FUT6

FUT6
식별자
별칭	FUT6, FCT3A, FT1A, Fuc-TVI, FucT-VI, Fucosyl transferase 6
외부 ID	OMIM: 136836 호몰로진: 34780 GeneCard: FUT6
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	5,839,722 bp
RNA 표현 패턴
	표현된 상단
	신장 피질; ; 기관지; ; 척수; ; 체쿰;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	전이효소 활동; 알파(1->3)-후코실전달효소 활성; 3-갈락토실-N-아세틸글루코사미드 4-알파-L-푸코실전달효소 활성; 글리코실전달효소 활성; 후코실전달효소 활동;
셀룰러 컴포넌트	막의 적분 성분; 골지 시스테나 막; 골지 기구; 세포외 외성체; 막으로 막다; 골지막;
생물학적 과정	단백질 당화; L-푸코오스 카타볼라 공정; 푸코실화; 세라마이드 대사 과정;
	출처:아미고 / 퀵고
직교체
	2528
	n/a
	ENSG00000156413
	n/a
	P51993
	n/a
NM_000150; NM_001040701; NM_001369502; NM_001369504; NM_001369505;
	NM_001381955; NM_001381956; NM_001381957; NM_001381958; NM_001381959
	n/a
NP_000141; NP_001035791; NP_001356431; NP_001356433; NP_001356434;
	NP_001368884; NP_001368885; NP_001368886; NP_001368887; NP_001368888
	n/a
	위키다타
인간 보기/편집

알파-(1,3)-푸코실전달효소는 인간에서 FUT6 유전자에 의해 인코딩되는 효소다.^[3]^[4]^[5]

알파-1,3-푸코실전달효소는 동질성이 높은 많은 글리코실전달효소를 구성한다.이 계열의 효소는 구별되는 올리고당 수용체에 알파-L-퓨코스를 이전하는 능력, N-에틸말랄리미드 억제 민감성, 양이온 요구사항 및 조직별 표현 패턴에 기초하여 미엘로이드, 플라즈마, 루이스라고 불리는 3가지 주요 활동 패턴으로 구성된다.알파-1,3-푸코실 전이의 다른 범주는 태아 발달 중에 순차적으로 표현된다.[OMIM에 의해 제공]^[5]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000156413 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Koszdin KL, Bowen BR (Oct 1992). "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand". Biochem Biophys Res Commun. 187 (1): 152–7. doi:10.1016/S0006-291X(05)81472-X. PMID 1520296.
^ McCurley RS, Recinos A III, Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW (Jul 1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21". Genomics. 26 (1): 142–6. doi:10.1016/0888-7543(95)80094-3. PMID 7782074.
^ ^a ^b "Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)".

추가 읽기

Weston BW, Smith PL, Kelly RJ, Lowe JB (1992). "Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes". J. Biol. Chem. 267 (34): 24575–84. doi:10.1016/S0021-9258(18)35803-4. PMID 1339443.
Cameron HS, Szczepaniak D, Weston BW (1995). "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms". J. Biol. Chem. 270 (34): 20112–22. doi:10.1074/jbc.270.34.20112. PMID 7650030.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Mollicone R, Reguigne I, Fletcher A, et al. (1994). "Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6)". J. Biol. Chem. 269 (17): 12662–71. doi:10.1016/S0021-9258(18)99927-8. PMID 8175676.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Borsig L, Imbach T, Höchli M, Berger EG (2000). "alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles". Glycobiology. 9 (11): 1273–80. doi:10.1093/glycob/9.11.1273. PMID 10536043.
Schnyder-Candrian S, Borsig L, Moser R, Berger EG (2000). "Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8369–74. Bibcode:2000PNAS...97.8369S. doi:10.1073/pnas.97.15.8369. PMC 26954. PMID 10900002.
Kamińska J, Musielak M, Nowicka A, et al. (2001). "Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase". Biochimie. 83 (8): 739–42. doi:10.1016/S0300-9084(01)01306-2. PMID 11530205.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kanoh A, Ota M, Narimatsu H, Irimura T (2003). "Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion". Biochem. Biophys. Res. Commun. 303 (3): 896–901. doi:10.1016/S0006-291X(03)00420-0. PMID 12670495.
Martinez-Duncker I, Michalski JC, Bauvy C, et al. (2004). "Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis". Glycobiology. 14 (1): 13–25. doi:10.1093/glycob/cwh006. PMID 14514715.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Higai K, Miyazaki N, Azuma Y, Matsumoto K (2007). "Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene". FEBS Lett. 580 (26): 6069–75. doi:10.1016/j.febslet.2006.09.073. PMID 17054948. S2CID 9731951.

19번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000156413 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1520296-3] Koszdin KL, Bowen BR (Oct 1992). "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand". Biochem Biophys Res Commun. 187 (1): 152–7. doi:10.1016/S0006-291X(05)81472-X. PMID 1520296.

[pmid7782074-4] McCurley RS, Recinos A III, Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW (Jul 1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21". Genomics. 26 (1): 142–6. doi:10.1016/0888-7543(95)80094-3. PMID 7782074.

[entrez-5] "Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)".

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