Egl 9 homological 2 는 인간에게 EGLN2 유전자 에 의해 암호화된 단백질 이다.[5] ELGN2는 알파-케토글루타레이트 의존성 히드록실라아제 로서, 비 헴 철분 함유 단백질의 슈퍼 계열이다.
저산소증유도인자 (HIF)는 산소기전증 에 관여하는 전사복합체다. 정상 산소 레벨에서 HIF의 알파 서브유닛은 프롤릴 히드록실화 에 의한 열화를 목표로 한다. 이 유전자는 이 변환 후의 수정을 담당하는 효소를 암호로 한다. 동일한 단백질을 인코딩하는 여러 가지 대안으로 분할된 변형들이 확인되었다.[5]
참조 추가 읽기 Semenza GL (2001). "HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus" . Cell . 107 (1): 1–3. doi :10.1016/S0092-8674(01)00518-9 PMID 11595178 . S2CID 14922615 . Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Jaakkola P, Mole DR, Tian YM, et al. (2001). "Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation". Science . 292 (5516): 468–72. Bibcode :2001Sci...292..468J . doi :10.1126/science.1059796 . PMID 11292861 . S2CID 20914281 . Ivan M, Kondo K, Yang H, et al. (2001). "HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing". Science . 292 (5516): 464–8. Bibcode :2001Sci...292..464I . doi :10.1126/science.1059817 . PMID 11292862 . S2CID 33725562 . Taylor MS (2001). "Characterization and comparative analysis of the EGLN gene family". Gene . 275 (1): 125–32. doi :10.1016/S0378-1119(01)00633-3 . PMID 11574160 . Epstein AC, Gleadle JM, McNeill LA, et al. (2001). "C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation" . Cell . 107 (1): 43–54. doi :10.1016/S0092-8674(01)00507-4 PMID 11595184 . S2CID 18372306 . Bruick RK, McKnight SL (2001). "A conserved family of prolyl-4-hydroxylases that modify HIF". Science . 294 (5545): 1337–40. Bibcode :2001Sci...294.1337B . doi :10.1126/science.1066373 . PMID 11598268 . S2CID 9695199 . Seth P, Krop I, Porter D, Polyak K (2002). "Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)" . Oncogene . 21 (5): 836–43. doi :10.1038/sj.onc.1205113 PMID 11850811 . Min JH, Yang H, Ivan M, et al. (2002). "Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling". Science . 296 (5574): 1886–9. Bibcode :2002Sci...296.1886M . doi :10.1126/science.1073440 . PMID 12004076 . S2CID 19641938 . McNeill LA, Hewitson KS, Gleadle JM, et al. (2002). "The use of dioxygen by HIF prolyl hydroxylase (PHD1)". Bioorg. Med. Chem. Lett . 12 (12): 1547–50. doi :10.1016/S0960-894X(02)00219-6 . PMID 12039559 . Oehme F, Ellinghaus P, Kolkhof P, et al. (2002). "Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors". Biochem. Biophys. Res. Commun . 296 (2): 343–9. doi :10.1016/S0006-291X(02)00862-8 . PMID 12163023 . Ivan M, Haberberger T, Gervasi DC, et al. (2002). "Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor" . Proc. Natl. Acad. Sci. U.S.A . 99 (21): 13459–64. Bibcode :2002PNAS...9913459I . doi :10.1073/pnas.192342099 PMC 129695 PMID 12351678 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Metzen E, Berchner-Pfannschmidt U, Stengel P, et al. (2003). "Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing" . J. Cell Sci . 116 (Pt 7): 1319–26. doi :10.1242/jcs.00318 PMID 12615973 . Cioffi CL, Liu XQ, Kosinski PA, et al. (2003). "Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells". Biochem. Biophys. Res. Commun . 303 (3): 947–53. doi :10.1016/S0006-291X(03)00453-4 . PMID 12670503 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Aprelikova O, Chandramouli GV, Wood M, et al. (2004). "Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors" . J. Cell. Biochem . 92 (3): 491–501. doi :10.1002/jcb.20067 . PMID 15156561 . S2CID 24455956 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 .
