Hill-Kapturczak N, Agarwal A (2007). "Haem oxygenase-1--a culprit in vascular and renal damage?". Nephrol. Dial. Transplant. 22 (6): 1495–9. doi:10.1093/ndt/gfm093. PMID 17389623.
외부 링크
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