HMOX2

HMOX2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2Q32, 2QPP, 2RGZ, 4WMH
식별자
에일리어스	HMOX2, HO-2, 헴산소화효소2
외부 ID	OMIM : 141251 MGI : 109373 HomoloGene : 1611 GenCard : HMOX2
유전자 위치(인간)
크르.	16번 염색체(인간)
끝.	4,510,347 bp
유전자 위치(마우스)
크르.	16번 염색체(쥐)
끝.	4,584,606 bp
RNA발현패턴
	상단 표시 위치:
	전전두피질; ; 좌심실; ; 상전두회; ; 브로드만 9구역; ; 핵액컴벤스; ; 위체; ; 창호; ; 뇌량; ; 미산핵; ; 흑색 실체;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	산화환원효소활성; GO:0001948 단백질 결합; 금속 이온 결합; 헴산소화효소(감경화)활성; 헴 결합;
셀룰러 컴포넌트	세포막내소기관; 소포체막; 막; 소포체; 혈장막; 특이 과립막;
생물학적 과정	저산소증에 대한 반응; 세포철 이온 항상성; 헴 산화; 산화 스트레스에 대한 반응; 헴 이화 과정; 호중구 탈과립; 철이온 항상성;
	출처:아미고 / QuickGO
맞춤법
	3163
	15369
	ENSG00000277424; ENSG00000103415
	ENSMUSG00000004070
	P30519
	O70252
NM_001127204; NM_001127205; NM_001127206; NM_001286267; NM_001286268;
	NM_001286269; NM_001286270; NM_001286271; NM_002134
	NM_001136066; NM_010443; NM_001357050; NM_001378999
NP_001120676; NP_001120677; NP_001120678; NP_001273196; NP_001273197;
	NP_001273198; NP_001273199; NP_001273200; NP_002125
	NP_001129538; NP_034573; NP_001343979; NP_001365928
	위키데이터
인간 보기/편집	마우스 표시/편집

헴산소효소2는 인체에서 HMOX2 유전자에 ^[5]^[6]의해 암호화되는 효소이다.

기능.

헴 이화효소의 필수효소인 헴산소화효소는 헴을 분해하여 빌리베르딘을 형성하고, 빌리베르딘 환원효소에 의해 빌리루빈으로 변환되며, 일산화탄소는 추정신경전달물질이다.헴산소효소 활성은 그 기질 헴 및 다양한 비헴 물질에 의해 유도된다.헴산소화효소는 유도성 헴산소화효소-1과 구성 헴산소화효소-2의 2가지 이소자임으로 발생한다.HMOX1 및 HMOX2(이 효소)는 ^[6]헴산소화효소군에 속한다.

레퍼런스

^ ^a ^b ^c ENSG00000103415 GRCh38: 앙상블 릴리즈 89: ENSG00000277424, ENSG00000103415 - Ensembl, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000004070 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McCoubrey WK, Ewing JF, Maines MD (Jun 1992). "Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal". Arch Biochem Biophys. 295 (1): 13–20. doi:10.1016/0003-9861(92)90481-B. PMID 1575508.
^ ^a ^b "Entrez Gene: HMOX2 heme oxygenase (decycling) 2".

추가 정보

Bianchetti CM, Yi L, Ragsdale SW, Phillips GN (2007). "Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2". J Biol Chem. 282 (52): 37624–31. doi:10.1074/jbc.M707396200. PMC 2896506. PMID 17965015.
Wang J, Zhuang H, Doré S (2006). "Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage". Neurobiol. Dis. 22 (3): 473–6. doi:10.1016/j.nbd.2005.12.009. PMID 16459095. S2CID 43195015.
Wang J, Doré S (2008). "Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage". Neuroscience. 155 (4): 1133–41. doi:10.1016/j.neuroscience.2008.07.004. PMC 4696610. PMID 18674596.
Barañano DE, Snyder SH (2001). "Neural roles for heme oxygenase: Contrasts to nitric oxide synthase". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 10996–1002. Bibcode:2001PNAS...9810996B. doi:10.1073/pnas.191351298. PMC 58673. PMID 11572959.
Doré S (2002). "Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease". Free Radic. Biol. Med. 32 (12): 1276–82. doi:10.1016/S0891-5849(02)00805-5. PMID 12057765.
Kemp PJ (2005). "Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction". Biochem. Biophys. Res. Commun. 338 (1): 648–52. doi:10.1016/j.bbrc.2005.08.110. PMID 16137652.
Ishikawa K, Takeuchi N, Takahashi S, Matera KM, Sato M, Shibahara S, Rousseau DL, Ikeda-Saito M, Yoshida T (1995). "Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2". J. Biol. Chem. 270 (11): 6345–50. doi:10.1074/jbc.270.11.6345. PMID 7890772.
Kutty RK, Kutty G, Rodriguez IR, Chader GJ, Wiggert B (1994). "Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3". Genomics. 20 (3): 513–6. doi:10.1006/geno.1994.1213. PMID 8034330.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Takahashi K, Hara E, Suzuki H, Sasano H, Shibahara S (1996). "Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors". J. Neurochem. 67 (2): 482–9. doi:10.1046/j.1471-4159.1996.67020482.x. PMID 8764571. S2CID 12552519.
Saito-Ohara F, Ikeuchi T, Matsumoto M, Kurata S (1997). "Assignment of the mouse heme oxygenase genes: heme oxygenase-1 (Hmox1) to chromosome 10 band C1 and heme oxygenase-2 (Hmox2) to chromosome 16 band B1". Cytogenet. Cell Genet. 77 (3–4): 180–1. doi:10.1159/000134570. PMID 9284910.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yoshiki N, Kubota T, Aso T (2000). "Expression and localization of heme oxygenase in human placental villi". Biochem. Biophys. Res. Commun. 276 (3): 1136–42. doi:10.1006/bbrc.2000.3551. PMID 11027601.
Hanselmann C, Mauch C, Werner S (2001). "Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?". Biochem. J. 353 (Pt 3): 459–66. doi:10.1042/0264-6021:3530459. PMC 1221590. PMID 11171041.
Appleton SD, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH, Lash GE (2003). "Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells". Am. J. Physiol. Heart Circ. Physiol. 284 (3): H853–8. doi:10.1152/ajpheart.00655.2002. PMID 12578814.
Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419. S2CID 22016092.
Zenclussen AC, Lim E, Knoeller S, Knackstedt M, Hertwig K, Hagen E, Klapp BF, Arck PC (2004). "Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies". Am. J. Reprod. Immunol. 50 (1): 66–76. doi:10.1034/j.1600-0897.2003.00047.x. PMID 14506930. S2CID 35763984.
Boehning D, Moon C, Sharma S, Hurt KJ, Hester LD, Ronnett GV, Shugar D, Snyder SH (2003). "Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2". Neuron. 40 (1): 129–37. doi:10.1016/S0896-6273(03)00596-8. PMID 14527438. S2CID 11562548.
Appleton SD, Lash GE, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH (2004). "Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells". Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (6): R1453–60. doi:10.1152/ajpregu.00234.2003. PMID 14615405.

인간 염색체 16번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] ENSG00000103415 GRCh38: 앙상블 릴리즈 89: ENSG00000277424, ENSG00000103415 - Ensembl, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000004070 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1575508-5] McCoubrey WK, Ewing JF, Maines MD (Jun 1992). "Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal". Arch Biochem Biophys. 295 (1): 13–20. doi:10.1016/0003-9861(92)90481-B. PMID 1575508.

[entrez-6] "Entrez Gene: HMOX2 heme oxygenase (decycling) 2".

[1]

[2]

[3]

[4]

[5]

[6]

Search

HMOX2

네임스페이스

더

기능.

레퍼런스

추가 정보