알파-(1,3)-푸코실전달효소 는 인간에서 FUT9 유전자 에 의해 인코딩되는 효소 다.[5] [6] [7]
FUT9는 루이스 항원의 생합성에서 마지막 단계를 촉진할 수 있는 몇 가지 알파-3-푸코실전달물질 중 하나로, 전구 다당체에 후코스를 첨가한다. FUT9는 인간 발생기에 메센치마에서 진행 중인 장기 싹에서 발현되는 LeX 올리고당(CD15)을 합성한다. [OMIM에 의해 제공][7]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000172461 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000055373 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kaneko M, Kudo T, Iwasaki H, Ikehara Y, Nishihara S, Nakagawa S, Sasaki K, Shiina T, Inoko H, Saitou N, Narimatsu H (Jul 1999). "Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX" . FEBS Lett . 452 (3): 237–42. doi :10.1016/S0014-5793(99)00640-7 PMID 10386598 . S2CID 21861521 . ^ Kaneko M, Kudo T, Iwasaki H, Shiina T, Inoko H, Kozaki T, Saitou N, Narimatsu H (Jan 2000). "Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization". Cytogenet Cell Genet . 86 (3–4): 329–30. doi :10.1159/000015329 . PMID 10575236 . S2CID 85080516 . ^ a b "Entrez Gene: FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)" . 추가 읽기 Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Nishihara S, Iwasaki H, Kaneko M, et al. (2000). "Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue" . FEBS Lett . 462 (3): 289–94. doi :10.1016/S0014-5793(99)01549-5 PMID 10622713 . S2CID 37842289 . Cailleau-Thomas A, Coullin P, Candelier JJ, et al. (2000). "FUT4 and FUT9 genes are expressed early in human embryogenesis" . Glycobiology . 10 (8): 789–802. doi :10.1093/glycob/10.8.789 PMID 10929005 . Nakayama F, Nishihara S, Iwasaki H, et al. (2001). "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV" . J. Biol. Chem . 276 (19): 16100–6. doi :10.1074/jbc.M007272200 PMID 11278338 . Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism" . J. Biol. Chem . 277 (5): 3168–75. doi :10.1074/jbc.M107927200 PMID 11698403 . Toivonen S, Nishihara S, Narimatsu H, et al. (2003). "Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile" . Glycobiology . 12 (6): 361–8. doi :10.1093/glycob/12.6.361 PMID 12107078 . Li H, Kong Y, Yan B (2003). "[Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao . 34 (6): 775–9. PMID 12417923 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Nishihara S, Iwasaki H, Nakajima K, et al. (2004). "Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain" . Glycobiology . 13 (6): 445–55. doi :10.1093/glycob/cwg048 PMID 12626397 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 PMID 14574404 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Bogoevska V, Horst A, Klampe B, et al. (2006). "CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues" . Glycobiology . 16 (3): 197–209. doi :10.1093/glycob/cwj057 PMID 16282604 .
